Levosimendan Increases Survival in a D-Galactosamine and Lipopolysaccharide Rat Model [PDF]
Biomedicines, 2022 Levosimendan, a calcium sensitizer, has an organ protective profile through the inhibition of inflammatory mediators and cytokines in critical conditions, such as heart failure, ischemia-reperfusion injury, and sepsis. The survival effect of levosimendan
Tatsuma Sakaguchi +7 more
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Crosstalk of TNF-α, IFN-γ, NF-kB, STAT1 and redox signaling in lipopolysaccharide/d-galactosamine/dimethylsulfoxide-induced fulminant hepatic failure in mice [PDF]
Saudi Pharmaceutical Journal, 2023 Purpose: The clinical study of fulminant hepatic failure is challenging due to its high mortality and relative rarity, necessitating reliance on pre-clinical models to gain insight into its pathophysiology and develop potential therapies.
Abdulrazaq Alanazi +10 more
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D-Galactosamine Causes Liver Injury Synergistically with Lipopolysaccharide but not Zymosan in Chicks [PDF]
The Journal of Poultry Science, 2023 The pathogen-associated molecular patterns (PAMPs) lipopolysaccharide (LPS) and zymosan, derived from gram-negative bacteria and fungi, respectively, activate the innate immune system and cause injury to multiple organs, including the liver and intestine,
Maki Takahashi +6 more
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Evaluation of Brown Micro-Algae Synergies With Low Dose -Radiation Against Chronic Hepatitis Induced by D-Galactosamine in Rats [PDF]
Dose-Response, 2023 Introduction Hepatic inflammation is considered key driver of hepatic tissue impairment.We aimed to explore the interaction of Halamphora coffeaeformis ( Amph .) with low dose ionizing γ radiation ( γ R) exposure against D-galactosamine (D-GaIN)-induced ...
Salma Elsaman +3 more
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Carfilzomib Mitigates Lipopolysaccharide/D-Galactosamine/Dimethylsulfoxide-Induced Acute Liver Failure in Mice [PDF]
Biomedicines, 2023 Acute liver failure (ALF) is a disease accompanied by severe liver inflammation. No effective therapy is available yet apart from liver transplantation; therefore, developing novel treatments for ALF is urgently required.
Dhafer Y. Alhareth +9 more
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Postępy MikrobiologiiBacteria use a variety of mechanisms in order to successfully survive in hosts. To support proliferation sophisticated means of maintenance in host especially metabolism of carbon and nitrogen is needed. One metabolic mechanism is the metabolism of amino
Petruńko Leon, Gmiter Dawid
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Co-administration of lipopolysaccharide and d-galactosamine induces genotoxicity in mouse liver [PDF]
Scientific Reports, 2021 The acute liver injury (ALI) and hepatic fibrosis caused by the co-treatment of lipopolysaccharide (LPS)/d-galactosamine (D-GalN) have been extensively studied. However, whether LPS/D-GalN are genotoxic has been left unknown.
Wenjing Dong, Erqun Song, Yang Song
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Lysimachiae Herba Inhibits Inflammatory Reactions and Improves Lipopolysaccharide/D-Galactosamine-Induced Hepatic Injury [PDF]
Antioxidants, 2021 This study aimed to determine the anti-inflammatory and hepatoprotective effects of Lysimachiae Herba ethanolic extract (LHE) in lipopolysaccharide (LPS)-stimulated macrophages and in a LPS/D-galactosamine (GalN)-induced acute hepatitis mouse model. Then,
Yun Hee Jeong +3 more
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Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis.
Journal of Lipid Research, 1983 D-(+)-galactosamine (GalN) induces severe reversible hepatocellular injury in the rat accompanied by lecithin: cholesterol acyltransferase (LCAT) deficiency, defective chylomicron (CM) catabolism, and accumulation of abnormal plasma lipoproteins (Lps ...
D D Black, P Tso, S Weidman, S M Sabesin
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The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D-Galactosamine-Sensitized Mouse Model of Lethal Shock [PDF]
BMC MicrobiologyToxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, is one of the most potent superantigens involved in causing life-threatening TSS and contributes to the onset of some autoimmune diseases.
Fatemeh Rahimi-Jamnani +6 more
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