Results 41 to 50 of about 24,218 (173)

Protective effect of wild ginseng cambial meristematic cells on d-galactosamine-induced hepatotoxicity in rats

Journal of Ginseng Research, 2015
Background: Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium.
Seok-Joo Kim, Hyo-Sun Choi, Hong-Ik Cho, Young-Woo Jin, Eun-Kyong Lee, Jeung Youb Ahn, Sun-Mee Lee   +6 more
doaj   +1 more source

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality

Frontiers in Immunology, 2017
Multi-organ failure in response to uncontrolled microbial infection is characterized by low blood pressure accompanied by a systemic over-inflammation state, caused by massive pro-inflammatory cytokines release and liver damage.
Jessica Perego, Clarisse Bourbon, Lionel Chasson, Caroline Laprie, Lionel Spinelli, Voahirana Camosseto, Evelina Gatti, Evelina Gatti, Evelina Gatti, Philippe Pierre, Philippe Pierre, Philippe Pierre   +11 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Establishment of a new acute-on-chronic liver failure model

Acta Pharmaceutica Sinica B, 2017
To establish an animal model of acute-on-chronic liver failure (ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum (PS) for 11 weeks.
Fangfang Li, Luyang Miao, Hua Sun, Yuyang Zhang, Xiuqi Bao, Dan Zhang   +5 more
doaj   +1 more source

Mechanisms of Resistance, Insights From Case Reports, and Future Prospects in Mycobacteriophage Therapy

Journal of the Royal Society of New Zealand, Volume 56, Issue 4, August 2026.
Evolution of drug‐resistant mycobacterial infections warrants renewed efforts in identifying more efficient preventive and control strategies as well as alternative treatment options. Interest in phage therapy is regaining significant traction, especially in cases of failed conventional therapy.
Buhari Yusuf, Abdul Malik, Md Shah Alam, Lijie Li, Haftay Abraha Tadesse, Aweke Mulu Belachew, Cuiting Fang, Xirong Tian, Htin Lin Aung, Shuai Wang, Tianyu Zhang   +10 more
wiley   +1 more source

Conditional knockout of membrane‐type I matrix metalloproteinase in smooth muscle cells of adult mice alleviates atherosclerosis without affecting basic cardiovascular function

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Expression of smooth muscle cell‐specific MMP14 increases with atherosclerosis progression in humans. Inducible conditional knockout of SMC‐MMP14 in adult mice does not affect cardiac or vascular function. Inducible conditional knockout of SMC‐MMP14 in adult Ldlr−/− mice decreases atherosclerosis progression, increases plaque stability and accelerates ...
Suha Jarad, Hong‐Mei Gu, Daniel Huang, Peter Amadi, Govind Gill, Floor Spaans, Aakar Chatha, Ala Yousef, Murilo E. Graton, Raj Patel, John M. Seubert, Ying Wang, Gordon Francis, Xiao‐Dan Xia, Sandra T. Davidge, Da‐Wei Zhang   +15 more
wiley   +1 more source

Synthesis, Inhibitory Effects on Nitric Oxide and Structure-Activity Relationships of a Glycosphingolipid from the Marine Sponge Aplysinella rhax and Its Analogues

Molecules, 2011
The novel glycosphingolipid, b-D-GalNAcp(1®4)[a-D-Fucp(1®3)]-b-D-GlcNAcp(1®)Cer (A), isolated from the marine sponge Aplysinella rhax has a unique structure, with D-fucose and N-acetyl-D-galactosamine moieties attached to a reducing-end N-acetyl-D ...
Naohiro Ohshima, Ai Hasegawa, Frank Schweizer, Tadahiro Takeda, Fumiyuki Kiuchi, Noriyasu Hada, Yuzo Fujita   +6 more
doaj   +1 more source

Mass Spectrometry and NMR Spectroscopy‐Based Structural Characterization of Polysaccharide From Gastrodia elata Blume

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Structural characterization of complex carbohydrates remains challenging. This study employed methylation, acid hydrolysis, 1‐phenyl‐3‐methyl‐5‐pyrazolone (PMP) derivatization, and ultra‐high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) to determine monosaccharides, glycosidic linkages, and sequence of ...
Hui Yan, Cheng‐Xi Feng, Zhe Wang, Jun‐Qiao Wang, Shao‐Ping Nie   +4 more
wiley   +1 more source

The Model of D-Galactosamine-Induced Injury of Rat Hepatocytes in Primary Culture

Acta Medica, 2006
D-galactosamine (GalN) is a highly selective hepatotoxin that causes liver damage similar to human viral hepatitis via depletion of uridine nucleotides, which subsequently diminishes synthesis of RNA and proteins. Model of galactosamine hepatotoxicity is
Otto Kučera, Halka Lotková, Roman Kanďár, Renata Héžová, Vladimíra Mužáková, Zuzana Červinková   +5 more
doaj   +1 more source