Results 61 to 70 of about 24,218 (173)

Experimental phytocorrection of acute D-galactosamine hepatitis

Yakut Medical Journal, 2018
The aim of our research was in defining hepatoprotective properties of new complex plant supplement on a rat model of D-galactosamine hepatitis. Intensity of the main pathogenetic syndromes was evaluated by biochemical tests, lipid peroxidation grade and morphological research.
E.A. Ubeeva, Ya.G. Razuvayeva, D.N. Olennikov, I.P. Ubeeva, S.M. Nicolaev, L.D. Dymsheeva   +5 more
openaire   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Apolipoprotein C-III0 lacks carbohydrate residues: use of mass spectrometry to study apolipoprotein structure.

Journal of Lipid Research, 1989
Apolipoprotein C-III (apo C-III) is a 79 amino acid glycoprotein. The sugar moiety of apoC-III is attached to amino acid residue 74 and is thought to consist of 1 mole of galactose, 1 mole of N-acetyl-galactosamine, and either 0, 1, or 2 moles of sialic ...
Y Ito, J L Breslow, B T Chait
doaj   +1 more source

D-Galactosamine Hepatotoxicity II. Mechanism of Fatty Liver Production

Experimental Biology and Medicine, 1971
SummaryThe administration of a single dose of D-galactosamine (1.5 g/kg) results in hepatocellular necrosis and fatty liver in the rat. Hepatic triglyceride accumulation is not altered by administration of adenine, ATP, uridine, uridine nucleotides, or uridine di-phosphoglucose.Protein synthesis in vivo is impaired as early as 4 hr after administration
R S, Koff, J J, Fitts, S M, Sabesin, H J, Zimmerman   +3 more
openaire   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Role of the GalNAc-galectin pathway in the healing of premature rupture of membranes

Molecular Medicine
Background Premature rupture of the membranes (PROM) is a key cause of preterm birth and represents a major cause of neonatal mortality and morbidity.
Jia-Le Chen, Lou Liu, Xin-Rui Peng, Yan Wang, Xiang Xiang, Yu Chen, De-Xiang Xu, Dao-Zhen Chen   +7 more
doaj   +1 more source

Xenotransplantation of Human Umbilical Cord Blood Mononuclear Cells to Rats with D-Galactosamine-Induced Hepatitis

Cell Transplantation, 2008
Cord blood is an attractive cell source in regenerative medicine and represents an alternative to bone marrow. The aim of this study was to investigate whether human umbilical cord blood mononuclear (HUCBM) cells might be valuable in hepatic regenerative
Ana I. Álvarez-Mercado, María J. Sáez-Lara, María V. García-Mediavilla, Sonia Sánchez-Campos, Francisco Abadía, María Cabello-Donayre, Ángel Gil, Javier Gonzalez-Gallego, Luis Fontana   +8 more
doaj   +1 more source

Anti-apoptotic and Hepatoprotective Effects of Gomisin A on Fulminant Hepatic Failure Induced by D-Galactosamine and Lipopolysaccharide in Mice

Journal of Pharmacological Sciences, 2008
This study examined the effects of gomisin A, a lignan compound from Schisandra fructus, on D-galactosamine (GalN) and lipopolysaccharide (LPS)-induced hepatic apoptosis and liver failure. Mice were given an intraperitoneal injection of GalN (700 mg/kg) /
Sung-Hwa Kim, Yeong Shik Kim, Sam Sik Kang, KiHwan Bae, Tran Manh Hung, Sun-Mee Lee   +5 more
doaj   +1 more source

Pharmacokinetics of Glycyrrhizin in Rats with D-Galactosamine-Induced Hepatic Disease.

Biological and Pharmaceutical Bulletin, 1996
The pharmacokinetic behavior of glycyrrhizin (GZ) was examined in D-galactosamine-intoxicated (GAL) rats. When GZ was administered intravenously, the apparent volume of distribution (Vdss) and the total body clearance (CLtotal) were more significantly decreased in GAL rats than those in normal rats.
WANG, Zhao, OKAMOTO, Mariko, KUROSAKI, Yuji, NAKAYAMA, Taiji, KIMURA, Toshikiro   +4 more
openaire   +3 more sources

Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides

Beilstein Journal of Organic Chemistry, 2019
Here, we present an exploratory study on the fluorous-assisted synthesis of chondroitin sulfate (CS) oligosaccharides. Following this approach, a CS tetrasaccharide was prepared.
Teresa Mena-Barragán, José L. de Paz, Pedro M. Nieto   +2 more
doaj   +1 more source