Results 31 to 40 of about 24,218 (173)

Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice

Frontiers in Pharmacology, 2018
Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Ling, is known to exhibit anti-inflammatory, anti-viral, and anti-tumor activities. However, the effects of costunolide on liver injury are poorly understood. The current study aimed
Jingxin Mao, Man Yi, Rui Wang, Yuanshe Huang, Min Chen   +4 more
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats

Drug Design, Development and Therapy, 2022
Seerat Mehdi,1 Fiaz-ud-Din Ahmad,1 Arslan Hussain Lodhi,1 Umair Khurshid,2 Ahmed Awais Khalid,1 Sheikh Safeena Sidiq,1 Liaqat Hussain,3 Mirza Shaharyar Baig1 1Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur ...
Mehdi S, Ahmad FUD, Lodhi AH, Khurshid U, Khalid AA, Sidiq SS, Hussain L, Baig MS   +7 more
doaj  

ANTIOXIDATIVE EFFECT OF EPIGALLOCATECHIN GALLATE AGAINST D-GALACTOSAMINE-INDUCED INJURY IN PRIMARY CULTURE OF RAT HEPATOCYTES

Acta Medica, 2014
Literature data support that green tea and its major component epigallocatechin gallate (EGCG) have powerful antioxidant effects. Contrary, hepatotoxicity can be induced by high-dose EGCG. The timing of exposure to green tea in relation to administration
Alena Moravcová, Zuzana Červinková, Otto Kučera, Vojtěch Mezera, Halka Lotková   +4 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

The influence of carbohydrates in the interaction of Paracoccidioides brasiliensis with CCL-6 cells in vitro

Revista da Sociedade Brasileira de Medicina Tropical, 2012
INTRODUCTION: Little is known about the early events in the interaction between Paracoccidioides brasiliensis and its host. To understand the effect of carbohydrates in the interaction between the fungus and epithelial cell in culture, we analyzed the ...
Francisco Laurindo da Silva, Raphael Sanzio Pimenta, Juliana Fonseca Moreira da Silva, Déborah Aparecida Negrão Corrêa, Ary Corrêa Junior   +4 more
doaj   +1 more source

Effect of bergenin on D-galactosamine-induced acute liver injury in rats

Zhongguo gonggong weisheng, 2022
ObjectiveTo study protective effect and mechanism of bergenin on D-galactosamine (D-GalN)-induced acute liver injury in rats.MethodsTotally 60 Sprague-Dawley (SD) rats were randomly assigned into 6 groups (10 in each group): a control and a model group ...
Jie XU, Ya GAO, Yan-ping JI
doaj   +1 more source

Degradable versus inert microplastics: Effects on soil organic carbon persistence via microbial drivers in an agroecosystem

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Microplastics (MPs) are widespread in terrestrial ecosystems, raising global concerns that they may disrupt soil organic carbon (SOC) cycling and undermine agroecosystem contributions to climate mitigation.
Meng‐Ying Li, Wei Wang, Yue Ma, Jia‐Yao Yang, Shu‐Tong Liu, Xiao‐Bin Xiong, Tingting Zhao, Yuanze Sun, Saddam Saqib, Muhammd Ashraf, Matthias C. Rillig, You‐Cai Xiong   +11 more
wiley   +1 more source

Hepatoprotective Effects of Sedum sarmentosum on d-Galactosamine/ Lipopolysaccharide–Induced Murine Fulminant Hepatic Failure

Journal of Pharmacological Sciences, 2010
The hepatoprotective effects of sarmentosin-containing extracts of Sedum sarmentosum (SS) in d-galactosamine ( d-GalN) / lipopolysaccharide (LPS)–induced fulminant hepatic failure mouse model.
Li-Hua Lian, Xuejun Jin, Yan-Ling Wu, Xing Fu Cai, Jung Joon Lee, Ji-Xing Nan   +5 more
doaj   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source