Results 21 to 30 of about 24,218 (173)

Hepatoprotective effect of pentoxifylline against D-galactosamine-induced hepatotoxicity in rats

Annals of Hepatology, 2009
The present study was conducted to investigate effect of pentoxifylline (PTX) on acute liver injury caused by galactosamine (D-Gal) in rats and the underlying mechanism involved in this setting.
Ashraf Taye, Mohamed A. El-Moselhy, Magdy K.A. Hassan, Hanaa M. Ibrahim, Aliaa F. Mohammed   +4 more
doaj   +1 more source

Investigating a novel hepatoprotective substance from ume extract (heated Japanese apricot juice concentrate). Part 1: Finding an active substance using a liver injury rat model

NFS Journal, 2022
Background: The Japanese apricot (Prunus mume Sieb. et Zucc.) is popularly known as ume in Japan, and the heated concentrate of ume juice, called ume extract, is commonly consumed as food.
Katsuya Hiraishi, Fumie Jimma, Hiroyuki Soma, Tomohiro Kagawa, Ippei Yamaoka   +4 more
doaj   +1 more source

Modification of the Hepatotoxicity of D-Galactosamine in the Rat by Cycloheximide

Experimental Biology and Medicine, 1976
The effect of cycloheximide (1.5 mg/kg), a potent inhibitor of protein biosynthesis, on D-galastosamine (375 mg/kg)-induced hepatic necrosis and hepatic triglyceride accumulation was studied in rats. Serum transaminase levels, 24 hr after D-galactosamine administration, were significantly reduced in animals treated simultaneously or 4 hr before D ...
R S, Koff, L J, Connelly
openaire   +2 more sources

Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases

Angewandte Chemie, EarlyView.
We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson, Madouc D. Bergers, David N. Bolam, Ana S. Luis, Alan Cartmell, Zachary Armstrong   +5 more
wiley   +2 more sources

Succinate dehydrogenase inhibitor dimethyl malonate alleviates LPS/-galactosamine-induced acute hepatic damage in mice

Innate Immunity, 2019
In addition to its energy-supplying function, increasing evidence suggests that mitochondria also play crucial roles in the regulation of inflammation.
Yongqiang Yang, Ruyue Shao, Li Tang, Longjiang Li, Min Zhu, Jiayi Huang, Yi Shen, Li Zhang   +7 more
doaj   +1 more source

The effect of cholinesterase inhibition on liver dysfunction in experimental acute liver failure

Egyptian Journal of Critical Care Medicine, 2013
Introduction: Acute liver failure (ALF), like sepsis, is associated with an overwhelming activation of the immune response in which hepatic and circulating inflammatory cytokines play a pivotal role.
Rasha S. Bondok, Mona A. Ahmed, Nevine Bahaa E. Soliman, Mona H. El-Shokry, Rania M. Ali, Hala F. Fahmy, Mohamed S. Eldin   +6 more
doaj   +1 more source

Impaired Hepatocyte Regeneration in Acute Severe Hepatic Injury Enhances Effective Repopulation by Transplanted Hepatocytes

Cell Transplantation, 2009
Efficient repopulation by transplanted hepatocytes in the severely injured liver is essential for their clinical application in the treatment of acute hepatic failure.
Chun-Hsien Yu, Hui-Ling Chen, Ya-Hui Chen, Ming-Fu Chang, Chin-Sung Chien, Mei-Hwei Chang M.D.   +5 more
doaj   +1 more source

Naltrexone Protects Against Lipopolysaccharide/D-Galactosamine–Induced Hepatitis in Mice

Journal of Pharmacological Sciences, 2008
Naltrexone, an opioid receptor antagonist, has been claimed to have anti-inflammatory and immunomodulatory effects both in vitro and in vivo.
Chien-Chuan Wang, Pao-Yun Cheng, Yie-Jen Peng, Edwin SC Wu, Hsiao-Ping Wei, Mao-Hsiung Yen   +5 more
doaj   +1 more source

Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure

European Journal of Medical Research, 2011
Secondary activation of the endothelin system is thought to be involved in toxic liver injury. This study tested the hypothesis that dual endothelin-converting enzyme / neutral endopeptidase blockade might be able to attenuate acute toxic liver injury ...
Hocher B, Heiden S, von Websky K, Rahnenführer J, Kalk P, Pfab T   +5 more
doaj   +1 more source

Expression pattern of glycoconjugates in the Bidderian and ovarian follicles of the Brazilian toad Bufo ictericus analyzed by lectin histochemistry

Brazilian Journal of Biology
The Bidder's organ and ovary of the Brazilian toad Bufo ictericus were studied by light microscopy, using hematoxylin-eosin (HE) and periodic acid Schiff (PAS) staining.
C. F. Farias, R. A. Azevedo, L. Brito-Gitirana   +2 more
doaj   +1 more source