Results 11 to 20 of about 24,218 (173)

Luzindole attenuates LPS/-galactosamine-induced acute hepatitis in mice [PDF]

Innate Immunity, 2020
Melatonin is a well-documented hormone that plays central roles in the regulation of sleep–wake cycles. There is cumulative evidence to suggest that melatonin is also a pleiotropic regulator of inflammation, and luzindole has been widely used as a ...
Yisheng Luo, Yongqiang Yang, Yi Shen, Longjiang Li, Jiayi Huang, Li Tang, Li Zhang   +6 more
doaj   +2 more sources

Evaluating the best time to intervene acute liver failure in rat models induced by d-galactosamine [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To describe an animal model for acute liver failure by intraperitoneal d-galactosamine injections in rats and to define when is the best time to intervene through King's College and Clichy´s criteria evaluation.
Lígia Patrícia de Carvalho Batista Éboli, Alcides Augusto Salzedas Netto, Ramiro Antero de Azevedo, Valéria Pereira Lanzoni, Tatiana Sugayama de Paula, Alberto Goldenberg, Adriano Miziara Gonzalez   +6 more
doaj   +1 more source

Possible Association Between DHEA and PKCε in Hepatic Encephalopathy Amelioration: A Pilot Study

Frontiers in Veterinary Science, 2021
Objective: Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by liver failure and by an impaired neurotransmission and neurological function caused by hyperammonemia (HA).
Alessandro Di Cerbo, Luca Roncati, Carlotta Marini, Gianluca Carnevale, Manuela Zavatti, Rossella Avallone, Lorenzo Corsi, Lorenzo Corsi   +7 more
doaj   +1 more source

Prevention of the hepatotoxic effects of D‐galactosamine by D‐galactose [PDF]

FEBS Letters, 1973
Galactosamine hepatitis [l] is accompanied by decreased incorporation of amino acid into protein [2,3] and of uridine into RNA in the liver [2]. Recently the inhibition of induction of rat liver tyrosine amino transferase by D-galactosamine has been reported [4].
Mészáros, K., Antoni, F., Hrabák, A., Szikla, Ch., Garzó, T., Tompa, Anna, Lapis, K.   +6 more
openaire   +2 more sources

Hepatoprotective activity of a new polyherbal formulation against paracetamol and D-galactosamine induced hepatic toxicity

Journal of Pharmacy and Bioallied Sciences, 2015
Objective: The present study was envisaged to evaluate the protective effect of polyherbal formulation, DRDC/AY/8060, developed by Dabur India Ltd., against paracetamol and D-galactosamine induced hepatic toxicities in Wistar rats. Materials and Methods:
Mohammad Ahmed Khan, Arun Gupta, Satyendra Kumar, Sayeed Ahmad, J.L.N. Sastry   +4 more
doaj   +1 more source

Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1

Frontiers in Pharmacology, 2020
High mobility group box-1 (HMGB1) plays an important role in various liver injuries. In the case of acute liver injury, it leads to aseptic inflammation and other reactions, and also regulates specific cell death responses in chronic liver injury.
Peng Fang, Jiajun Liang, Xuejiao Jiang, Xian Fang, Mengli Wu, Xiaoyi Wei, Wenlong Yang, Weixin Hou, Qiuyun Zhang   +8 more
doaj   +1 more source

HPLC-PDA-MS/MS Characterization of Bioactive Secondary Metabolites from Turraea fischeri Bark Extract and Its Antioxidant and Hepatoprotective Activities In Vivo

Molecules, 2017
Turraea fischeri is an East African traditional herb, which is widely used in traditional medicine. In this study, we profiled the secondary metabolites in the methanol extract of T.
Mansour Sobeh, Mona F. Mahmoud, Omar M. Sabry, Rasha Adel, Malak Dmirieh, Assem M. El-Shazly, Michael Wink   +6 more
doaj   +1 more source

Phosphorylation of eIF2α mitigates endoplasmic reticulum stress and hepatocyte necroptosis in acute liver injury

Annals of Hepatology, 2020
Introduction and objectives: Necroptosis and endoplasmic reticulum (ER) stress has been implicated in acute and chronic liver injury. Activated eukaryotic initiation factor 2 alpha (eIF2α) attenuates protein synthesis and relieves the load of protein ...
Ren-Dong Tian, Yi-Qun Chen, Yi-Huai He, Yong-Jing Tang, Gui-Mei Chen, Fang-Wan Yang, Ying Li, Wen-Ge Huang, Huan Chen, Xia Liu, Shi-De Lin   +10 more
doaj   +1 more source

Effect of Lochein on liver metabolism under acute intoxication caused by the paracetamol and D-galactosamine

Бюллетень сибирской медицины, 2006
Influence of original hepatoprotector lochein in comparison with influence of reference drug silimarin on metabolism of liver under acute intoxication caused in rats by the paracetamol or D -galactosamine was investigated in the given study.
A. N. Sokolovskaya
doaj   +1 more source

Synthesis and in vitro cytotoxicity of acetylated 3-fluoro, 4-fluoro and 3,4-difluoro analogs of D-glucosamine and D-galactosamine

Beilstein Journal of Organic Chemistry, 2016
Background: Derivatives of D-glucosamine and D-galactosamine represent an important family of the cell surface glycan components and their fluorinated analogs found use as metabolic inhibitors of complex glycan biosynthesis, or as probes for the study of
Štěpán Horník, Lucie Červenková Šťastná, Petra Cuřínová, Jan Sýkora, Kateřina Káňová, Roman Hrstka, Ivana Císařová, Martin Dračínský, Jindřich Karban   +8 more
doaj   +1 more source