Results 181 to 190 of about 41,097 (233)
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Colchicine prevents d-galactosamine-induced hepatitis
Journal of Hepatology, 1989The hepatoprotective effect of colchicine in a model of liver intoxication with galactosamine (GalN), 375 mg/kg, i.p., was studied in rats. At 0.5, 1, 3, 6, 18 and 24 h after GalN intoxication the following markers of liver damage were measured: serum activity of alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase, hepatic ...
M, Mourelle, M A, Meza
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Biochimica et Biophysica Acta (BBA) - Enzymology, 1973
Abstract The activity of uridine diphosphoglucose (UDPG) dehydrogenase (UDPG: NAD+ oxidoreductase, EC 1.1.1.22) from rat liver is inhibited markedly in vitro by galactosamine 1-phosphate and UDPgalactosamine. The Ki value is calculated to be 6.2·10−3 M for galactosamine-1-phosphate. The type of inhibition is non-competitive.
Christian Bauer, Werner Reutter
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Abstract The activity of uridine diphosphoglucose (UDPG) dehydrogenase (UDPG: NAD+ oxidoreductase, EC 1.1.1.22) from rat liver is inhibited markedly in vitro by galactosamine 1-phosphate and UDPgalactosamine. The Ki value is calculated to be 6.2·10−3 M for galactosamine-1-phosphate. The type of inhibition is non-competitive.
Christian Bauer, Werner Reutter
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Galactosamine Glycan of Chondrococcus columnaris
Science, 1966The marked viscosity of liquid cultures of the myxobacterium Chondrococcus columnaris is caused by production of an extracellular polysaccharide. The polysaccharide is a high-molecular-weight homopolymer of D-galactosamine in which the galactosamine subunits are connected by α -(1→4 ...
J L, Johnson, W S, Chilton
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Galactosamine: A precursor of glycogen glucosamine
Biochemical and Biophysical Research Communications, 1966Abstract Galactosamine-1-14C was found to be incorporated into rat liver glycogen as glucosamine following perfusion or intraportal injection. The glucosamine was shown to be glycosidically linked to glucose by isolation of a disaccharide containing glucose and glucosamine after β-amylase treatment of the glycogen.
F, Maley, J F, McGarrahan, R, DelGiacco
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Syntheses of α-d-galactosamine neoglycolipids
Carbohydrate Research, 2006Several N-acetyl-alpha-d-galactosamine neoglycolipids, as well as hydrophobized T and T(N) antigen analogues, were prepared for embedment onto liposomes. Three different lipidic structures were used for the anchoring, that is cholesterol, 1,3-bis(undecyloxy)propan-2-ol and 1,3-bis(3,7,11,15-tetramethylhexadecyloxy)propan-2-ol.
Nicolas, Laurent +2 more
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Cystamine modulation of galactosamine-induced hepatotoxicity
Toxicology and Applied Pharmacology, 1984The ability of cystamine treatment to protect against galactosamine-induced hepatic necrosis was investigated. Reduced hepatotoxicity was observed following galactosamine hydrochloride (400 mg/kg, ip) in male Sprague-Dawley rats that received cystamine dihydrochloride (300 mg/kg, po) 30 min prior to or 2, 4, 6, 8, or 12 hr after galactosamine.
J R, MacDonald +2 more
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Analytical Biochemistry, 1963
Abstract A method is presented for the rapid differentiation, on a micro scale, of glucosamine, galactosamine, glucosamine uronic acid, and galactosamine uronic acid by paper electrophoresis of their deamination products in borate buffer. A new spray reagent for the specific detection of the 2-amino-2-deoxy sugars is also described; this is based on ...
A R, WILLIAMSON, S, ZAMENHOF
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Abstract A method is presented for the rapid differentiation, on a micro scale, of glucosamine, galactosamine, glucosamine uronic acid, and galactosamine uronic acid by paper electrophoresis of their deamination products in borate buffer. A new spray reagent for the specific detection of the 2-amino-2-deoxy sugars is also described; this is based on ...
A R, WILLIAMSON, S, ZAMENHOF
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Copper protects against galactosamine-induced hepatitis
Journal of Hepatology, 1987Although copper is believed to be hepatotoxic in Wilson's disease and Indian Childhood Cirrhosis (ICC), the rat shows only minimal hepatic damage on copper-loading. To investigate the possibility that copper deposition may potentiate the effects of a superimposed hepatitis, D-galactosamine (GalN) was given to copper-loaded and control rats.
L, Barrow, A, Kantarjian, M S, Tanner
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Ultrastructural features in galactosamine-induced hepatitis
Experimental and Molecular Pathology, 1970Abstract Electron microscopic examinations of the livers of rats with the previously described galactosamine-induced hepatitis showed after 1 day extensive hypertrophy of the smooth endoplasmic reticulum, glycogen depletion, liposomes and larger fat droplets, mitochondrial irregularities, large cytoplasmic vacuoles containing serum proteins, and ...
A, Medline, F, Schaffner, H, Popper
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Biochemical Pharmacology, 1990
Livers of male albino NMRI mice were perfused in situ at a flow rate of 3 ml/min/g liver in a non-recirculation system. The organs remained intact for at least 3 hr as assessed by release of lactate dehydrogenase (LDH) into the perfusate and by constant O2 consumption.
J F, Wang, A, Wendel
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Livers of male albino NMRI mice were perfused in situ at a flow rate of 3 ml/min/g liver in a non-recirculation system. The organs remained intact for at least 3 hr as assessed by release of lactate dehydrogenase (LDH) into the perfusate and by constant O2 consumption.
J F, Wang, A, Wendel
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