Small, EarlyView.Saccharide‐appended cyclic dipeptides are designed and developed as building blocks for glycosidase‐responsive supramolecular hydrogels. Their aqueous self‐assembly enables β‐galactosidase‐triggered gel‐to‐sol and neuraminidase‐triggered sol‐to‐gel transition systems, highlighting their potential as glycosidase‐responsive soft materials for biomedical ...
Shintaro Sugiura +6 more
wiley +1 more source
The genome-scale sugar metabolic model from <i>Neurospora crassa</i> reveals lower gene redundancy than that of <i>Aspergillus niger</i>. [PDF]
Curr Res Microb SciLi J +5 more
europepmc +1 more source
Smart Molecules, EarlyView.A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song +6 more
wiley +1 more source
The C-type lectin AcCTL5 from <i>Apis cerana</i> mediates anti-<i>Nosema ceranae</i> defense via agglutination and hemolymph melanization. [PDF]
VirulenceLi D +8 more
europepmc +1 more source
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source
Integrative Transcriptomic and Metabolomic Analyses Provide Insights into the Regulatory Basis of <i>Streptomyces pactum</i> Act12-Associated Root Development in Wheat. [PDF]
Plants (Basel)Zhang J +6 more
europepmc +1 more source
Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, EarlyView.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Comparative Insights into Digestion and Gut Microbiota Modulation of Polysaccharides from Ginseng, Ganoderma lucidum, and Dendrobium officinale. [PDF]
FoodsPan X +7 more
europepmc +1 more source
Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An +7 more
wiley +1 more source
Zinc oxide nanoparticles mitigate insulin resistance in a D-galactose-induced C57BL/6 mouse model. [PDF]
Front Endocrinol (Lausanne)Ramasubbu K, V DR.
europepmc +1 more source