Results 211 to 220 of about 261,281 (306)

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Cryogenic Infrared Spectroscopy Unmasks Gas‐Phase Charge Migration in Mucin‐Type O‐Glycans

Small, EarlyView.
Protons in a sugar rush: O‐glycans are vital biomolecules, challenging to analyze due to isomeric forms. Using ion mobility spectrometry, cryogenic IR spectroscopy, and ab initio calculations, isomeric O‐glycan cores can be distinguished. At cryogenic temperatures, multiple deprotomers were identified, which interconvert at ambient conditions via rapid
Marc Safferthal, Gurpur Rakesh D. Prabhu, América Y. Torres‐Boy, Jerome Riedel, Leïla Bechtella, Wesley Pietsch, Gerard Meijer, Gert von Helden, Gaël M. Vos, Kevin Pagel   +9 more
wiley   +1 more source

Molecular basis of collagen galactosylation by GLT25D1. [PDF]

Nat Commun
Sun H, Zhang M, Shi Y, Zhang D, Hua Z, Yang P, Yang Y, Li J, Chen J, Wang C, Li P, Hu X, Ke Y, Zhang M, Liu X, Yu H.   +15 more
europepmc   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

VIEW, EarlyView.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta, Somayeh Fardindoost, Azadeh Abdi, Kaveh Yazdani, Longfei Yin, Syamak Farajikhah, Mina Hoorfar, Fariba Dehghani   +7 more
wiley   +1 more source

Balanced polyunsaturated fatty acids diet prevents the D-galactose-induced neuroinflammation and cognitive impairments. [PDF]

Neurosci Appl
Marniquet I, Dupont-Viratelle J, Crespo F, Séré A, Layé S, Delpech JC.   +5 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Dietary serine supplementation improves growth performance and intestinal immunity and modulates gut microbiota in chronic oxidative stress-induced weaned piglets. [PDF]

Anim Nutr
Chen H, Liu Y, Jin S, Wang C, He Y, Zhou H, Chen M, Feng Y, Wang W, Ma H, He X, Liu D, Li T, Yin Y, He L.   +14 more
europepmc   +1 more source

Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An, Chen‐Yu Xu, Meng‐Ya Shen, Xiao‐Tao Guo, Chun‐Chen Pan, Jing‐Wu Sun, Xiao‐Min Tang, Jia‐Qiang Sun   +7 more
wiley   +1 more source

Bioactive Polysaccharides from Blue Honeysuckle Berries: Structural Properties and Digestive Enzyme Inhibition Activities. [PDF]

Int J Mol Sci
Ding N, Sun J, Li J, Huo J, Zhang Y.
europepmc   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source