Results 181 to 190 of about 18,981 (340)

Circular RNA Telomerase Reverses Endothelial Senescence in Progeria

open access: yesAging Cell, EarlyView.
TERT circRNA outperforms linear TERT mRNA in reversing the hallmarks of senescence. TERT circRNA more efficiently restores endothelial function and shows superior capability in enhancing mitochondrial function. ABSTRACT Telomeres shorten with each cell division, acting as a chronometer of cell age. The enzyme telomerase, primarily active in stem cells,
Weifeng Qin   +6 more
wiley   +1 more source

Engineering the β-galactosidase from Aspergillus oryzae for making lactose-free and no-sugar-added yogurt

open access: yesJournal of Dairy Science
: Yogurt usually contains 5% to 7% sugar and 3% to 5% lactose. As β-galactosidases can hydrolyze lactose and improve sweetness, they have the potential to produce lactose-free (LF) and no-sugar-added (NSA) yogurt.
Miao Miao   +5 more
doaj  

Comparative Inductive Responses of Two β-Galactosidases of Neurospora

open access: bronze, 1967
W. K. Bates   +2 more
openalex   +1 more source

Deciphering the Contribution of Circular RNAs to Age‐Related Decline in Sertoli Cell Survivor

open access: yesAging Cell, EarlyView.
Sertoli cell survival is regulated by circAbcb9‐ceRNET. Physiologically, the circAbcb9 sponge activity toward miR‐214‐3p ensures the expression of SOX8 and NOTCH2 targets, both crucial in maintaining SC homeostasis. The aging process negatively affects FUS‐dependent backsplicing activity in Sertoli cells leading to circAbcb9 downregulation, and in turn,
Francesco Manfrevola   +11 more
wiley   +1 more source

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

open access: yesAging Cell, EarlyView.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud   +19 more
wiley   +1 more source

Diabetes Advances Cardiomyocyte Senescence Through Interfering Rnd3 Expression and Function

open access: yesAging Cell, EarlyView.
Diabetes‐induced upregulation of miR‐103a‐3p suppresses Rnd3 expression in cardiomyocytes, thereby promoting the senescence‐associated secretory phenotype (SASP) through activation of the STAT3 signaling pathway, mediated by UPS‐induced degradation of p‐STAT3.
Linxu Wu   +16 more
wiley   +1 more source

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