Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu +5 more
wiley +1 more source
Immobilized Enzymes for ABO-Independent Blood Cell Transfusions. [PDF]
Möller C +11 more
europepmc +1 more source
ABSTRACT Mitochondrial dysfunction and energy imbalance caused by chemotherapy are key contributors to skeletal muscle atrophy, which severely impacts the quality of life in cancer patients. Paclitaxel, a commonly used chemotherapeutic agent, is known to promote muscle wasting and cellular senescence, largely by impairing mitochondrial function.
Yu‐Fan Chuang +6 more
wiley +1 more source
Enzymatic galactosylation of phenolic compounds by permeabilized cells of Pantoea anthophila. [PDF]
Briceño JR +6 more
europepmc +1 more source
Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song +3 more
wiley +1 more source
Expression, Purification, and Functional Exploration of an α-Galactosidase from <i>Akkermansia muciniphila</i>. [PDF]
Zuo T +6 more
europepmc +1 more source
Produção da β-galactosidase em Saccharomyces cerevisiae floculante após transformação integrativa
António Velho +2 more
openalex +1 more source
Kinetic studies on exploring lactose hydrolysis potential of β galactosidase extracted from Lactobacillus plantarum HF571129 [PDF]
Selvarajan Ethiraj, V. Mohanasrinivasan
openalex +1 more source
LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source

