Results 211 to 220 of about 19,728 (332)

Mechanism elucidation of cell‐selective fluorescent probes

Smart Molecules, EarlyView.
This perspective outlines five mechanistic strategies—Protein‐oriented, carbohydrate‐oriented, lipid‐oriented, gating‐oriented, and metabolism‐oriented live‐cell distinctions—for achieving cell‐selective fluorescence in live‐cell imaging. By classifying probes based on their interactions with proteins, carbohydrates, lipids, transporters, or metabolic ...
Sourav Sarkar, Young‐Tae Chang
wiley   +1 more source

Heterologous Production, Purification and Characterization of Two Cold-Active β-d-Galactosidases with Transglycosylation Activity from the Psychrotolerant Arctic Bacterium Arthrobacter sp. S3* Isolated from Spitsbergen Island Soil. [PDF]

Int J Mol Sci
Wanarska M, Pawlak-Szukalska A, Rosińska A, Kozłowska-Tylingo K.   +3 more
europepmc   +1 more source

α-Galactosidase and Sucrose-Kinase Relationships in a Bi-functional AgaSK Enzyme Produced by the Human Gut Symbiont Ruminococcus gnavus E1

, 2020
Mickaël Lafond, Alexandra Tauzin, L. Brüel, Élisabeth Laville, Vincent Lombard, Jérémy Esque, Isabelle André, Nicolas Vidal, Frédérique Pompeo, Nathalie Quinson, Josette Perrier, Michel Fons, Gabrielle Potocki-Véronèse, Thierry Giardina   +13 more
openalex   +1 more source

β‐Galactosidase Based Molecular Imaging for Visualization of Cellular Senescence

iRADIOLOGY, EarlyView.
Jiani Huang, Peili Cen, Hong Zhang, Yan Zhong   +3 more
wiley   +1 more source

Fluorophore Modulates Intracellular Distribution of Enzyme‐Instructed Self‐Assembly of Short Peptides in Osteosarcoma Cells

Small Methods, EarlyView.
Fluorophores at the peptide C‐terminus reprogram EISA behavior in osteosarcoma cellsshifting ER vs mitochondrial targeting, altering assembly, and tuning cytotoxicity. Abstract Enzyme‐instructed self‐assembly (EISA) of peptides offers a versatile strategy for developing intracellular nanomedicines, yet the role of C‐terminus fluorophores in modulating ...
Yali Huang, Meihui Yi, Yuchen Qiao, Bing Xu   +3 more
wiley   +1 more source

Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects. [PDF]

Genes Dis
Jiang M, Xu Q, Wu Z.
europepmc   +1 more source

α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice [PDF]

, 2010
Koji Higuchi, Makoto Yoshimitsu, Xin Fan, Xiaoxin Guo, Vanessa I. Rasaiah, Jennifer Yen, Chuwa Tei, Toshihiro Takenaka, Jeffrey A. Medin   +8 more
openalex   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Advances in β-Galactosidase Research: A Systematic Review from Molecular Mechanisms to Enzyme Delivery Systems. [PDF]

Pharmaceutics
Király M, Barna ÁT, Kállai-Szabó N, Kiss BD, Antal I, Ludányi K.   +5 more
europepmc   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, EarlyView.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source