Results 191 to 200 of about 17,093 (242)

Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in parkinson's disease brain. [PDF]

Nat Commun
Hällqvist J, Toomey CE, Pinto R, Baldwin T, Doykov I, Wernick A, Al Shahrani M, Evans JR, Lachica J, Pope S, Heales S, Eaton S, Mills K, Gandhi S, Heywood WE.   +14 more
europepmc   +1 more source

Interplay between innate-like T-cells and microRNAs in cancer immunity. [PDF]

Discov Oncol
Yousefi MJ, Afshar Y, Amoozadehsamakoosh A, Naseri A, Soltani F, Yazdanpanah N, Saleki K, Rezaei N.   +7 more
europepmc   +1 more source

A divergent synthesis of α-galactosylceramide analogues

, 2012
Guillaume, Joren, Van Calenbergh, Serge
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An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells

Carbohydrate Research, 2019
Herein, an efficient synthesis of BODIPY-α-Galactosylceramide 3, which can be used to study the cellular uptake of the potent immunostimulatory parent compound α-Galactosylceramide, is reported. Key in our synthetic strategy is the six-step synthesis of the core BODIPY scaffold (64% yield overall) and its quantitative conversion to an N ...
Cheng, Janice M.H., Chee, Stephanie H., Dolen, Y., Verdoes, M., Timmer, M., Stocker, Bridget L.   +5 more
openaire   +4 more sources

Exogenous Galactosylceramide as Potential Treatment for CLN3 Disease

Annals of Neurology, 2019
ObjectiveCLN3 disease is the commonest of the neuronal ceroid lipofuscinoses, a group of pediatric neurodegenerative disorders. Functions of the CLN3 protein include antiapoptotic properties and facilitating anterograde transport of galactosylceramide from Golgi to lipid rafts.
Sally El‐Sitt, Jihane Soueid, Katia Maalouf, Nadine Makhoul, Jamal Al Ali, Joelle Makoukji, Bilal Asser, Daniel Daou, Hayat Harati, Rose‐Mary Boustany   +9 more
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Galactosylceramides in Human Plasma

American Journal of Clinical Pathology, 1973
The purpose of this investigation was to establish levels of cerebrosides in human plasma as a guide in investigating cerebroside levels in destructive and demyelinating central nervous system disorders. As an increase in plasma galactosylceramide may accompany myelin breakdown, this test may serve as a means of monitoring diseases such as multiple ...
H W, Wells, M, Jones
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Alpha-galactosylceramide-driven immunotherapy for allergy

Frontiers in Bioscience, 2008
We report here that the delivery of both alpha-galactosylceramide (alphaGalCer), a representative ligand for invariant natural killer T (iNKT) cells, and an antigenic polypeptide to marginal zone B cells induces the differentiation of regulatory cells in vivo, and suppresses the secondary antibody responses in mice.
Yasuyuki, Ishii, Risa, Nozawa, Yukiko, Takamoto-Matsui, Annabelle, Teng, Haruka, Katagiri-Matsumura, Hiroshi, Nishikawa, Hiroyuki, Fujita, Yuki, Tamura   +7 more
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Peptide-free Synthetic Nicotine Vaccine Candidates with α-Galactosylceramide as Adjuvant.

Molecular Pharmaceutics, 2019
Peptides are generally needed as T-helper epitopes in nicotine vaccines to induce effective antibody responses, but the highly polymorphic property of major histocompatibility complex (MHC) molecules may limit opportunities of B cell to receive CD4+ T ...
Xiang-Zhao Chen, Ru-yan Zhang, Xi-Feng Wang, Xu-Guang Yin, Jian Wang, Ya-Cong Wang, Xiulei Liu, Jing-jing Du, Zheng Liu, Jun-Gu Guo   +9 more
semanticscholar   +1 more source

Acyl structure regulates galactosylceramide's interfacial interactions

Biochemistry, 1993
Galactosylceramides (GalCer) with homogeneous acyl chains containing zero, one, or two cis double bonds have been synthesized and characterized at an argon-aqueous buffer interface using a Langmuir film balance. Both surface pressure and surface potential were measured as a function of molecular area at 24 degrees C. N-Lignoceroylgalactosylsphingosine (
S, Ali, J M, Smaby, R E, Brown
openaire   +2 more sources