Results 131 to 140 of about 4,713 (170)

Drastically Abnormal Gluco- and Galactosylceramide Composition Does Not Affect Ganglioside Metabolism in the Brain of Mice Deficient in Galactosylceramide Synthase

Neurochemical Research, 1999
Mice that are genetically deficient in UDP-galactose: ceramide galactosyltransferase are unable to synthesize galactosylceramide. Consequently, sulfatide, which can be synthesized only by sulfation of galactosylceramide, is also totally absent in affected mouse brain.
K, Suzuki, M T, Vanier, T, Coetzee, B, Popko   +3 more
openaire   +2 more sources

Acyl structure regulates galactosylceramide's interfacial interactions

Biochemistry, 1993
Galactosylceramides (GalCer) with homogeneous acyl chains containing zero, one, or two cis double bonds have been synthesized and characterized at an argon-aqueous buffer interface using a Langmuir film balance. Both surface pressure and surface potential were measured as a function of molecular area at 24 degrees C. N-Lignoceroylgalactosylsphingosine (
S, Ali, J M, Smaby, R E, Brown
openaire   +2 more sources

Use of Mixed Dispersion of Fluorescent Galactosylceramide and Sodium Dodecylsulfate for Assaying Galactosylceramide-β-Galactosidase and Diagnosing Krabbe Disease

Enzyme, 2017
A fluorescent derivative of galactosylceramide [NBD-GalCer: 12-N-methyl-N- (7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminodecanoyl galactosylceramide] was dispersed in sodium dodecylsulfate and used to determine the activity of galactosylceramide-β-galactosidase.
R, Salvayre, S, Gatt
openaire   +2 more sources

Effect of Galactosylceramide on the Dynamics of Cholesterol-Rich Lipid Membranes

The Journal of Physical Chemistry B, 2011
We use atom-scale molecular dynamics simulations to clarify the role of glycosphingolipids in the dynamics of cholesterol-rich lipid rafts. To this end, we consider lipid membranes that contain varying amounts of galactosylceramide (GalCer), sphingomyelin, cholesterol, and phosphatidylcholine.
Hall Anette, Vattulainen Ilpo, Rog Tomasz, Vattulainen Ilpo   +3 more
openaire   +4 more sources

Glucosylceramide and Galactosylceramide Synthase

2006
Most mammalian glycosphingolipid formation begins with the synthesis of cerebrosides, glucosylceramide and galactosylceramide. The synthases catalyzing the formations of glucosylceramide (GlcCer) and galactosylceramide (GalCer) have been characterized at the gene and protein levels.
openaire   +1 more source

Clinical Trials with α-Galactosylceramide (KRN7000) in Advanced Cancer

2011
For over a century, research has sought ways to boost the immune system of cancer patients in order to eradicate tumors that arose after escaping presumptive immunosurveillance. With increasing knowledge of the immune system, immunotherapeutic strategies to break tolerance to the tumor evolved from largely nonspecific to more specific and increasingly ...
Schneiders, Famke L., Scheper, Rik J., Bontkes, Hetty J., von Blomberg, B. Mary E., Eertwegh, Alfons J.M., de Gruijl, Tanja D., Van Der Vliet, Hans J.   +6 more
openaire   +5 more sources

Synthesis of a glucosylated α-S-galactosylceramide as potential immunostimulant

Carbohydrate Research, 2017
Synthesis of a glucosylated α-S-galactosylceramide (1), a potential immunostimulant, was achieved starting from D-galactose. Both O- and S-glycosidic linkages were constructed in highly stereoselective way, and the synthetic strategy could be extended to the synthesis of other α-S-GalCer analogues.
Lei, Zhang, Cian Mc, Carthy, Xiangming, Zhu   +2 more
openaire   +2 more sources

Unique sensitivity to α-galactosylceramide of NKT cells in the uterus

Cellular Immunology, 2002
It was previously reported that NKT cells, which are mainly present in the liver of mice, are also present in the uterus and that these uterine NKT cells are associated with abortion under overactivated conditions. In this study, we further examined their phenotypic and functional properties. In parallel with the progression of pregnancy, the number of
Sen, Wang, Changchun, Li, Hiroki, Kawamura, Hisami, Watanabe, Toru, Abo   +4 more
openaire   +2 more sources

Distribution of cholesterol and galactosylceramide in rat cerebellar white matter

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
White matter and the inner granular layer of rat cerebellum was analysed by imaging time-of-flight secondary-ion mass spectrometry (TOF-SIMS) equipped with a Bi+ ion cluster gun. Samples were prepared by high pressure freezing, freeze-fracturing and freeze drying or by plunge freezing and cryostat sectioning.
Katrin, Börner, Håkan, Nygren, Birgit, Hagenhoff, Per, Malmberg, Elke, Tallarek, Jan-Eric, Månsson   +5 more
openaire   +2 more sources

Efficient synthesis of galactosylceramide analogues for iNKT cell stimulation

Bioorganic & Medicinal Chemistry Letters, 2010
Glycolipids are potential antigens for iNKT cells recognition and demonstrate important roles in both innate and adaptive immunity. However, the difficulties in the preparation of pure configuration defined glycolipids limit the exploration of their different profiles in activating iNKT cells.
Wenlan, Chen, Chengfeng, Xia, Li, Cai, Peng George, Wang   +3 more
openaire   +2 more sources