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Antigenicity of Galactosylceramide
1986Galactosylceramide (GalC) is the major glycolipid of the central nervous system (CNS) and in adult human myelin it accounts for 23% of the total lipids. The immunological properties of GalC were first detected during the search for a solution to the problem of the immunological specificity of brain lipids. Brandt et al.
B. Zalc +3 more
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A protein activator of galactosylceramide β-galactosidase
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982A heat-stable protein was isolated from the spleen of a patient with Gaucher's disease. This protein will activate glucosylceramide beta-glucosidase activity (Ho, M.W. and O'Brien, J.S. (1971) Proc. Natl. Acad. Sci. U.S.A. 68, 2810-2813). When the specificity of this activator was tested using other enzymes and substrates, it was found to activate ...
D A, Wenger, M, Sattler, S, Roth
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Alpha-galactosylceramide-driven immunotherapy for allergy
Frontiers in Bioscience, 2008We report here that the delivery of both alpha-galactosylceramide (alphaGalCer), a representative ligand for invariant natural killer T (iNKT) cells, and an antigenic polypeptide to marginal zone B cells induces the differentiation of regulatory cells in vivo, and suppresses the secondary antibody responses in mice.
Yasuyuki, Ishii +7 more
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Biochemistry, 1991
The Langmuir film balance technique has been used to define the surface structure and determine the mixing behavior of galactosylceramide (GalCer) and phosphatidylcholines in surface phases. To determine the effect of unsaturation on surface behavior, chain-pure GalCer species containing either oleoyl (18:1 delta 9), eicosenoyl (20:1 delta 11), or ...
S, Ali, H L, Brockman, R E, Brown
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The Langmuir film balance technique has been used to define the surface structure and determine the mixing behavior of galactosylceramide (GalCer) and phosphatidylcholines in surface phases. To determine the effect of unsaturation on surface behavior, chain-pure GalCer species containing either oleoyl (18:1 delta 9), eicosenoyl (20:1 delta 11), or ...
S, Ali, H L, Brockman, R E, Brown
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Occurrence of galactosylceramide in pig epidermal cells
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1988Monoglycosylceramides were isolated from pig epidermal cells which had been prepared free from dermal elements. The most polar glycolipid among the five isolated monoglycosylceramides was galactosylceramide. The galactosylceramide was composed of alpha-hydroxypalmitic acid and 16- and 18-carbon chain sphingenine, being quite different from epidermal ...
S, Hamanaka +3 more
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α-C-Galactosylceramides: Synthesis and Immunology
Accounts of Chemical Research, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Richard W, Franck, Moriya, Tsuji
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Exogenous Galactosylceramide as Potential Treatment for CLN3 Disease
Annals of Neurology, 2019ObjectiveCLN3 disease is the commonest of the neuronal ceroid lipofuscinoses, a group of pediatric neurodegenerative disorders. Functions of the CLN3 protein include antiapoptotic properties and facilitating anterograde transport of galactosylceramide from Golgi to lipid rafts.
Sally El‐Sitt +9 more
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Metabolism of exogenous galactosylceramide in the twitcher mouse brain
Neurochemical Research, 1989The in vivo metabolism of galactosylceramide (gal-cer) in normal mice and in twitcher mice, a model of human GLD, was examined following intracerebral administration of gal-cer containing [1-14C] stearic acid. In normal mice, gal-cer was hydrolyzed to ceramide within 6 hours and ceramide was hydrolyzed to sphingosine and fatty acid.
K, Mitsuo +3 more
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Abnormal accumulation of galactosylceramide in the kidney of twitcher mouse
Biochemical and Biophysical Research Communications, 1983The kidney tissue of the twitcher mice, a neurological mutant caused by a genetic deficiency of galactosylceramidase, contains enormously increased amounts, up to 50 times normal, of galactosylceramide. The finding is in sharp contrast with those in the enzymatically equivalent human disease, globoid cell leukodystrophy (Krabbe disease), in which no ...
H, Igisu +3 more
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Effect of hydrogenation of glucosyl- and galactosylceramide on their enzymatic hydrolysis
Clinica Chimica Acta, 1983Our earlier observation that N-stearoyl- and N-lignoceroyl-glucosyl-dihydro-sphingosines have much lower affinity to the hydrolytic enzyme, glucosylceramidase, than the natural mixture of glucosylceramide [11] has been further pursued with catalytically hydrogenated natural substrate.
A M, Vaccaro, M, Muscillo, K, Suzuki
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