Results 151 to 160 of about 18,858 (204)
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Drugs & Aging, 1996
Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue.
B, Fulton, P, Benfield
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Galanthamine is a selective acetylcholinesterase inhibitor which has shown potential for the treatment of Alzheimer's disease. Galanthamine is selective for acetylcholinesterase versus butyrylcholinesterase; however, the drug produces greater enzyme inhibition in human erythrocytes than in human brain tissue.
B, Fulton, P, Benfield
+5 more sources
A general approach to the galanthamine ring system
Tetrahedron Letters, 2001 An approach to the galanthamine ring system is reported, which utilises an intramolecular Heck reaction to establish the benzofuran ring system present in both galanthamine and morphine.
Philip J Parsons, Adrian Shell
exaly +1 more source
Effect of Fertilizers on Galanthamine and Metabolite Profiles in Narcissus Bulbs by 1H NMR
Journal of Agricultural and Food Chemistry, 2011 Narcissus bulbs contain the biologically active alkaloid galanthamine, and Narcissus is being developed as a natural source of the molecule for the pharmaceutical industry.
Andrea Lubbe +2 more
exaly +3 more sources
Total Synthesis of (±)-Galanthamine
Organic Letters, 2006[reaction: see text] A practical and efficient total synthesis of (+/-)-galanthamine was achieved from commercially available materials through a novel approach, in which the construction of its core structure and the special allylic alcohol group were based on a successive semipinacol rearrangement/desilyation/cyclization and Saegusa-Ito oxidation ...
Xiang-Dong, Hu +7 more
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Cholinesterase inhibition by galanthamine and lycoramine
Biochemical Pharmacology, 1960Abstract Galanthamine, a recently isolated alkaloid, has been found to inhibit the acetylcholinesterase of muscle and the cholinesterase of plasma and brain. The inhibition of the muscle enzyme by galanthamine is greater than that produced by pyridostigmin, a compound of known usefulness, but less than that of neostigmin.
R L, IRWIN, H J, SMITH
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Galanthamine treatment in Alzheimer’s disease
199118 patients who had fulfilled the NINCDS-ADRDA criteria for "possible AD" took part in a clinical study to evaluate the effect of the cholinesterase inhibitor Galanthamine, 30 mg/day. Neuropsychological und social parameters were rated. This open clinical pilot-study showed no statistic significant change in neuropsychological test-results.
P, Dal-Bianco +8 more
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An improved synthesis of galanthamine
Journal of Heterocyclic Chemistry, 1988AbstractModifications in the total synthesis of the Amarylidaceae alkaloid of galanthamine from commercially available isovanillin and tyramine have resulted in a shortened reaction sequence, which is amenable to upscaling and in improved product yield.
Jerzy Szewczyk +2 more
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Total Synthesis of (+)- and (-)-Galanthamine
HETEROCYCLES, 2010The stereoselective total synthesis of (+)-galanthamine [(+)-1], an antipode of the natural product, and (-)-galanthamine [(-)-1] starting from D -glucose is described. The cyclohexene unit in (+)-1 was prepared in an optically active form from D -glucose using Ferrier's carbocyclization reaction, and the benzylic quaternary carbon was ...
Noritaka Chida +2 more
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