Results 161 to 170 of about 18,858 (204)

Daffodil production for galanthamine

2023
Galanthamine is a bioactive that has proven effect to reduce the effect of Alzheimer's. A source of natural galanthamine is from daffodils, but only certain varieties grown under specific conditions produce enough galanthamine to make it economically viable to extract for commercial purposes.
Pyke, Nick, Stephens, Kevin, McLeod, Michaela, Glare, Travis, Narciso, Josefina   +4 more
openaire   +1 more source

Facile synthesis of (±)‐, (+)‐, and (‐)‐galanthamine

Journal of Heterocyclic Chemistry, 1995
AbstractThe Amarylidacea alkaloid galanthamine (1a) is an acetylcholinesterase inhibitor that has been evaluated as a potential agent for the treatment of Alzheimer's disease. We report a very efficent synthesis of (±)‐galanthamine [(±)‐1a] from readily available isovanillin and tyramine.
Jerzy Szewczyk, Joseph W. Wilson, Anita H. Lewin, F. Ivy Carroll   +3 more
openaire   +1 more source

Galanthamine as bis -functional ligand for the acetylcholinesterase

Journal of Molecular Modeling, 2002
Acetylcholinesterase plays a key role in the development of Alzheimer's disease as this enzyme is responsible for cleavage of the neurotransmitter acetylcholine, and, according to recent investigations, also promotes aggregation of beta-amyloid peptides, which causes plaque formation in synaptic areas.
Edgar, Luttmann, Elmar, Linnemann, Gregor, Fels   +2 more
openaire   +2 more sources

Galanthamine

JAMA: The Journal of the American Medical Association, 1978
D A, Cozanitis, E, Toivakka
openaire   +3 more sources

Divergent Enantioselective Synthesis of (−)-Galanthamine and (−)-Morphine

Journal of the American Chemical Society, 2005
An efficient divergent synthetic strategy for the synthesis of the opiate and amaryllidaceae alkaloids emerges by employing a Pd-catalyzed asymmetric allylic alkylation (AAA) to set the stereochemistry. Three generations of syntheses of galanthamine are discussed in detail with particular focus on the scope of the palladium-catalyzed AAA reactions and ...
Barry M, Trost, Weiping, Tang, F Dean, Toste   +2 more
openaire   +2 more sources

Galanthamine in Alzheimer’s Disease

1994
Substantial efforts have been made in neurobiology and molecular biology but we are still far from a causal therapy of Alzheimer’s disease (AD). In the interim, and perhaps ultimately as an adjunct to a progression inhibitor which may not be absolute, symptomatic treatment has to be optimized. Tacrine’s approval by the FDA has stimulated a search for a
Helmut Kewitz, Gordon Wilcock, Bonnie Davis   +2 more
openaire   +1 more source

Wege zu (‐)‐Galanthamin

Nachrichten aus der Chemie, 2004
AbstractEine Zielstruktur, zwei Blickwinkel. Für Forscher aus Industrie und Hochschule zeigt sich die Totalsynthese des Anti‐Alzheimer‐Medikaments (‐)‐Galanthamin ganz unterschiedlich.
openaire   +1 more source

GALANTHAMINE

Targets in Heterocyclic Systems. Vol. 20, 2016
Rinner,, Uwe, Dank, Christian, Hudlicky, Tomas   +2 more
openaire   +1 more source

GALANTHAMINE

1975
Jasjit S. Bindra, Ranjna Bindra
openaire   +1 more source

An Efficient Enantioselective Synthesis of (−)-Galanthamine

Angewandte Chemie, 2002
Barry M, Trost, Weiping, Tang
openaire   +2 more sources