Results 21 to 30 of about 49,688 (258)

Effect of Filgotinib on Body Mass Index (BMI) and Effect of Baseline BMI on the Efficacy and Safety of Filgotinib in Rheumatoid Arthritis

open access: yesRheumatology and Therapy, 2023
Introduction This post hoc analysis of the phase 3 rheumatoid arthritis (RA) filgotinib clinical trial program assessed the effect of filgotinib on body mass index (BMI) in patients with RA and the impact of BMI on the efficacy and safety of filgotinib ...
Alejandro Balsa   +11 more
doaj   +1 more source

Geographic Analysis of the Safety and Efficacy of Filgotinib in Rheumatoid Arthritis

open access: yesRheumatology and Therapy, 2022
Plain Language Summary Clinical trials in rheumatoid arthritis recruit too few patients from diverse ethnic backgrounds to be able to identify differences in treatment outcomes.
Bernard Combe   +6 more
doaj   +1 more source

Preliminary study of the airborne pollen in the atmosphere of Puerto Ayora (Galapagos Islands, Ecuador) [PDF]

open access: yes, 2017
Galapagos is an archipelago of volcanic islands located 972 km west from the continental Ecuador. They were declared by the UNESCO as a World Heritage Site and Biosphere Reserve due to their singular environmental value, where a third part of the ...
Jaramillo Díaz, Patricia   +3 more
core  

Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis

open access: yesArthritis &Rheumatology, Accepted Article.
Background Transition from long‐term denosumab to PTH‐analogs or romosozumab might expose patients to the risk of the so‐called rebound phenomenon. Adding romosozumab to denosumab might represent an option in patients experiencing a fracture while on denosumab.
Giovanni Adami   +10 more
wiley   +1 more source

Back pages of No. 57, 1996 [PDF]

open access: yes, 1996
Charles Darwin Foundation for the Galapagos Islands ...

core  

Measuring the Impact: MRI Response of Sacroiliac Joints to TNF Inhibitors in Youth with Axial Disease

open access: yesArthritis &Rheumatology, Accepted Article.
Objective To evaluate the timeline for resolution of sacroiliac joint (SIJ) inflammation, changes in structural lesions, and their correlation with patient‐reported outcomes in youth with axial juvenile spondyloarthritis (axJSpA) initiating TNF inhibitor (TNFi).
Timothy G. Brandon   +8 more
wiley   +1 more source

Galapagos Tomatoes and Tortoises [PDF]

open access: yesEvolution, 1961
One of the several unique features of tomatoes native to the Galapagos IslandsLycopersicon esculentum var. minor (L. cheesmanii var. minor) and related formsis seed dormancy. Less than one per cent of their seeds, which are notably smaller than those of other known tomatoes, will germinate without treatment.
Charles M. Rick, Robert I. Bowman
openaire   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet   +17 more
wiley   +1 more source

Interactive medical and safety monitoring in clinical trials with clinDataReview: a validated and open-source reporting tool

open access: yesFrontiers in Medicine
Continuous medical and safety monitoring of subject data during a clinical trial is a critical part of evaluating the safety of trial participants and as such is governed by protocol procedures and regulatory guidelines to meet the trial's intended ...
Laure Cougnaud   +7 more
doaj   +1 more source

Priorities for ecological research on cetaceans in the Galápagos Islands

open access: yesFrontiers in Marine Science, 2023
Located in the eastern tropical Pacific, the Galápagos Islands are an oceanic insular ecosystem subject to strong environmental variability driven by local and regional processes.
Daniel M. Palacios   +3 more
doaj   +1 more source

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