Results 21 to 30 of about 12,328 (239)
Tourists and the Seabirds in Galapagos [PDF]
Are the seabird colonies in the Galapagos Islands harmed by the ever increasing numbers of tourists? So far the National Park authorities have been able to safeguard the main nesting grounds from trampling by keeping visitors to prescribed paths, but the birds could be harmed in other ways and these need to be investigated.
openaire +3 more sources
Illegal longline fishing in the Galapagos Marine Reserve (GMR) represents a socioecological issue with significant impact on protected marine species. This study characterizes the use of illegal longlines in the GMR by combining and analyzing datasets ...
Andres Romero-Caicedo +8 more
doaj +1 more source
Introduction This post hoc analysis of the phase 3 rheumatoid arthritis (RA) filgotinib clinical trial program assessed the effect of filgotinib on body mass index (BMI) in patients with RA and the impact of BMI on the efficacy and safety of filgotinib ...
Alejandro Balsa +11 more
doaj +1 more source
In multiple sclerosis (MS), anti‐CD20 therapies have been associated with increased infection risk, but whether this risk differs between rituximab and ocrelizumab is not known. Using a nationwide cohort, we studied infection risk and relapse outcomes among 16,872 treatment episodes with rituximab, ocrelizumab, or other disease‐modifying therapies ...
Thomas Frisell +2 more
wiley +1 more source
Geographic Analysis of the Safety and Efficacy of Filgotinib in Rheumatoid Arthritis
Plain Language Summary Clinical trials in rheumatoid arthritis recruit too few patients from diverse ethnic backgrounds to be able to identify differences in treatment outcomes.
Bernard Combe +6 more
doaj +1 more source
Objective To assess the pharmacokinetics, effectiveness, safety, and immunogenicity of certolizumab pegol (CZP) in polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods Pediatric Arthritis Study of Certolizumab Pegol (NCT01550003), a multicenter, open‐label study, enrolled patients 2–17 years with active pcJIA and inadequate response ...
Hermine I Brunner +28 more
wiley +1 more source
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week (W), double‐blind, placebo‐controlled, phase 3 POETYK PsA‐2 study
Philip J. Mease +20 more
wiley +1 more source
Loss, persistence and reversal of phenotypic traits
ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni +4 more
wiley +1 more source

