Results 81 to 90 of about 49,688 (258)

Comparative Effectiveness and Safety of PI‐Rd Triplets in Relapsed/Refractory Multiple Myeloma: INSIGHT‐MM Data Analysis

European Journal of Haematology, EarlyView.
Assessment of the comparative effectiveness and safety of three PI‐Rd triplets in relapsed/refractory multiple myeloma using data from the global, non‐interventional, observational INSIGHT‐MM study. ABSTRACT Objectives To assess the effectiveness/safety of three proteasome inhibitors (PIs), plus lenalidomide‐dexamethasone (Rd) triplet regimens, for the
Noemi Puig, Xavier Leleu, Hans C. Lee, Faith E. Davies, Roman Hájek, Vania Hungria, Michael A. Thompson, Gordon Cook, Jorge Vela Ojeda, Katja C. Weisel, Jesus G. Berdeja, Saad Z. Usmani, Argiris Symeonidis, Isabel Nascimento‐Ferreira, David Arthur, Lenka Mokrá, Kaili Ren, Dasha Cherepanov, Evangelos Terpos   +18 more
wiley   +1 more source

Long‐term safety and efficacy of secukinumab in paediatric severe plaque psoriasis: 236‐week, Phase 3 trial results

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this Phase III study, secukinumab demonstrated sustained efficacy and a favourable safety profile in paediatric patients with chronic severe plaque psoriasis over a treatment period of 236 weeks. Abstract Background Plaque psoriasis, a chronic inflammatory disease, affects up to 2.1% of the global paediatric population.
Andrzej Kaszuba, Philemon Papanastasiou, Dorota Krasowska, Raul De Lucas Laguna, Michael Ziv, Shoba Ravichandran, Amita Bansal, Swapnil S. Dahale, Ruvie Martin, Bertrand Paguet, Nina Magnolo, Kulli Kingo   +11 more
wiley   +1 more source

Bowel Urgency Improvement Correlates With Clinical, Biochemical, and Intestinal Ultrasound Improvements in Inflammatory Bowel Disease: A Cross Sectional Multicenter Study. [PDF]

United European Gastroenterol J
ABSTRACT Background Bowel urgency (BU) is reported by over 80% of patients with ulcerative colitis (UC) and 60% of those with Crohn's disease (CD). However, the impact of advanced therapies on BU has not been consistently evaluated. Objectives To assess the effect of advanced therapies on BU improvement in patients with UC and CD.
D'Amico F, Nardone OM, Bruno A, Allocca M, Zilli A, Furfaro F, Parigi TL, Solitano V, Ungaro F, Faggiani I, La Mantia A, Calabrese G, Fiorino G, Jairath V, Peyrin-Biroulet L, Massimino L, Castiglione F, Danese S.   +17 more
europepmc   +2 more sources

Stanford oceanographic expedition 17, Galapagos Islands and vicinity, 22 February-23 March 1968: observations on birds, the Galapagos fur seal, and cetaceans [PDF]

, 1968
1. Systematic list of birds (pp. 23-31) 2. Observations on the Galapagos fur seal, Arctocephalus australis galapagoensis Heller, 1904 (pp. 31-33) 3. Cetaceans observed (pp.
Baldridge, Alan
core  

Addiction and chronic skin diseases: A Pan‐European study on prevalence, associations and patient impact

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This pan‐European study reveals high rates of addiction in patients with chronic skin diseases. Smoking, alcohol, drug use, gambling, and internet addiction were prevalent and associated with quality of life, demographics, and region. The findings support integrating addiction screening into dermatologic care to improve outcomes.
Stefanie Ziehfreund, Magdalena Saak, Alisa Schaal, Roxana Mazilu, Emmanuel Mahé, Carla Hajj, Emma K. Johansson, Josefin Lysell, Gunnthorunn Sigurdardottir, Franz J. Legat, Catherina Koch, Astrid Schmieder, Caroline Glatzel, Brian Kirby, Emily Pender, Anna Zalewska‐Janowska, Katarzyna Tomaszewska, Giulia Ciccarese, Pia Lauriola, Michael J. Boffa, Stephanie Farrugia, Anna Caroline Pilz, Franziska Schauer, Magdalena Trzeciak, Weronika Zysk, Krisztián Gáspár, Andrea Szegedi, Giovanni Damiani, Andrea Carugno, Ilona Hartmane, Ingmars Mikazans, Skaidra Valiukeviciene, Livija Petrokaite, Jacek C. Szepietowski, Beata Jastrząb, Petra Staubach, Suzana Ljubojević Hadžavdić, Daška Štulhofer Buzina, Christian Posch, Jakob Jochmann, Antonia Wiala, Ludwig Scheffenbichler, Emanuele Trovato, Laura Calabrese, Gyula Laszlo Fekete, Pavel Chernyshov, Lidiia Kolodzinska, Julia Welzel, Karisa Thölken, Julia‐Tatjana Maul, Lara Valeska Maul, Damian Meyersburg, Stephanie Bowe, Cathal O. Connor, Razvigor Darlenski, Stephan Traidl, Christian Vestergaard, Elena Lucía Pinto‐Pulido, Maria Polina Konstantinou, Eszter Szlávicz, Kristine Heidemeyer, Nikhil Yawalkar, Hanka Agnes Caroline Lantzsch, Aleksandra Soplinska, Anna‐Theresa Seitz, Tiago Torres, Zenon Brzoza, Ana Sanader Vučemilović, Liana Manolache, Nina Magnolo, Emanuele Scala, Kilian Eyerich, Tilo Biedermann, Alexander Zink   +73 more
wiley   +1 more source

Advancing conservation strategies for the endangered Galapagos plant Lecocarpus lecocarpoides: insights from ex situ propagation

Endangered Species Research
The Galapagos Islands, renowned for their unique biodiversity, face a growing crisis, with over half of their endemic vascular plants under threat of extinction. Among the threatened flora, Lecocarpus lecocarpoides is classified as endangered, but is one
A Calle-Loor, P Jaramillo Díaz
doaj   +1 more source

French guidelines on systemic treatments for moderate‐to‐severe psoriasis in adults: Update 2025

Journal of the European Academy of Dermatology and Venereology, EarlyView.
New 2025 French guidelines update psoriasis management with revised algorithms integrating recent systemic therapies. They recommend methotrexate, adalimumab or ustekinumab as first‐line treatments and provide guidance for special psoriasis forms, comorbidities, pregnancy and long‐term management.
Marie Masson Regnault, Emilie Brenaut, Marie‐Emeline Marniquet, Carla Berthault, Lea Canoen, Clarisse Marcombes, Audrey Melin, Raphaël Ouakrat, Julie Charles, Stephane Mouret, Olivier Potie, Laetitia Penso, Laura Pina Vegas, Guillaume Larid, Marine Roux, Colombe Bougeard, Sandy Sylvain, Clara Labonne, Tania Randriamiarana, Da Hee Pitaud, Floriane Etheve, Jeremy Gottlieb, Laurie Gouillon, Marine Chastagner, Emilie Sbidian, Hélène Aubert, on behalf of the Psoriasis Research Group of the French Society of Dermatology (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), Hélène Aubert, Marie Masson Regnault, Emilie Brenaut, Emilie Sbidian, Laura Pina Vegas, Laetitia Penso, Jeremy Gottlieb, Marine Roux, Clara Labonne, Tania Randriamiarana, Floriane Etheve, Da Hee Pitaud, Marie‐Emeline Marniquet, Carla Berthault, Clarisse Marcombes, Audrey Melin, Colombe Bougeard, Julie Charles, Olivier Potie, Léa Canoen, Laurie Gouillon, Marine Chastagner, Sandy Sylvain, Guillaume Larid, Raphaël Ouakrat   +51 more
wiley   +1 more source

Rationale, design and objectives of two phase III, randomised, placebo-controlled studies of GLPG1690, a novel autotaxin inhibitor, in idiopathic pulmonary fibrosis (ISABELA 1 and 2)

BMJ Open Respiratory Research, 2019
Introduction While current standard of care (SOC) for idiopathic pulmonary fibrosis (IPF) slows disease progression, prognosis remains poor. Therefore, an unmet need exists for novel, well-tolerated agents that reduce lung function decline and improve ...
Kevin K Brown, Toby M Maher, Michael Kreuter, David J Lederer, Wim Wuyts, Nadia Verbruggen, Simone Stutvoet, Ann Fieuw, Paul Ford, Walid Abi-Saab, Marlies Wijsenbeek   +10 more
doaj   +1 more source

Week One in the Galapagos [PDF]

, 2016
Postcard from Michael McGrath, during the Linfield College Semester Abroad Program at the Galápagos Academic Institute of the Arts and Sciences in the Galápagos Islands ...
McGrath, Michael
core   +1 more source

Nemolizumab in prurigo nodularis up to 100 weeks: OLYMPIA LTE interim analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this interim analysis of the OLYMPIA long‐term extension trial, nemolizumab exhibited sustained efficacy and was well tolerated through 100 weeks, with most adverse events being mild/moderate. Patients showed clinically meaningful improvements in core signs and symptoms.
Franz J. Legat, Shawn G. Kwatra, Adam Reich, Serge Boulinguez, Athanasios Tsianakas, Maxwell Sauder, Sebastien Barbarot, Jacek C. Szepietowski, Curdin Conrad, Andrew E. Pink, Elke Weisshaar, Laurent Misery, Martin Metz, Vivian T. Laquer, Raja K. Sivamani, Gil Yosipovitch, Diamant Thaçi, Lone Skov, Xiaoxiao Chen, Aliene Noda, Zarif K. Jabbar‐Lopez, Christophe Piketty, Sonja Ständer   +22 more
wiley   +1 more source