Results 1 to 10 of about 70,530 (251)
Plasma Galectin-7 (Gal-7) and Galectin-8 (Gal-8) as Emerging Biomarkers in Psoriasis: Associations with Disease Activity and Metabolic Status [PDF]
MetabolitesBackground: Psoriasis is a chronic, immune-mediated skin disorder characterized by accelerated epidermal turnover. Galectins are a family of carbohydrate-binding proteins that play crucial roles in various biological processes.
Julia Nowowiejska-Purpurowicz +6 more
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Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin [PDF]
Molecular MedicineThe galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral +8 more
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Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
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Enhancing clinical and immunological effects of anti-PD-1 with belapectin, a galectin-3 inhibitor
Journal for ImmunoTherapy of Cancer, 2021 Background PD-1/PD-L1 engagement and overexpression of galectin-3 (Gal-3) are critical mechanisms of tumor-induced immune suppression that contribute to immunotherapy resistance. We hypothesized that Gal-3 blockade with belapectin (GR-MD-02) plus anti-PD-
William L Redmond +12 more
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Molecular Therapy: Nucleic Acids, 2023 Non-DNA-binding Stabilin-2/HARE receptors expressed on liver sinusoidal endothelial cells specifically bind to and internalize several classes of phosphorothioate antisense oligonucleotides (PS-ASOs).
Ekta Pandey, Edward N. Harris
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Evaluation of galectins 1 and 3 expression in canine melanoma [PDF]
Pesquisa Veterinária Brasileira, 2021 : Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins.
Jéssica S. Garcia +6 more
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Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues
Biomolecules, 2021 Galectins comprise a family of soluble β-galactoside-binding proteins, which regulate a variety of key biological processes including cell growth, differentiation, survival, and death.
Jennifer D. Kaminker +1 more
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Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. [PDF]
PLoS ONE, 2014 Patients with primary aldosteronism are associated with increased myocardial fibrosis. Galectin-3 is one of the most important mediators between macrophage activation and myocardial fibrosis.To investigate whether aldosterone induces galectin-3 secretion
Yen-Hung Lin +11 more
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Journal of Extracellular Vesicles, 2022 Breast cancer cells release a large quantity of biocargo‐bearing extracellular vesicles (EVs), which mediate intercellular communication within the tumour microenvironment and promote metastasis.
Daniel Xin Zhang +16 more
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Molecules, 2021 Lipid membranes are common to all forms of life. While being stable barriers that delimitate the cell as the fundamental organismal unit, biological membranes are highly dynamic by allowing for lateral diffusion, transbilayer passage via selective ...
Ludger Johannes
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