Results 101 to 110 of about 36,130 (196)

T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance [PDF]

, 2014
T cell differentiation is dictated by a combination of T cell receptor (TCR) interaction with an antigen-bound major histocompatibility complex (MHC), and co-stimulatory molecules signal.
Abdoli, R., Najafian, N.
core  

Consequences of cystic fibrosis transmembrane regulator mutations on inflammatory cells [PDF]

, 2016
Recent studies in cystic fibrosis (CF) transmembrane regulator (CFTR) mutations and function have shed light on its involvement in disease progression. The extent of cell and tissue distribution of CFTR facilitates systemic dysfunction of ion transport ...
Castro, Guillermo Raul, Grumelli, Sandra, Islan, German Abel   +2 more
core   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Modulators of the Balance between M1 and M2 Macrophages during Pregnancy [PDF]

, 2017
Macrophages are a subset of mononuclear phagocytes of the innate immune system with high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present in all stages of pregnancy and involved in a variety of activities, including ...
Ai-Hua Liao, Ming He, Yan Wang, Yong-Hong Zhang   +3 more
core   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Interrogation of glioma immune microenvironment identifies a non-canonical role for microglial Galectin-9 in tumor cell adhesion and phagocytosis

Frontiers in Immunology
Glioma-associated microglia/macrophages (GAMs) have traditionally been described as immunosuppressive. However, within their highly heterogeneous repertoire, pro-phagocytic and cytotoxic subsets with anti-tumoral properties exist.
Pravesh Gupta, Silvana Valdebenito-Silva, Gayatri Kumar, Prashanth Chakrapani, Shivangi Oberai, Shivangi Oberai, Minghao Dang, Hiroshi Katayama, Linghua Wang, Linghua Wang, Linghua Wang, Linghua Wang, Eliseo A. Eugenin, Krishna P. Bhat   +13 more
doaj   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

OncoImmunology, 2019
Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells modulates tumor cell adhesion, metastasis, and apoptosis.
Pietro Bertino, Thomas A. Premeaux, Tsuyoshi Fujita, Brien K. Haun, Michael P. Marciel, Fukun W. Hoffmann, Alan Garcia, Haining Yiang, Sandra Pastorino, Michele Carbone, Toshiro Niki, John Berestecky, Peter R. Hoffmann, Lishomwa C. Ndhlovu   +13 more
doaj   +1 more source

Az anya immunológiai tolerancia mechanizmusai a terhesség során és azok zavarai pathológiás terhességekben: pre-eclampsiás és habituálisan vetélő betegek vizsgálata = The mechanisms of immunological tolerance during pregnancy: impaired maternal tolerance during pre-eclampsia and habitual abortion [PDF]

, 2011
Sikeres és sikertelen mesterséges megtermékenyítésen (IVF) átesett nők perifériás NK és NKT sejtjeinek fenotípusát és funkcióját vizsgáltuk. Követéses vizsgálat során a beavatkozás előtt és után nyert adatokat hasonlítottuk össze.
Barakonyi, Aliz, Halász, Melinda, Mikó, Éva, Szereday, László   +3 more
core