Results 101 to 110 of about 4,258,326 (225)
Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion
OncoImmunology, 2019 Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells modulates tumor cell adhesion, metastasis, and apoptosis.
Pietro Bertino +13 more
doaj +1 more source
SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies
PROTEOMICS, EarlyView.ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà +10 more
wiley +1 more source
Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways
, 2008 The galectin family of lectins regulates multiple biologic functions, such as development, inflammation, immunity, and cancer. One common function of several galectins is the ability to trigger T cell death.
Shuguang Bi +7 more
core +1 more source
Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping
The Chemical Record, EarlyView.Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato +3 more
wiley +1 more source
Galectin-9 activates and expands human T-helper cells.
, 2013 Galectin-9 (Gal-9) is known for induction of apoptosis in IFN-c and IL-17 producing T-cells and amelioration of autoimmunity in murine models. On the other hand, Gal-9 induced IFN-c positive T-cells in a sarcoma mouse model and in food allergy ...
P Eggleton (21818144) +8 more
core
VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
wiley +1 more source
Integrative Zoology, EarlyView.High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang +6 more
wiley +1 more source
The Role of Galectin-3 in Th17 Differentiation
, 2010 第十七型輔助型T細胞 (T helper 17 cells, Th17 cells)，一個最近被大量研究的輔助型T細胞分支，在病理上被認為是導致自體免疫疾病的主要原因之一。在Th17的細胞分化以及生理作用上,之前研究中已提供許多方面深入的探討。然而在Th17細胞之負向調控機制上，則相對的較缺乏清楚的了解並且仍需要更多的研究。 在此研究中我們發現，與野生控制組相比，Galectin-3基因剔除之輔助型T細胞於體外分化時較容易且大量的分化至Th17細胞，伴隨著主要分泌之細胞激素( IL-17, IL-21 )
朱安翔, Chu, An-Hsiang
core
Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection
, 2016 Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins.
Po-Lin Kuo +6 more
core +1 more source
Allergy, EarlyView.ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh +7 more
wiley +1 more source