Results 121 to 130 of about 43,144 (243)

Predictive biomarkers for checkpoint inhibitor-based immunotherapy: The Galectin-3 signature in NSCLCs [PDF]

, 2019
Checkpoint inhibitor-based immunotherapy is opening a promising scenario in oncology, with objective responses registered in multiple cancer types. However, reliable predictive markers of tumor responsiveness are still lacking.
Bartolazzi A., Capalbo C., Filetti M., Marchetti P., Scafetta G.   +4 more
core   +1 more source

Effect of steroids on transcription and secretion of Gal-1 by the human trophoblast cell line in vitro [PDF]

, 2013
Galectin-1 (Gal-1) is a lectin with recently documented pro-invasive function in trophoblasts in vitro, whose regulation is currently insufficiently known.
Bojić-Trbojević Žanka, Pavlović Sonja, Tošić Nataša, Vićovac Ljiljana, Ćujić Danica   +4 more
core   +1 more source

Sensing ligand binding to a clinically relevant lectin by tryptophan fluorescence anisotropy [PDF]

, 2011
Increasing insights into the involvement of endogenous lectins in disease processes fuel the interest to develop potent inhibitors. As a consequence, robust assay procedures are required. Due to their activity as adhesion/growth-regulatory effectors this
André, Sabine, Büchner, Claudia, Doose, Sören, Gabius, Hans-Joachim, Göhler, Antonia, Kaltner, Herbert   +5 more
core   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Effect of galectin‐1 on prognosis and responsiveness of immune checkpoint plus tyrosine kinase inhibition in renal cell carcinoma

Cancer Medicine
Background In renal cell carcinoma (RCC), no clinically available biomarker has been utilized for checkpoint inhibitor immunotherapy (IO) + tyrosine kinase inhibitor (TKI) combinations.
Jiajun Wang, Sihong Zhang, Ying Wang, Yanjun Zhu, Xianglai Xu, Jianming Guo   +5 more
doaj   +1 more source

Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity

Retrovirology, 2008
Background Cell-free Human T-cell Leukemia Virus type I (HTLV-I) virions are poorly infectious and cell-to-cell contact is often required to achieve infection. Other factors might thus importantly contribute in increasing infection by HTLV-I.
Sato Sachiko, Tremblay Michel J, Vargas Amandine, Ouellet Michel, Pelletier Isabelle, Gauthier Sonia, Barbeau Benoit   +6 more
doaj   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]

, 2015
Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara, Chan, Philippe, Ghezzi, Pietro, Hammouz, Raneem, Mullen, Lisa, Seavill, Miles, Vaudry, David   +6 more
core   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Glycobiology of cell death: when glycans and lectins govern cell fate [PDF]

, 2013
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death.
A Büssing, A Shiratsuchi, A Sturm, AF Carlin, AF Swindall, B Brandt, BE Britigan, BN Stillman, C Lazar, C Villeneuve, C Zhu, CA Gabel, CF Brewer, D Paclik, E Cao, E Charlier, E Duvall, E Rapoport, EM Rapoport, F Bernerd, F Dall’Olio, F Gu, F Yu, FA Barr, FT Liu, G A Rabinovich, G Ion, G Majai, G Yogalingam, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GC Fernández, GD Griffiths, GR Vasta, H Ise, H Sano, H Sano, HM Meesmann, HP Hahn, I Bournazou, I Kuwabara, JA Fulcher, JD Hernandez, JD Marth, JF Kerr, JH Lin, JT Nguyen, K Kollmann, K Lauber, K Moriwaki, K Moriwaki, K Suzuki, KE Pace, KW Wagner, L Eshkar Sebban, LA Earl, LC Paessens, LH Lu, LL Fu, M Cohen, M Dias-Baruffi, M Molinari, M Pang, M Rangachari, MA Toscano, MC Maiuri, ME Peter, ML Litvack, MM Fuster, MM Weck, MU Hutchins, N Maugeri, N Mazurek, N Mazurek, N Mazurek, N Oka, N Sharon, NB Caberoy, OM Shatnyeva, OT Keppler, P Desharnais, P Matarrese, P Schneider, P Smits, R G Lichtenstein, R Hanayama, R Hanayama, RA Lockshin, RG Morris, RS Maag, RY Yang, S Arur, S Eda, S Gupta, S Li, S Mukherjee, S Toda, S Wesselborg, SC Starossom, SJ Van Dyken, SJ Van Vliet, SR Stowell, SR Stowell, T Fukumori, T Fukumori, TL Schagat, TL Thurston, V Wells, VA Fadok, VM Abrahams, X Li, Y Kashio, Y Oda, Y Wang, Y Watanabe, Y Watanabe, Y Zhuo, YJ Lee, Z Liu, ZN Oltvai   +123 more
core   +2 more sources