Results 221 to 230 of about 29,735,201 (297)

The Immunomodulatory Role of Galectin-1 in the Tumour Microenvironment and Strategies for Therapeutic Applications. [PDF]

Cancers (Basel)
Griffiths A, Udomjarumanee P, Georgescu AS, Barri M, Zinovkin DA, Pranjol MZI.   +5 more
europepmc   +1 more source

Integrating Conventional and Emerging Approaches in Cardiovascular Risk Assessment and Management

Public Health Challenges, Volume 5, Issue 3, September 2026.
Conventional risk factors (hypertension, dyslipidaemia, diabetes, smoking, obesity and physical inactivity) account for roughly 70% of population‐attributable cardiovascular risk and anchor a proposed three‐tier pathway: universal low‐cost assessment (Tier 1), selective testing such as hsCRP or PRS where it would change management (Tier 2) and resource‐
Sana Rasheed, Azka Mujeeb, Misbah Sarfraz, Abedin Samadi, Ahmed Asad Raza   +4 more
wiley   +1 more source

Unraveling the GM₁ Specificity of Galectin‑1 Binding to Lipid Membranes. [PDF]

ACS Bio Med Chem Au
Scollo F, Kulig W, Nicita G, Ludwig AK, Ricardo JC, Zito V, Kapusta P, Vattulainen I, Cebecauer M, Gabius HJ, Kaltner H, Maccarrone G, Hof M.   +12 more
europepmc   +1 more source

Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

Aging Cell, Volume 25, Issue 9, September 2026.
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao, Xudong Cha, Yingqi Xie, Enhao Wang, Wenlu Xing, Zengyi Xu, Langchao Liang, Changhai Xiong, Morong Zhou, Penghui Fu, Zhe Wang, Xin Liu, Yiqun Yu, Huanhai Liu, Hanbo Li, Wenwen Ren   +15 more
wiley   +1 more source

Galectin-1 in Cardiovascular Pathogenesis: Unraveling Dual Roles and Mechanistic Insights in Emerging Research. [PDF]

Medicina (Kaunas)
Chen PY, Cheng CY, Chen CC, Chen HY, Liu JC, Hao WR, Cheng TH, Chen JJ.   +7 more
europepmc   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, Volume 81, Issue 9, Page 3171-3184, September 2026.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Galectin-1 modulates glycolysis through a GM1-galactose-dependent pathway to promote hyperthermia resistance in HCC. [PDF]

Hepatology
Nguyen T, Shin Y, Ruppa A, Krall AS, Pham J, Chen PC, Mirmohammadi H, Keshavarz P, Finn RS, Agopian VG, French SW, Christofk HR, Lu DSK, Raman SS, Chiang J.   +14 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, Volume 59, Issue 9, September 2026.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Galectin-1 as a potential biomarker of rheumatoid arthritis drug effectiveness. [PDF]

Int J Immunopathol Pharmacol
Krstić N, Jevtović Stoimenov T, Stojanović S, Đorđević B, Damnjanović I.   +4 more
europepmc   +1 more source