Results 231 to 240 of about 42,532 (255)

Galectin-1 plays essential roles in adult mammalian nervous tissues. Roles of oxidized galectin-1

Glycoconjugate Journal, 2002
Previous data have suggested that galectin-1 is expressed widely in nervous tissues at embryonic stages but becomes restricted mainly to peripheral nervous tissues with maturation. Though the expression is intense in adult mammalian peripheral neurons, there had been no report about functions of galectin-1 there.
Hidenori, Horie, Toshihiko, Kadoya
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Characterisation of Oxidized Recombinant Human Galectin-1

Protein & Peptide Letters, 2009
Oxidized human galectin-1 plays a role in the immune response to injured axons. Over-expression of galectin-1 by cancer, in combination with cancer associated oxidative stress suggests oxidized human galectin-1 may also play a role(s) in tumourigenesis.
Scott, Stacy A, Bugarcic, Andrea, Blanchard, Helen   +2 more
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Galectin-1 and HIV-1 Infection

2010
Initial binding of human immunodeficiency virus-1 (HIV-1) to its susceptible CD4(+) cells is the limiting step for the establishment of infection as the avidity of viral envelope gp120 for CD4 is not high and the number of viral envelope spikes on the surface is found to be low compared to highly infectious viruses. Several host factors, such as C-type
Christian, St-Pierre, Michel, Ouellet, Michel J, Tremblay, Sachiko, Sato   +3 more
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Galectin-1 binds mucin in human trophoblast

Histochemistry and Cell Biology, 2014
Mucins are multifunctional highly glycosylated proteins expressed by the female reproductive tract. Differential expression of MUC1 and MUC15 has been shown in trophoblast. This study was undertaken to establish the distribution of mucin(s) in cytotrophoblast cell cultures using anti-bovine submaxillary mucin (BSM) and to investigate the possibility of
Zanka, Bojić-Trbojević, Milica, Jovanović Krivokuća, Nikola, Kolundžić, Miloš, Petronijević, Svetlana, Vrzić-Petronijević, Snežana, Golubović, Ljiljana, Vićovac   +6 more
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Galectin-1 and immunotherapy for brain cancer

Expert Review of Neurotherapeutics, 2011
The prognosis of patients diagnosed with high-grade glioma continues to be dismal in spite of multimodal treatment. Active specific immunotherapy by means of dendritic cell vaccination is considered to be a new promising concept that aims at generating an anti-tumoral immune response.
Verschuere, Tina, De Vleeschouwer, Steven, Lefranc, Florence, Kiss, Robert, Van Gool, Stefaan W   +4 more
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Galectin‐1 studies in proliferative diabetic retinopathy

Acta Ophthalmologica, 2019
AbstractPurposeGalectin‐1 regulates endothelial cell function and promotes angiogenesis. We investigated the hypothesis that galectin‐1 may be involved in the pathogenesis of proliferative diabetic retinopathy (PDR).MethodsVitreous samples from 36 PDR and 20 nondiabetic patients, epiretinal fibrovascular membranes from 13 patients with PDR, rat retinas
Ahmed M. Abu El‐Asrar, Ajmal Ahmad, Eef Allegaert, Mohammad Mairaj Siddiquei, Kaiser Alam, Priscilla W. Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
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Galectin-1 and Immune Suppression during Radiotherapy

Clinical Cancer Research, 2014
Abstract Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8+ T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.
James W, Welsh, Steven N, Seyedin, Maria Angelica, Cortez, Amit, Maity, Stephen M, Hahn   +4 more
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Galectin-1 in Stable Liver Transplant Recipients

Transplantation Proceedings, 2015
The achievement of a state of tolerance and minimization of the immunosuppressive load form part of the "Holy Grail" in solid organ transplantation. Galectin-1 recently has been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation.
M J, García, F, Jurado, D, San Segundo, M, López-Hoyos, P, Iruzubieta, S, Llerena, F, Casafont, M, Arias, Á, Puente, J, Crespo, E, Fábrega   +10 more
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Intracellular Glycoproteins Binding Galectin-1 in Thyroid Lesions

Tumori Journal, 2009
Aims and background The increased expression of galectin-1 on the mRNA and protein level observed in malignant thyroid tumors in comparison with benign lesions suggests that this protein may be associated with malignant transformation of thyroid epithelium.
Zuzanna Gaj, Anna Krzeslak, Lech Pomorski, Anna Lipinska   +3 more
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The immunological potential of galectin-1 and -3

Autoimmunity Reviews, 2009
A family of beta-galactosides-binding proteins, called galectins, have recently emerged as novel molecules with immunoregulatory functions. These proteins are expressed in both inflammatory and non-inflammatory cells including monocytes, macrophages, dendritic cells, mast cells, and B and T cells, giving a broad spectrum of involvement in the immune ...
A. Dhirapong, A. Lleo de Nalda, P. Leung, M. E. Gershwin, F. T. Liu   +4 more
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