Results 251 to 260 of about 21,276,578 (296)
Taloside Inhibitors of Galectin‐1 and Galectin‐3
Chemical Biology & Drug Design, 2012 Galectin‐1 and galectin‐3 have roles in cancer and inflammation. Galectin‐1 has recently emerged as a significant protein produced by tumour cells to promote tumour development, angiogenesis and metastasis and consequently represents an important target to inhibit.
Collins, Patrick M +4 more
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Galectin‐1 in regenerating motoneurons
European Journal of Neuroscience, 2004AbstractThe exogenous application of recombinant galectin‐1 has recently been shown to promote the rate of peripheral nerve regeneration. Endogenous neuronal galectin‐1 expression has recently been demonstrated to increase after axotomy. Here we demonstrate a significant increase in the endogenous neuronal expression of galectin‐1 mRNA in facial ...
J, McGraw +7 more
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The immunological potential of galectin-1 and -3
Autoimmunity Reviews, 2009A family of beta-galactosides-binding proteins, called galectins, have recently emerged as novel molecules with immunoregulatory functions. These proteins are expressed in both inflammatory and non-inflammatory cells including monocytes, macrophages, dendritic cells, mast cells, and B and T cells, giving a broad spectrum of involvement in the immune ...
A. Dhirapong +4 more
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Galectin-1 and immunotherapy for brain cancer
Expert Review of Neurotherapeutics, 2011The prognosis of patients diagnosed with high-grade glioma continues to be dismal in spite of multimodal treatment. Active specific immunotherapy by means of dendritic cell vaccination is considered to be a new promising concept that aims at generating an anti-tumoral immune response.
Verschuere, Tina +4 more
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Characterisation of Oxidized Recombinant Human Galectin-1
Protein & Peptide Letters, 2009Oxidized human galectin-1 plays a role in the immune response to injured axons. Over-expression of galectin-1 by cancer, in combination with cancer associated oxidative stress suggests oxidized human galectin-1 may also play a role(s) in tumourigenesis.
Scott, Stacy A +2 more
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Galectin-1 and HIV-1 Infection
2010Initial binding of human immunodeficiency virus-1 (HIV-1) to its susceptible CD4(+) cells is the limiting step for the establishment of infection as the avidity of viral envelope gp120 for CD4 is not high and the number of viral envelope spikes on the surface is found to be low compared to highly infectious viruses. Several host factors, such as C-type
Christian, St-Pierre +3 more
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Glycoprotein 90K/MAC‐2BP interacts with galectin‐1 and mediates galectin‐1–induced cell aggregation
International Journal of Cancer, 2001The glycoprotein 90K was originally described as a tumor-secreted antigen and subsequently found to have immunostimulatory activity as well as other possible functions. This protein interacts with an endogenous lectin, galectin-3, and may play a role in tumor metastasis through this interaction. Because 90K is heavily glycosylated, it may also interact
TINARI, Nicola +5 more
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Galectin-1 plays essential roles in adult mammalian nervous tissues. Roles of oxidized galectin-1
Glycoconjugate Journal, 2002Previous data have suggested that galectin-1 is expressed widely in nervous tissues at embryonic stages but becomes restricted mainly to peripheral nervous tissues with maturation. Though the expression is intense in adult mammalian peripheral neurons, there had been no report about functions of galectin-1 there.
Hidenori, Horie, Toshihiko, Kadoya
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