Results 261 to 270 of about 29,735,201 (297)

Galectin-1 plays essential roles in adult mammalian nervous tissues. Roles of oxidized galectin-1

Glycoconjugate Journal, 2002
Previous data have suggested that galectin-1 is expressed widely in nervous tissues at embryonic stages but becomes restricted mainly to peripheral nervous tissues with maturation. Though the expression is intense in adult mammalian peripheral neurons, there had been no report about functions of galectin-1 there.
Hidenori, Horie, Toshihiko, Kadoya
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High glucose‐induced Galectin‐1 in human podocytes implicates the involvement of Galectin‐1 in diabetic nephropathy

Cell Biology International, 2014
AbstractThe diabetic milieu is believed to change the activity, or result in damage of podocytes—a key component of the glomerular filtration barrier and known to secrete matrix for glomerular basement membrane. This in turn contributes to diabetic nephropathy.
Yinghong, Liu, Luping, Long, Fang, Yuan, Fuyou, Liu, Hong, Liu, Youming, Peng, Lin, Sun, Guochun, Chen   +7 more
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Structural and Functional Studies of Galectin-1: A Novel Axonal Regeneration-Promoting Activity for Oxidized Galectin-1

Current Drug Targets, 2005
Recently, we discovered oxidized galectin-1 as a factor that regulates initial axonal growth in the peripheral nerve after axotomy. Galectin-1 is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the ...
Toshihiko, Kadoya, Hidenori, Horie
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Galectin‐1 production is elevated in hypertrophic scar

Wound Repair and Regeneration, 2020
AbstractUpon healing, burn wounds often leave hypertrophic scars (HTSs) marked by excess collagen deposition, dermal and epidermal thickening, hypervascularity, and an increased density of fibroblasts. The Galectins, a family of lectins with a conserved carbohydrate recognition domain, function intracellularly and extracellularly to mediate a multitude
Liam D. Kirkpatrick, Jeffrey W. Shupp, Robert D. Smith, Abdulnaser Alkhalil, Lauren T. Moffatt, Bonnie C. Carney   +5 more
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Characterization of the Interaction of Galectin-1 with Sodium Arsenite

Chemical Research in Toxicology, 2006
We previously showed that galectin-1 (GAL1) is an arsenic-binding protein. In the current study, we further characterize the interaction of GAL1 with sodium arsenite (As(III)). The GALl-As(III) complex was prepared from the cell extracts of GAL1-transfected Escherichia coli (E. coli) that were pretreated with As(III).
Lin, C. H., Huang, C. F., Chen, W. Y., Lin, M. S., Chang, Y. Y., Wu, S. H., Ding, W. H., Huang, R. N.   +7 more
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Galectin-1 in Stable Liver Transplant Recipients

Transplantation Proceedings, 2015
The achievement of a state of tolerance and minimization of the immunosuppressive load form part of the "Holy Grail" in solid organ transplantation. Galectin-1 recently has been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation.
M J, García, F, Jurado, D, San Segundo, M, López-Hoyos, P, Iruzubieta, S, Llerena, F, Casafont, M, Arias, Á, Puente, J, Crespo, E, Fábrega   +10 more
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Tissue fibronectin is an endogenous ligand for galectin-1

Glycobiology, 1995
A 14K beta-galactoside-binding lectin (galectin-1) is present in many animal tissues. In a search for endogenous ligands, we surveyed galectin-1-binding proteins in human placenta. Extract of human placenta with 2 M urea was applied to a Sepharose 4B column conjugated with galectin-1 purified from frog (Rana catesbeiana) eggs. Two major proteins eluted
Y, Ozeki, T, Matsui, Y, Yamamoto, M, Funahashi, J, Hamako, K, Titani   +5 more
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Galectin-1 and Immune Suppression during Radiotherapy

Clinical Cancer Research, 2014
Abstract Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8+ T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.
James W, Welsh, Steven N, Seyedin, Maria Angelica, Cortez, Amit, Maity, Stephen M, Hahn   +4 more
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Apoptosis of T cells mediated by galectin-1

Nature, 1995
Galectin-1, a member of the family of beta-galactoside binding proteins, has growth regulatory and immunomodulatory activities. We report here that galectin-1, expressed by stromal cells in human thymus and lymph nodes, is present at sites of cell death by apoptosis during normal T-cell development and maturation.
N L, Perillo, K E, Pace, J J, Seilhamer, L G, Baum   +3 more
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Galectin-1: A bifunctional regulator of cellular proliferation

Glycoconjugate Journal, 2002
Galectin-1 has demonstrated a diverse range of activities in relation to cell survival and proliferation. In different circumstances, it acts as a mitogen, as an inhibitor of cell proliferation, and as a promoter of cellular apoptosis. Many of these activities, particularly the mitogenic and apoptotic responses, follow from the interaction of galectin ...
Ken, Scott, Cristina, Weinberg
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