Results 261 to 270 of about 21,276,578 (296)

Galectin‐1 production is elevated in hypertrophic scar

Wound Repair and Regeneration, 2020
AbstractUpon healing, burn wounds often leave hypertrophic scars (HTSs) marked by excess collagen deposition, dermal and epidermal thickening, hypervascularity, and an increased density of fibroblasts. The Galectins, a family of lectins with a conserved carbohydrate recognition domain, function intracellularly and extracellularly to mediate a multitude
Liam D. Kirkpatrick, Jeffrey W. Shupp, Robert D. Smith, Abdulnaser Alkhalil, Lauren T. Moffatt, Bonnie C. Carney   +5 more
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Structural and Functional Studies of Galectin-1: A Novel Axonal Regeneration-Promoting Activity for Oxidized Galectin-1

Current Drug Targets, 2005
Recently, we discovered oxidized galectin-1 as a factor that regulates initial axonal growth in the peripheral nerve after axotomy. Galectin-1 is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the ...
Toshihiko, Kadoya, Hidenori, Horie
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High glucose‐induced Galectin‐1 in human podocytes implicates the involvement of Galectin‐1 in diabetic nephropathy

Cell Biology International, 2014
AbstractThe diabetic milieu is believed to change the activity, or result in damage of podocytes—a key component of the glomerular filtration barrier and known to secrete matrix for glomerular basement membrane. This in turn contributes to diabetic nephropathy.
Yinghong, Liu, Luping, Long, Fang, Yuan, Fuyou, Liu, Hong, Liu, Youming, Peng, Lin, Sun, Guochun, Chen   +7 more
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Characterization of the Interaction of Galectin-1 with Sodium Arsenite

Chemical Research in Toxicology, 2006
We previously showed that galectin-1 (GAL1) is an arsenic-binding protein. In the current study, we further characterize the interaction of GAL1 with sodium arsenite (As(III)). The GALl-As(III) complex was prepared from the cell extracts of GAL1-transfected Escherichia coli (E. coli) that were pretreated with As(III).
Lin, C. H., Huang, C. F., Chen, W. Y., Lin, M. S., Chang, Y. Y., Wu, S. H., Ding, W. H., Huang, R. N.   +7 more
openaire   +2 more sources

Galectin-1: A bifunctional regulator of cellular proliferation

Glycoconjugate Journal, 2002
Galectin-1 has demonstrated a diverse range of activities in relation to cell survival and proliferation. In different circumstances, it acts as a mitogen, as an inhibitor of cell proliferation, and as a promoter of cellular apoptosis. Many of these activities, particularly the mitogenic and apoptotic responses, follow from the interaction of galectin ...
Ken, Scott, Cristina, Weinberg
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Tissue fibronectin is an endogenous ligand for galectin-1

Glycobiology, 1995
A 14K beta-galactoside-binding lectin (galectin-1) is present in many animal tissues. In a search for endogenous ligands, we surveyed galectin-1-binding proteins in human placenta. Extract of human placenta with 2 M urea was applied to a Sepharose 4B column conjugated with galectin-1 purified from frog (Rana catesbeiana) eggs. Two major proteins eluted
Y, Ozeki, T, Matsui, Y, Yamamoto, M, Funahashi, J, Hamako, K, Titani   +5 more
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Expression and Functions of Galectin-1 in Sensory and Motoneurons

Current Drug Targets, 2005
Galectin-1 (Gal1) was the first identified member of the galectin family of beta-galactosidase-binding proteins. Gal1 has important roles in processes fundamental to growth and survival of an organism, including cell adhesion, cell proliferation and apoptosis, and is expressed in many tissues, including the nervous system.
A D, Gaudet, J D, Steeves, W, Tetzlaff, M S, Ramer   +3 more
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Galectin‐1 studies in proliferative diabetic retinopathy

Acta Ophthalmologica, 2019
AbstractPurposeGalectin‐1 regulates endothelial cell function and promotes angiogenesis. We investigated the hypothesis that galectin‐1 may be involved in the pathogenesis of proliferative diabetic retinopathy (PDR).MethodsVitreous samples from 36 PDR and 20 nondiabetic patients, epiretinal fibrovascular membranes from 13 patients with PDR, rat retinas
Ahmed M. Abu El‐Asrar, Ajmal Ahmad, Eef Allegaert, Mohammad Mairaj Siddiquei, Kaiser Alam, Priscilla W. Gikandi, Gert De Hertogh, Ghislain Opdenakker   +7 more
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Galectin-1 in Stable Liver Transplant Recipients

Transplantation Proceedings, 2015
The achievement of a state of tolerance and minimization of the immunosuppressive load form part of the "Holy Grail" in solid organ transplantation. Galectin-1 recently has been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation.
M J, García, F, Jurado, D, San Segundo, M, López-Hoyos, P, Iruzubieta, S, Llerena, F, Casafont, M, Arias, Á, Puente, J, Crespo, E, Fábrega   +10 more
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Galectin-1: Forms and Functions

2012
Galectin-1 (Gal-1) is an animal lectin ranging from Caenorhabditis elegans to humans, which is defined by the affinity for β-galactosides and by significant sequence similarity in carbohydrate-binding site. Gal-1 is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of ...
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