Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin [PDF]
Molecular MedicineThe galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral +8 more
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Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]
, 2017 Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti +3 more
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Evaluation of galectins 1 and 3 expression in canine melanoma [PDF]
Pesquisa Veterinária Brasileira, 2021 : Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins.
Jéssica S. Garcia +6 more
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Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. [PDF]
PLoS ONE, 2014 Patients with primary aldosteronism are associated with increased myocardial fibrosis. Galectin-3 is one of the most important mediators between macrophage activation and myocardial fibrosis.To investigate whether aldosterone induces galectin-3 secretion
Yen-Hung Lin +11 more
doaj +1 more source
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
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Current Issues in Molecular Biology, 2023 Numerous studies have considered galectin-3 or Glycogen synthase kinase 3 beta (GSK3B) as a potential prognosis marker for various cancers. However, the correlation between the protein expression of galectin-3/GSK3B and the clinical parameters of ...
Hung-Pei Tsai +6 more
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Heliyon, 2023 Introduction: There is still a lack of sensitive predictive tools for stroke outcomes. High galectin-3 concentration is associated with an increased risk of stroke.
Xiaoling Han +11 more
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The promigratory activity of the matricellular protein galectin-3 depends on the activation of PI-3 kinase. [PDF]
PLoS ONE, 2011 Expression of galectin-3 is associated with sarcoma progression, invasion and metastasis. Here we determined the role of extracellular galectin-3 on migration of sarcoma cells on laminin-111.
Fabiana H M Melo +7 more
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Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers [PDF]
, 2013 Background: Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx.
Argüeso, Pablo +7 more
core +7 more sources
Assessment of serum galectin-3 levels in acute rheumatic fever
The Turkish Journal of Pediatrics, 2022 Background. Galectin-3 is a biomarker which takes a role in both acute and chronic inflammation as well as fibrosis and oxidative stress. Increased levels of it are associated with cardiovascular diseases.
Serdar Epçaçan +3 more
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