Results 161 to 170 of about 54,078 (242)

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Transcriptomic and Proteomic Analyses Show Minimal Role for ST2 on MCPT5‐Expressing Mast Cells in Primary Heligmosomoides polygyrus bakeri Infection

Parasite Immunology, Volume 48, Issue 4, April 2026.
ABSTRACT The IL‐33/ST2 pathway is important as part of the type 2 immune response against helminth infections. Mast cells express the highest levels of the IL‐33 receptor subunit ST2 of any immune cell, and mast cells can mediate type 2 immune inflammation; however, the role of IL‐33‐driven mast cell responses in helminth infection is poorly understood.
Nicole W. P. Ong, Suzanne H. Hodge, Christa P. Baker, Danielle J. Smyth, Tania Frangova, Henry J. McSorley   +5 more
wiley   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

ST2 and Galectin-3: Ready for Prime Time?

EJIFCC, 2016
ST2 and galectin-3 are emerging biomarkers in the field of heart failure and have been extensively studied, and that whether they provide additional prognostic value on top of the clinical models and the gold standard in HF, (NT-pro)BNP. Our aim was to provide a comprehensive review of these emerging HF-related biomarkers in chronic, acute and incident
Meijers, Wouter C, van der Velde, A Rogier, de Boer, Rudolf A   +2 more
openaire   +2 more sources

Galectin-3 in AKI: Pathogenic Target, Diagnostic Biomarker, or Both? [PDF]

Int J Biol Sci
Gui Y, Zhou D.
europepmc   +1 more source

Galectin-3 and Cardio-Kidney Outcomes: A Bit of History Repeating. [PDF]

Kidney Med
Dobre M.
europepmc   +1 more source

The Role of Galectin-3 in Liver Inflammation and Fibrosis. [PDF]

J Inflamm Res
Lurje I, Biegel DK, Zhang IW, Tacke F.
europepmc   +1 more source

Galectin-3 in the Lateral Ventricle Regulates Immune Functions. [PDF]

ASN Neuro
Soares LC, Bernhardova H, Szele FG.
europepmc   +1 more source

Wash, Rinse, Repeat: Moving Galectin-3 From Research to Clinical Practice. [PDF]

Kidney Med
Banerjee S, Wettersten N.
europepmc   +1 more source

Glycoengineering CAR-T cells to overcome galectin-3-mediated immunosuppression. [PDF]

Front Immunol
Lau LS, Suarez M, Fernandez B, Souchak J, Antonopoulos A, Hu N, Abreu MM, Koehne G, Dell A, Haslam SM, Posey AD, Dimitroff CJ.   +11 more
europepmc   +1 more source