Results 171 to 180 of about 93,278,916 (238)

Higher Cardiorespiratory Fitness Is Associated With a Lower Burden of Metabolic Syndrome Traits: A Cross‐Sectional Analysis of 39 197 UK Adults

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11608-11620, December 2026.
ABSTRACT Aims To investigate associations of cardiorespiratory fitness (CRF) with metabolic syndrome (MetS) trait count, MetS prevalence and individual MetS traits in a large population‐based cohort. Materials and Methods This cross‐sectional study analysed data for 39 197 adults from a UK‐based independent healthcare charity (mean ± SD: age, 45.8 ± 9 ...
Scott A. Willis, Annalena Phillipp, Kevin Deighton, Christopher Goodwin, Daniel J. Cuthbertson, Shelley E. Keating, Christopher J. A. Pugh, Jonathan G. Stine, Gaël Ennequin, Alexis Couret, David J. Stensel, Guruprasad P. Aithal, Thomas Yates, James A. King   +13 more
wiley   +1 more source

Liver Injury Due to Hormonal Contraceptives in the Modern Era

Liver International, Volume 46, Issue 12, December 2026.
ABSTRACT Background and Aims Hormonal agents and their association with liver injury remain a concern in clinical practice. This study aimed to characterise the biochemical and clinical features of hormonal agent‐associated liver injury and compare them with a control group of age‐ and gender‐matched cases of liver injury caused by non‐hormonal drugs ...
Raj Vuppalanchi, A. Sidney Barritt, Anjali Rai, Huiman Barnhardt, Sherry Gu, Yi‐Ju Li, Naga Chalasani, for the Drug‐Induced Liver Injury Network, Naga Chalasani, Marwan Ghabril, Raj Vuppalanchi, Bob Fontana, Alisa Likhitsup, Vincent Chen, Victoria Shakhin, Paul Watkins, Sid Barritt, B. B. Behera, Jacquee Simpson, Herb Bonkovsky, Dee Faust, Andrew Stolz, Lily Dara, Neil Kaplowitz, Susan Milstein, Gina Choi, Jacqueline Nguyen, Angela Yeh, Dina Halegoua‐DeMarzio, Victor Navarro, Manish Thapar, Manisha Verma, Katrin Koy‐Pan, Verma Manisha, Cynthia Miller, Angela Pallotto, Christopher Koh, Beverly Niles, Jaha Norman, Huiman Barnhart, Matthew Baum, Jiezhun Gu, Yi‐Ju Li, Michelle McClanahan‐Crowder, Jeremy Mercer, Patricia Montana, Viviana Moreno, Eilene Pham, Hoss Rostami, Sheri Ussery, Kaye Williams, Stephanie Wu, Peter Hoffmann, Kidney Diseases, José Serrano, Jay Hoofnagle, Averell H. Sherker   +56 more
wiley   +1 more source

Shikonin: From Biosynthesis and Pharmacological Mechanisms to Translational Safety and Drug Delivery

ChemBioChem, Volume 27, Issue 21, 12 November 2026.
Shikonin, biosynthesised in Boraginaceae roots from phenylalanine‐derived PHB and isoprenoid GPP, modulates redox balance, cellular stress, signalling pathways, and regulated cell death. Preclinical studies support diverse pharmacological activities, while nanocarriers improve dispersion and delivery.
Namini Joshi, Prabhakar Semwal, Balwant Rawat, Ravendra Kumar, Mozaniel Santana de Oliveira, Nishant Rai, Janhvi Mishra Rawat   +6 more
wiley   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Push–pull hypothesis of Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 11, November 2026.
Abstract The “push–pull” hypothesis of Alzheimer's disease (AD) emerges from a careful examination of the key discoveries over the past 40 years. Specifically, amyloid beta (Aβ) plays a direct role impairing endolysosome activity in neurons and microglia, promoting the collapse of proteostasis, reducing tau degradation, and facilitating the cell‐to ...
Matthew Townsend
wiley   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2280-2291, November 2026.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Ventricular and Choroid Plexus Morphological Alterations and Their Associations With Peripheral Biomarkers in Behavioral Variant Frontotemporal Dementia

Brain and Behavior, Volume 16, Issue 11, November 2026.
ABSTRACT Background Frontotemporal dementia (FTD) is a neurodegenerative disorder and a major cause of early‐onset dementia. Alterations in ventricular and choroid plexus volumes have been reported in several neurodegenerative diseases. The morphological alterations of the ventricular system and choroid plexus in behavioral variant frontotemporal ...
Ailing Yue, Qianqian He, Hua Lu, Yufei Chen, Jiahui Hou, Yuxuan Xu, Liyong Wu, Min Chu   +7 more
wiley   +1 more source

Mechanistic Study of GSDME and CXCL10 in SUV39H1‐Mediated Pyroptosis and Immune Suppression in Cervical Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Cervical cancer (CC) remains a major global health challenge characterized by high incidence and mortality. The histone methyltransferase suppressor of variegation 3–9 homolog 1 (SUV39H1) has emerged as a key epigenetic regulator in tumor progression, but its role in modulating pyroptosis and remodeling of the immune microenvironment in CC ...
Li Zhang, Peiting Sheng, Dongge Cai, Ziyue Zhao, Xiaoling Wu, Yan'e Gao   +5 more
wiley   +1 more source

Galectin‐3 and Hypertensive Heart Disease

The Journal of Clinical Hypertension, 2015
CUSPIDI, CESARE, Tadic, M, Sala, C.
openaire   +5 more sources

Compressive Goiter Hiding Clear Cell Renal Cell Carcinoma Metastases to the Thyroid Gland—Report of a Rare Case and Literature Review

Clinical Case Reports, Volume 14, Issue 11, November 2026.
Histological section (hematoxylin and eosin, 40× magnification) of the total thyroidectomy specimen showing the presence of characteristic compact nests and cellular sheets with clear or eosinophilic cytoplasm, diagnostic for secondary involvement of the thyroid gland by clear cell renal cell carcinoma.
Chuyao Ying, Henrique Messias, Carlos Zagalo, Saudade André, Pedro Gomes   +4 more
wiley   +1 more source