Results 161 to 170 of about 93,278,916 (238)

Galectin-3 and phagocyte function in asthma

open access: yes
Asthma is a chronic obstructive airway condition that is thought to affect 300 million people globally including around 2.5 million Australians. Asthma-related expenditure in Australia alone is estimated to be over $600 million dollars annually, half of ...
Melanie Erriah (6173654)
core  

An Orally Available Halothiazole Glycomimetic as a Cancer-Targeting Dual Galectin-1 and Galectin-3 Inhibitor

open access: yes
Inhibition of several of the 10 hallmarks of cancer (Hanahan and Weinberg) would result in a broader and more durable treatment compared to current single or combination drug treatments.
Wachenfeldt, Henrik von   +26 more
core   +1 more source

Understanding exosomes in regenerative dentistry

open access: yesPeriodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad   +2 more
wiley   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

open access: yesPeriodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon   +6 more
wiley   +1 more source

A new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk‐factor modification in atrial fibrillation

open access: yesExperimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) prevalence rises sharply with age due to two independent mechanisms. Ageing produces irreversible arrhythmogenic substrate changes through progressive fibrosis, cellular senescence and mitochondrial dysfunction, while modifiable risk factors such as obesity, hypertension, sleep apnoea, diabetes and alcohol use promote ...
Udit Thakur, Jonathan M. Kalman
wiley   +1 more source

Galectin-3: clinical utility and prognostic value in patients with heart failure

open access: yes, 2013
Frank KramerClinical Sciences, Global Biomarker Strategy and Development, Bayer HealthCare, Wuppertal, GermanyAbstract: This review summarizes the key findings of 14 clinical trials in which Galectin-3 was assessed as a biomarker of heart failure.
Kramer F
core  

Galectin‐3 plasma levels are associated with left atrial contractile function in long‐distance runners

open access: yesExperimental Physiology, EarlyView.
Abstract High‐intensity endurance exercise induces myocardial remodelling as an adaptive response to sustained volume overload, but excessive cumulative training might also favour deleterious cardiac remodelling, including atrial fibrosis. Whether acute marathon running engages circulating fibrosis‐related biomarkers and whether these biomarkers track ...
Felipe Contreras‐Briceño   +6 more
wiley   +1 more source

Nanobiomechanics in Oncology: Atomic Force Microscopy for Cancer Mechanophenotyping Using Cellular Young's Modulus

open access: yesJournal of the Royal Society of New Zealand, Volume 57, Issue 1, February 2027.
This review examines the current literature on the application of atomic force microscopy (AFM) to cancer mechanophenotyping, with particular emphasis on cellular Young's modulus and its potential diagnostic significance. A structured electronic search of PubMed, Scopus and Google Scholar was conducted to identify studies published between 1999 and ...
Hermawan Tjoa   +4 more
wiley   +1 more source

sox17 Mutagenesis Reveals Compounding Effects ofMaternal and Zygotic Contribution on Microglia Abundance

open access: yesGlia, Volume 75, Issue 1, January 2027.
sox17 is a maternal effect gene impacting microglia and microglia precursor abundance. sox17 mRNA injection timed to maternal contribution rescues abundance. A CRISPR screen reveals f11r.1, gas6, and mpp1 also regulate microglia abundance. ABSTRACT Embryonic development is shaped by maternal and zygotic factors but how the interplay between these ...
Camden A. Spring   +4 more
wiley   +1 more source

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