Results 181 to 190 of about 93,278,916 (238)

Right Ventricular Dysfunction and Ventriculo‐Arterial Uncoupling in Heart Failure With Preserved Ejection Fraction: A Phenotype‐Specific Review of Mechanisms, Diagnosis, and Therapeutic Strategies

Clinical Cardiology, Volume 49, Issue 11, November 2026.
Right ventricular dysfunction affects 19%–33% of patients With heart failure With preserved ejection fraction and is associated With exercise intolerance, hospitalization, and mortality. Assessing right ventricular function and its coupling with the pulmonary circulation may improve risk stratification and support management tailored to distinct ...
Amarelle Chamoun, Talha Farooq, Suhayya Batool, Sadia Tameez‐ud—din, Muhammad Yousaf, Preet Memon, Mohsin Ali, Arun Kumar Maloth, F. N. U. Sawaira, Muhammad Taimur Khan, Mohammad Eisa Ali, Mansoor Khalid, Maleeha Pandit, Kamil Ahmad Kamil   +13 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Site‐specific O‐glycans influence lacritin structure and multimerization in tears

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Lacritin is an abundantly expressed glycoprotein in tear fluid and plays key roles in immune response, tear secretion, and bacterial killing. These biological functions are tightly regulated through several biochemical mechanisms including multimerization, proteolysis, and alternative splicing, especially within its C‐terminal domain.
Vincent Chang, Ryan J. Chen, Isaac Lian, Madilynn Hamilton, Keira E. Mahoney, Jeff Romano, Gordon Laurie, Stacy A. Malaker   +7 more
wiley   +1 more source

Exercise‐Based Management of Diabetic Cardiomyopathy: Preclinical Mechanisms, Clinical Evidence, and Translational Strategies

Journal of Diabetes, Volume 18, Issue 11, November 2026.
Exercise may mitigate diabetic cardiomyopathy by improving mitochondrial metabolism, redox balance, calcium handling, and inflammatory‐fibrotic remodeling. Translation into clinical practice requires phenotype‐ and risk‐adapted exercise prescriptions, standardized dose reporting, and multimodal monitoring to define safety, efficacy, and long‐term ...
Xiaoya Li, Zhiqiang Wang, Jingjing Liu
wiley   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, Volume 117, Issue 11, Page 2967-2981, November 2026.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, Volume 104, Issue 10, Page 996-1014, November‐December 2026.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Galectin-3 and galectin-3 binding protein in rheumatoid arthritis

, 2003
Ohshima, S, Kuchen, S, Seemayer, C, Liu, FT, Neidhart, M, Gay, RE, Gay, S   +6 more
openaire   +1 more source

Encoding Cell‐Surface Receptor Function Through Glycosylation: Lessons From CD44

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
CD44 function is not solely determined by its protein sequence, it is dynamically encoded by its glycosylation state. Glycan remodeling generates distinct functional receptor states that regulate ligand recognition, receptor organization, lectin interactions, and signaling.
María Payá‐García, José Manuel Rojas‐Marcos, Iris A. Bermejo, Diego Del Balzo, Ana Ardá, Luca Unione, Jesús Jiménez‐Barbero, Ana Gimeno   +7 more
wiley   +1 more source