Results 181 to 190 of about 18,236,146 (293)

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

open access: yesAdvanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Moringa oleifera Lam. Seed Lectin (WSMoL) Attenuates Parkinsonian Symptoms in Mice via Anti‐Inflammatory, Antioxidant, and Neurotransmitter‐Modulating Effects

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
WSMoL attenuates motor impairment, neuroinflammation, oxidative stress, and monoamine depletion in a rotenone‐induced model of Parkinson's disease. The involvement of D1 receptor‐mediated signaling is demonstrated, providing new insights into the mechanisms underlying its neuroprotective effects and supporting WSMoL as a promising candidate for further
Leydianne Leite de Siqueira Patriota   +14 more
wiley   +1 more source

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single‐cell and bulk transcriptomic analysis

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative single‐cell and bulk transcriptomic analyses identified a highly inflammatory macrophage state and a vascular smooth muscle cell (VSMC) remodeling continuum in human atherosclerotic plaques. Candidate ligand‐receptor and ligand‐associated target gene expression patterns linked inflammatory macrophage activation with osteogenic/modulated ...
Xinyu Dong   +8 more
wiley   +1 more source

Predictive value of Galectin-3 in cognitive impairment: a systematic review and meta-analysis. [PDF]

open access: yesFront Neurol
Yang YY   +7 more
europepmc   +1 more source

In Vitro Activity of Citrus IntegroPectin Against Breast Cancer and Colon Cancer

open access: yesChemFoodChem, Volume 2, Issue 3, September 2026.
Image shows microscopic photographs of MCF‐7 cells in the presence of lemon, red orange, and sweet orange IntegroPectin bioconjugates at 0.5 or 1.0 mg/mL concentration after 24 h next to a photograph of MCF‐7 cells as such (control). ABSTRACT We investigate the ability of IntegroPectin bioconjugates obtained via acoustic cavitation of lemon, red orange,
Claudia D'Anna   +5 more
wiley   +1 more source

The C‐Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus

open access: yesEuropean Journal of Immunology, Volume 56, Issue 9, September 2026.
Whether viral lipids can directly interact with pattern recognition receptors to modulate antiviral immune responses remains unclear. We show that Mincle‐dependent recognition of HCMV viral particles induces proinflammatory cytokine production in primary human macrophages.
Vladimir Bokun   +6 more
wiley   +1 more source

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