Results 171 to 180 of about 53,821 (254)

Galectin-3 exacerbates autoimmune diabetes by limiting regulatory T cell differentiation and function. [PDF]

Sci Adv
Xie L, Zhang R, Zou H, Hu J, Deng J, Ding J, Liu L, Lin Q, Zhao B, Xu A, Zhou Z, Xiao Y.   +11 more
europepmc   +1 more source

Fluorophore Modulates Intracellular Distribution of Enzyme‐Instructed Self‐Assembly of Short Peptides in Osteosarcoma Cells

Small Methods, Volume 10, Issue 3, 9 February 2026.
Fluorophores at the peptide C‐terminus reprogram EISA behavior in osteosarcoma cellsshifting ER vs mitochondrial targeting, altering assembly, and tuning cytotoxicity. Abstract Enzyme‐instructed self‐assembly (EISA) of peptides offers a versatile strategy for developing intracellular nanomedicines, yet the role of C‐terminus fluorophores in modulating ...
Yali Huang, Meihui Yi, Yuchen Qiao, Bing Xu   +3 more
wiley   +1 more source

Galectin-3 is dispensable for thoracic aortic aneurysmal formation and rupture in mice. [PDF]

JVS Vasc Sci
Ramesh N, Downey E, Kanumuri SK, Liu Z, Subramanian V.   +4 more
europepmc   +1 more source

Potential clinical utility of small extracellular vesicles derived from head and neck tumours

VIEW, Volume 7, Issue 1, February 2026.
Small extracellular vesicles (EVs) carry selective protein cargoes that reflect tumour cell status, making them valuable for biomarker discovery. This study compared EV proteomes from head and neck cancer (HNC) tumour tissue, saliva and plasma. Over 60% of proteins were shared across all sources, with enrichment in cancer‐related pathways such as ...
Abolfazl Jangholi, B. W. M. Thilini J. Basnayake, Omar Breik, Lizbeth Kenny, Sarju Vasani, Riccardo Dolcetti, Chamindie Punyadeera   +6 more
wiley   +1 more source

The importance of Galectin-3 in the diagnosis of childhood acute appendicitis. [PDF]

Turk J Med Sci
Yalçin O, Kalyoncu Ayçenk A, Aygün A, Gürpinar AB, Saribaş MS, Altinok V, Noyan T.   +6 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4/NF‐κB/IL‐6/STAT3 Signalling Cascade

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT High mobility group box 1 (HMGB1), a prototypical alarmin and chromatin‐binding protein, has emerged as a critical mediator of tumour‐associated inflammation and immune regulation. Although its soluble form has been implicated in various malignancies, the functional contribution of HMGB1 encapsulated within exosomes remains incompletely ...
Jia‐Ru Huang, Wen‐Chao Gu, Ya‐Ping Yuan, Jun‐Xia Yang, Yan Chen, Xiao‐Xia Guo, Wei Ding   +6 more
wiley   +1 more source

Sirt6 deficiency in mast cells promotes adipose fibroinflammation in obesity through galectin-3 signaling. [PDF]

Nat Commun
Song MY, Jeon YG, Do Yang J, Moon YJ, Kim JB, Bae EJ, Park BH.   +6 more
europepmc   +1 more source

Evaluation of the effectiveness and safety of ONO‐2910 for the treatment of diabetic polyneuropathy: An early Phase IIa, multicenter, randomized, placebo‐controlled, double‐blind study in Japanese patients

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 310-320, February 2026.
ABSTRACT Aims/Introduction Diabetic polyneuropathy (DPN) is common in patients with diabetes. Its symptoms include pain, numbness, and impaired neurosensory function. ONO‐2910 promotes Schwann cell differentiation and is being developed for DPN. Materials and Methods This Phase IIa randomized controlled trial evaluated the effectiveness and safety of ...
Yukiko Onishi, Takeshi Osonoi, Norio Takahashi, Toru Takiguchi, Eiichiro Morishima, Yoshimasa Aso, Kenji Sekiguchi, Hideki Kamiya, Jiro Nakamura   +8 more
wiley   +1 more source

The diagnostic efficacy of serum galectin-3 and other markers in papillary thyroid carcinoma. [PDF]

Gland Surg
Zhang X, Song X, Li Y, Liu X.
europepmc   +1 more source