Results 41 to 50 of about 53,821 (254)

Circulating neuregulin-1 and galectin-3 can be prognostic markers in breast cancer [PDF]

, 2017
Background: It is important to identify novel plasmatic biomarkers that can contribute to assessing the prognosis and outcome of breast cancer patients.
Cardelli, Patrizia, DE IULIIS, Francesca, Lanza, Rosina, Salerno, Gerardo, Scarpa, Susanna, Taglieri, Ludovica   +5 more
core   +1 more source

Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease [PDF]

, 2018
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here, we have investigated the role of peripheral inflammation induced by systemic lipopolysaccharide (LPS) administration in the MPTP-based model of Parkinson’s ...
Carrillo Jiménez, Alejandro, García Domínguez, Irene, García Revilla, Juan, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Santiago Pavón, Martiniano, Venero Recio, José Luis, Veselá, Karolina   +7 more
core   +3 more sources

Galectin-3 Binding and Metastasis [PDF]

, 2003
Galectin-3 (gal-3) is a member of a growing family of carbohydrate-binding proteins. It consists of two functional domains: an amino-(N)-terminal domain, which is cleavable by collagenases and is responsible for dimerization as well as secretion of the protein, and a carboxy-(C)-terminal domain with affinity for carbohydrates containing N ...
Pratima, Nangia-Makker, Vitaly, Balan, Avraham, Raz   +2 more
openaire   +3 more sources

Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3

Bioengineering, 2017
Galectin inhibitor design is an emerging research field due to the involvement of galectins in cancer. Galectin-3, in particular, plays an important role in tumor progression.
Sophia Böcker, Lothar Elling
doaj   +1 more source

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells [PDF]

, 2017
Epidermal growth factor receptor (EGFR) is an important regulator of epithelial cell growth and survival in normal and cancerous tissues and is a principal therapeutic target for cancer treatment.
A Kharbanda, AC Midgley, Anisha R Chacko, AU Newlaczyl, BG Bitler, BJ Engel, BJ Engel, BT Blakely, D Neeraja, DE Swinson, DW Kufe, EE Er, F Guddo, F Montemurro, FT Liu, H Barrow, HY Kuo, I Iurisci, IC Gaemers, J Hilkens, J Mendelsohn, J Merlin, J Rubin Grandis, J Taylor-Papadimitriou, J Wesseling, JA Schroeder, JC Byrd, John Hilkens, Jonathan M Rhodes, JP Dawson, JY Fang, K Kato, KL Pierce, L Haddon, LG Yu, LG Yu, Lu-Gang Yu, M Alam, MR Pochampalli, N Normanno, NE Hynes, NJ Bessman, Paulina Sindrewicz, PK Singh, Q Zhao, Q Zhao, R Ahmad, RE Beatson, S Bafna, S Ramasamy, S Song, Tushar Piyush, X Wei, Y Mori, Y Umekita   +54 more
core   +1 more source

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Angewandte Chemie, EarlyView.
Electrostatically layered nanoparticles (NPs) coated with anionic polypeptides selectively target cancer cells by engaging amino acid transporters. Poly(L‐glutamate) (PLE) coatings cluster the glutamine transporter SLC1A5, prolonging NP surface retention, while poly(L‐aspartate) (PLD) coatings also bind SLC1A3, potentially promoting faster ...
Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond   +10 more
wiley   +2 more sources

The Expression of Galectin-3 in Tumor and Cancer-Associated Fibroblasts in Invasive Micropapillary Breast Carcinomas: Relationship with Clinicopathologic Parameters

European Journal of Breast Health, 2021
Objective:Galectin-3 affects tumor progression and cell surface polarization by expressing from the tumor and cancer-associated fibroblasts (CAFs). Therefore, it may have a role on micropapillary carcinomas (IMPC), which have characteristic morphological
Yasemin Çakır, Canan Kelten Talu, Özlem Mermut, Didem Can Trabulus, Esra Arslan   +4 more
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Galectin-3 determines tumor cell adaptive strategies in stressed tumor microenvironments

Frontiers in Oncology, 2016
Galectin-3 is a member of the b-galactoside binding lectin family, whose expression is often dysregulated in cancers. While galectin-3 is usually an intracellular protein, found in the nucleus and in the cytoplasm; under certain conditions, galectin-3 ...
Ana Carolina Ferreira Cardoso, Luciana Nogueira de Sousa Andrade, Silvina Odete Bustos, Roger eChammas   +3 more
doaj   +1 more source

Characterization of peptides and phage that bind galectin-3 selected from bacteriophage display libraries: a study of the role of galectin-3 in metastasis-associated cancer cell adhesion [PDF]

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Zou, Jun, 1970-
core   +1 more source