Results 41 to 50 of about 54,078 (242)

Galectin-3 Binding and Metastasis [PDF]

, 2003
Galectin-3 (gal-3) is a member of a growing family of carbohydrate-binding proteins. It consists of two functional domains: an amino-(N)-terminal domain, which is cleavable by collagenases and is responsible for dimerization as well as secretion of the protein, and a carboxy-(C)-terminal domain with affinity for carbohydrates containing N ...
Pratima, Nangia-Makker, Vitaly, Balan, Avraham, Raz   +2 more
openaire   +3 more sources

Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

PLoS ONE, 2013
Multidrug resistance (MDR), an unfavorable factor compromising the treatment efficacy of anticancer drugs, involves the upregulation of ATP binding cassette (ABC) transporters and induction of galectin-3 signaling. Galectin-3 plays an anti-apoptotic role
Yung-Kuo Lee, Tsung-Hsien Lin, Chuan-Fa Chang, Yu-Li Lo   +3 more
doaj   +1 more source

Biotinylated N-Acetyllactosamine- and N,N-Diacetyllactosamine-Based Oligosaccharides as Novel Ligands for Human Galectin-3

Bioengineering, 2017
Galectin inhibitor design is an emerging research field due to the involvement of galectins in cancer. Galectin-3, in particular, plays an important role in tumor progression.
Sophia Böcker, Lothar Elling
doaj   +1 more source

The Expression of Galectin-3 in Tumor and Cancer-Associated Fibroblasts in Invasive Micropapillary Breast Carcinomas: Relationship with Clinicopathologic Parameters

European Journal of Breast Health, 2021
Objective:Galectin-3 affects tumor progression and cell surface polarization by expressing from the tumor and cancer-associated fibroblasts (CAFs). Therefore, it may have a role on micropapillary carcinomas (IMPC), which have characteristic morphological
Yasemin Çakır, Canan Kelten Talu, Özlem Mermut, Didem Can Trabulus, Esra Arslan   +4 more
doaj   +1 more source

Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]

, 2005
Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines, Ilarregui, Juan Martin, Rabinovich, Gabriel Adrián, Rubinstein, Natalia, Sanjuan, Norberto Aníbal, Toscano, Marta Alicia   +5 more
core   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Could Galectin 3 Be a Good Prognostic Factor in Endometrial Cancer?

Diagnostics, 2020
Galectin 3 is a modulator of several basic biological functions. It may be involved in the development of obesity and type 2 diabetes—risk factors of endometrial cancer.
Aneta Cymbaluk-Płoska, Paula Gargulińska, Sebastian Kwiatkowski, Ewa Pius-Sadowska, Bogusław Machaliński   +4 more
doaj   +1 more source

Characterization of peptides and phage that bind galectin-3 selected from bacteriophage display libraries: a study of the role of galectin-3 in metastasis-associated cancer cell adhesion [PDF]

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Zou, Jun, 1970-
core   +1 more source

Interaction of galectin-3 with MUC1 on cell surface promotes EGFR dimerization and activation in human epithelial cancer cells [PDF]

, 2017
Epidermal growth factor receptor (EGFR) is an important regulator of epithelial cell growth and survival in normal and cancerous tissues and is a principal therapeutic target for cancer treatment.
A Kharbanda, AC Midgley, Anisha R Chacko, AU Newlaczyl, BG Bitler, BJ Engel, BJ Engel, BT Blakely, D Neeraja, DE Swinson, DW Kufe, EE Er, F Guddo, F Montemurro, FT Liu, H Barrow, HY Kuo, I Iurisci, IC Gaemers, J Hilkens, J Mendelsohn, J Merlin, J Rubin Grandis, J Taylor-Papadimitriou, J Wesseling, JA Schroeder, JC Byrd, John Hilkens, Jonathan M Rhodes, JP Dawson, JY Fang, K Kato, KL Pierce, L Haddon, LG Yu, LG Yu, Lu-Gang Yu, M Alam, MR Pochampalli, N Normanno, NE Hynes, NJ Bessman, Paulina Sindrewicz, PK Singh, Q Zhao, Q Zhao, R Ahmad, RE Beatson, S Bafna, S Ramasamy, S Song, Tushar Piyush, X Wei, Y Mori, Y Umekita   +54 more
core   +1 more source

The role of galectin-3 and galectin-3–binding protein in venous thrombosis [PDF]

Blood, 2015
Key PointsWe determined the location of gal3bp and gal3 and their role in promoting VT and leukocyte/endothelial cell interactions for the first time. Gal3bp and gal3 have the potential to be used as targets for future VT therapies.
Elise P, DeRoo, Shirley K, Wrobleski, Evelyn M, Shea, Ramsey K, Al-Khalil, Angela E, Hawley, Peter K, Henke, Daniel D, Myers, Thomas W, Wakefield, Jose A, Diaz   +8 more
openaire   +2 more sources