Results 61 to 70 of about 18,236,146 (293)
Could Galectin 3 Be a Good Prognostic Factor in Endometrial Cancer?
Diagnostics, 2020 Galectin 3 is a modulator of several basic biological functions. It may be involved in the development of obesity and type 2 diabetes—risk factors of endometrial cancer.
Aneta Cymbaluk-Płoska +4 more
doaj +1 more source
Advanced Science, EarlyView.Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin +20 more
wiley +1 more source
Galectin-3 determines tumor cell adaptive strategies in stressed tumor microenvironments
Frontiers in Oncology, 2016 Galectin-3 is a member of the b-galactoside binding lectin family, whose expression is often dysregulated in cancers. While galectin-3 is usually an intracellular protein, found in the nucleus and in the cytoplasm; under certain conditions, galectin-3 ...
Ana Carolina Ferreira Cardoso +3 more
doaj +1 more source
Advanced Science, EarlyView.A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao +15 more
wiley +1 more source
Targeting galectin-3 in cancer by novel and unique inhibitors of non-carbohydrate origin
Molecular MedicineThe galactoside-binding galectin-3 is a multi-mode promoter in a broad range of cancers, as well as in the pathogenesis of inflammation and fibrosis-associated diseases. It is currently a hotly pursued therapeutic target in those disease areas.
Paulina Sindrewicz-Goral +8 more
doaj +1 more source
Cells, 2019 Galectin-3 regulates numerous biological processes in the gut. We investigated molecular mechanisms responsible for the Galectin-3-dependent regulation of colon inflammation and evaluated whether Galectin-3 may be used as biomarker for monitoring the ...
Vladislav Volarevic +7 more
doaj +1 more source
Galectin-3 promotes EV71 infection.
, 2016 (A) Using TALEN, ablation of the galectin-3 gene was performed in RD cells. Two clones of galectin-3 knock-out (G3KO) RD cells were selected. Protein expression of galectin-3 was examined in cell lysates from RD cells and two G3KO clones (G3KO-A1 and ...
Yungling Lee (3454598) +7 more
core +1 more source
Advanced Science, EarlyView.A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu +10 more
wiley +1 more source
, 2011 Background: A growing body of evidence links macrophage activation and fibrosis to the pathogenesis of heart failure (HF). Galectin-3 is one of the most likely mediators between macrophage activation and myocardial fibrosis.
LIN, YEN-HUNG;LIN, LIAN-YU;WU, YEN-WEN;CHIEN, KUO-LIONG;LEE, CHII-MING;HSU, RON-BIN;CHAO, CHIA-LUN;WANG, SHOEI-SHEN;HSEIN, YENH-CHEN;LIAO, LIN-CHU;HO, YI-LWUN;CHEN, MING-FONG +1 more
core +1 more source
Increased Adiposity, Dysregulated Glucose Metabolism and Systemic Inflammation in Galectin-3 KO Mice [PDF]
, 2013 PMCID: PMC3579848This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Karla J. Castellanos (7918193) +35 more
core +1 more source