Results 61 to 70 of about 93,278,916 (238)

Galectin-3 Gene (Lgals3) +292c Allele Is a Genetic Predisposition Factor for Rheumatoid Arthritis in Taiwan

, 2012
Galectin-3 is a beta-galactoside-binding lectin which is involved in modulating inflammation and apoptosis. Elevated expression of galectin-3 has been demonstrated in synovium of rheumatoid arthritis (RA).
HU, CHUNG-YI;CHANG, SHENG-KAI;WU, CHIEN-SHENG;TSAI, WEI-I;HSU, PING-NING, 胡忠怡;張勝凱;吳建陞;蔡瑋儀;許秉寧   +1 more
core   +1 more source

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Diagnostic value of tear Galectin-1 and Galectin-3 in keratoconus: a prospective case-control study

BMC Ophthalmology
Background This study aims to evaluate tear Galectin-1 and Galectin-3 levels in patients with keratoconus and healthy controls, assess their diagnostic performance, and investigate their associations with corneal tomography parameters.
Ali Kosekahya, Pinar Kosekahya, Huseyin Bugra Turk, Gamze Avcioglu, Özcan Erel, Aysen Erdem   +5 more
doaj   +1 more source

The Expression of Galectin-3 in Tumor and Cancer-Associated Fibroblasts in Invasive Micropapillary Breast Carcinomas: Relationship with Clinicopathologic Parameters

European Journal of Breast Health, 2021
Objective:Galectin-3 affects tumor progression and cell surface polarization by expressing from the tumor and cancer-associated fibroblasts (CAFs). Therefore, it may have a role on micropapillary carcinomas (IMPC), which have characteristic morphological
Yasemin Çakır, Canan Kelten Talu, Özlem Mermut, Didem Can Trabulus, Esra Arslan   +4 more
doaj   +1 more source

Placental galectin-3 is reduced in early-onset preeclampsia

, 2022
Preeclampsia is a disease of pregnancy responsible for significant maternal and neonatal mortality. Galectin-3 is a β-Galactoside binding protein. This study aimed to characterise galectin-3 in women with preeclampsia and human trophoblast stem cells ...
Kandel, Manju, Bartho, Lucy A, Walker, Susan P, Nguyen, Tuong-Vi, Tong, Stephen, MacDonald, TM, Hannan, Natalie J, Kaitu'u-Lino, Tu'uhevaha J, Cannon, Ping, Kaitu’u-Lino, Tu’uhevaha J., Bartho, LA, Cannon, P, Hannan, Natalie J., Walker, SP, Kandel, M, Tong, S, Hannan, NJ, MacDonald, Teresa M., Nguyen, TV, Kaitu’u-Lino, TJ, MacDonald, Teresa M   +20 more
core   +1 more source

Mac‐2 Binding Protein Glycosylation Isomer (M2BPGi)–Based Risk Stratification Refined by Tumor Metabolic Activity in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe, Junya Mita, Shinji Itoh, Takeo Toshima, Yoshiyuki Kitamura, Norifumi Iseda, Takuro Isoda, Kousei Ishigami, Tomoharu Yoshizumi   +8 more
wiley   +1 more source

Galectins-1 and-3 Increase in Equine Post-traumatic Osteoarthritis

Frontiers in Veterinary Science, 2018
Galectins are potent regulators of cell adhesion, growth and apoptosis in diverse cell types, including chondrocytes and synovial fibroblasts. Elevations in synovial fluid galectin-3 have been observed in rheumatoid arthritis, juvenile idiopathic ...
Heidi L. Reesink, Alan J. Nixon, Jin Su, Sherry Liu, Ryan M. Sutton, Sabine Mann, Ashlee E. Watts, Ryan P. Peterson   +7 more
doaj   +1 more source

Galectin-3 promotes EV71 infection.

, 2016
(A) Using TALEN, ablation of the galectin-3 gene was performed in RD cells. Two clones of galectin-3 knock-out (G3KO) RD cells were selected. Protein expression of galectin-3 was examined in cell lysates from RD cells and two G3KO clones (G3KO-A1 and ...
Yungling Lee (3454598), Fu-Tong Liu (30764), Li-Min Huang (185153), Wen-Chan Huang (3597764), Hung-Lin Chen (172758), Kuan-Po Peng (3597767), Huan-Yuan Chen (3597761), Luan-Yin Chang (185145)   +7 more
core   +1 more source

Metastasis Pattern‐Specific Biomarkers and Therapeutic Targets in Gastric Cancer: From Surgical Specimens to Clinical Translation

Annals of Gastroenterological Surgery, EarlyView.
Gastric cancer metastasis should be considered according to its anatomical route, because lymphatic, peritoneal, and hematogenous dissemination involve partly distinct molecular mechanisms. This review summarizes metastasis pattern‐associated and pattern‐specific molecules identified using surgical specimens, evaluates their evidence and translational ...
Mitsuro Kanda
wiley   +1 more source