Results 71 to 80 of about 93,278,916 (238)

Galectin-3 and TREM2: a myeloid axis as a predictive biomarker for immune checkpoint inhibitors in cancer

Frontiers in Immunology
The ligand-receptor relationship between Galectin-3 and TREM2 has been identified in lung cancer. High expression of both is associated with anti-PD-1 efficacy, suggesting that the combination of both may predict the benefit of immune checkpoint ...
Runze Zhang, Junyang Pan, Junyang Pan, Nan Ma, Xiyang Tang, Jinbo Zhao   +5 more
doaj   +1 more source

Dynamics of galectin-3 in the nucleus and cytoplasm [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2010
This review summarizes selected studies on galectin-3 (Gal3) as an example of the dynamic behavior of a carbohydrate-binding protein in the cytoplasm and nucleus of cells. Within the 15-member galectin family of proteins, Gal3 (M(r) approximately 30,000) is the sole representative of the chimera subclass in which a proline- and glycine-rich NH(2 ...
Kevin C, Haudek, Kimberly J, Spronk, Patricia G, Voss, Ronald J, Patterson, John L, Wang, Eric J, Arnoys   +5 more
openaire   +2 more sources

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Serum apelin and galectin-3 in preeclampsia in Iraq

Hypertension in Pregnancy, 2020
Objective This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE).
Aamal Sattar Taha, Zohreh Zahraei, Hussein Kadhem Al-Hakeim   +2 more
doaj   +1 more source

Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice

Frontiers in Endocrinology, 2020
Aims/Hypothesis: Galectin 3 appears to play a proinflammatory role in several inflammatory and autoimmune diseases. Also, there is evidence that galectin 3 plays a role in both type-1 and type-2 diabetes.
Ivica Petrovic, Ivica Petrovic, Nada Pejnovic, Nada Pejnovic, Biljana Ljujic, Sladjana Pavlovic, Marina Miletic Kovacevic, Ilija Jeftic, Ilija Jeftic, Aleksandar Djukic, Nevena Draginic, Marijana Andjic, Nebojsa Arsenijevic, Miodrag L. Lukic, Nemanja Jovicic   +14 more
doaj   +1 more source

Galectin-3 recruitment to vacuoles containing translocon forming bacteria.

, 2022
HeLa cells expressing myc-Rac1Q61L and GFP-galectin-3 were infected with WA-314 YopD-ALFA at an MOI of 20 and incubated with NbALFA-580 diluted in cell culture medium. Cells were imaged with a spinning disk microscope recording z-stacks every minute. The
Maren Rudolph (11726318), Manuel Wolters (594572), Susanne Kulnik (12602366), Alexander Carsten (12602363), Martin Aepfelbacher (240477)   +4 more
core   +1 more source

Persistent Interleukin‐18 Fuels Expansion of CD38+HLA‐DR+CD8+ T Cells in Still Disease and Macrophage Activation Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease (SD) is an autoinflammatory disorder characterized by remarkably high interleukin‐18 (IL‐18) levels. Increasing evidence suggests that adaptive immunity also contributes to its pathogenesis, particularly in refractory courses. Macrophage activation syndrome (MAS), one of SD's most severe complications, is associated with further
Greta Rogani, Remco G. A. Erkens, Alejandra Bodelón, Tim R. Mocking, Marein T. M. Putmans, Freya M. C. H. Huijsmans, Lyanne J. P. M. Sijbers, Aafke M. De Ligt, Maurice J. H. Van Haaren, Rianne C. Scholman, Noël M. M. Dautzenberg, Joyce I. Meesters‐Ensing, Martina Rossano, Laura Porretti, Stefan Nierkens, Francesca S. Minoia, Sebastiaan J. Vastert, Jorg van Loosdregt   +17 more
wiley   +1 more source

The role of Galectin-3 in promoting metastasis of papillary thyroid carcinoma

Zhongguo aizheng zazhi, 2017
Background and purpose: Papillary thyroid cancer (PTC) is one of the most common carcinomas in humans. Galectin-3 is a multifunctional protein which regulates different process of tumorigenesis.
陆伟辉, 王　聪, 李　宸
doaj  

Time-course analysis of cardiac and serum galectin-3 in viral myocarditis after an encephalomyocarditis virus inoculation.

PLoS ONE, 2019
Galectin-3 is a β-galactoside-binding lectin which is important in cell proliferation and apoptotic regulation. Recently, serum galectin-3 has been shown to have prognostic value as a biomarker in heart failure.
Kei Noguchi, Hiroyuki Tomita, Tomohiro Kanayama, Ayumi Niwa, Yuichiro Hatano, Masato Hoshi, Shigeyuki Sugie, Hideshi Okada, Masayuki Niwa, Akira Hara   +9 more
doaj   +1 more source

Low translocon associated YopD-ALFA/YopD fluorescence signals in GFP-galectin-3 positive compartments.

, 2022
(A) NbALFA staining of translocon associated YopD-ALFA in fixed cells. HeLa cells expressing myc-Rac1Q61L and GFP-galectin-3 were infected with WA-314-YopD-ALFA at an MOI of 50 for 50 min.
Maren Rudolph (11726318), Manuel Wolters (594572), Susanne Kulnik (12602366), Alexander Carsten (12602363), Martin Aepfelbacher (240477)   +4 more
core   +1 more source