Results 91 to 100 of about 27,415 (188)

Galectin-3-binding protein: A multitask glycoprotein with innate immunity functions in viral and bacterial infections

Journal of Leukocyte Biology, 2018
AbstractGalectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ...
Loimaranta, Vuokko, Hepojoki, Jussi, Laaksoaho, Olli, Pulliainen, Arto T   +3 more
openaire   +4 more sources

MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3

BMC Cell Biology, 2001
Background Although MP20 is the second most highly expressed membrane protein in the lens its function remains an enigma. Putative functions for MP20 have recently been inferred from its assignment to the tetraspanin superfamily of integral membrane ...
Donaldson Paul J, Jacobs Marc D, Grey Angus C, Gonen Tamir, Kistler Joerg   +4 more
doaj   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source

Extracellular galectin-3 in tumor progression and metastasis

Frontiers in Oncology, 2014
Galectin-3, the only chimera galectin found in vertebrates, is one of the best-studied galectins. It is expressed in several cell types and is involved in a broad range of physiological and pathological processes, such as cell adhesion, cell activation ...
Anneliese eFortuna-Costa, Angélica Maciel Gomes, Eliene Oliveira Kozlowski, Mariana Paranhos Stelling, Mauro Sergio Pavao   +4 more
doaj   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Galectin-3 directs mitophagy in response to Parkin-/proteasome-dependent rupture of mitochondrial outer membrane

Biology Direct
PINK1/Parkin-dependent mitophagy is an intracellular process that selectively removes damaged, depolarized mitochondria. In this form of mitophagy, the mitochondrial outer membrane (OMM) undergoes focal rupture through a Parkin- and proteasome-dependent ...
Pei-Han Liu, Yu-Shan Lin, Wei-Hua Chu, Wei-Tse Sun, Po-Yu Huang, Jie-rong Huang, Wei-Chung Chiang   +6 more
doaj   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate

Nature Communications
Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N-glycans during such conformational transitions to ...
Massiullah Shafaq-Zadah, Estelle Dransart, Ilyes Hamitouche, Christian Wunder, Valérie Chambon, Cesar A. Valades-Cruz, Ludovic Leconte, Nirod Kumar Sarangi, Jack Robinson, Siau-Kun Bai, Raju Regmi, Aurélie Di Cicco, Agnès Hovasse, Richard Bartels, Ulf J. Nilsson, Sarah Cianférani-Sanglier, Hakon Leffler, Tia E. Keyes, Daniel Lévy, Stefan Raunser, Daniel Roderer, Ludger Johannes   +21 more
doaj   +1 more source