Results 21 to 30 of about 35,897 (197)

Galectinology of Equine Pregnancy

Animals, 2022
Galectins are a family of proteins that bind to glycans, acting in a cytokine-like manner throughout the body. In the majority of mammalians, galectins have been found to be involved in pregnancy maintenance, but few studies have evaluated this in the ...
Carleigh E. Fedorka, Hossam El-Sheikh Ali, Mats H. T. Troedsson   +2 more
doaj   +1 more source

Galectins and Gliomas [PDF]

Brain Pathology, 2009
AbstractMalignant gliomas, especially glioblastomas, are associated with a dismal prognosis. Despite advances in diagnosis and treatment, glioblastoma patients still have a median survival expectancy of only 14 months. This poor prognosis can be at least partly explained by the fact that glioma cells diffusely infiltrate the brain parenchyma and ...
Le Mercier, Marie, Fortin, Shannon, Mathieu, Véronique, Kiss, Robert, Lefranc, Florence   +4 more
openaire   +2 more sources

Galectin-1 and Galectin-3 in Chronic Pancreatitis [PDF]

Laboratory Investigation, 2000
Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling. To assess their potential role in chronic pancreatitis (CP), we examined their expression by Northern blot analysis, in situ hybridization, immunohistochemistry, and ...
L, Wang, H, Friess, Z, Zhu, L, Frigeri, A, Zimmermann, M, Korc, P O, Berberat, M W, Büchler   +7 more
openaire   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Biochemical Characterization of Oyster and Clam Galectins: Selective Recognition of Carbohydrate Ligands on Host Hemocytes and Perkinsus Parasites

Frontiers in Chemistry, 2020
Both vertebrates and invertebrates display active innate immune mechanisms for defense against microbial infection, including diversified repertoires of soluble and cell-associated lectins that can effect recognition and binding to potential pathogens ...
Gerardo R. Vasta, Chiguang Feng, Satoshi Tasumi, Kelsey Abernathy, Mario A. Bianchet, Iain B. H. Wilson, Katharina Paschinger, Lai-Xi Wang, Muddasar Iqbal, Anita Ghosh, Mohammed N. Amin, Brina Smith, Brina Smith, Sean Brown, Sean Brown, Aren Vista, Aren Vista   +16 more
doaj   +1 more source

Full-Length Galectin-3 Is Required for High Affinity Microbial Interactions and Antimicrobial Activity

Frontiers in Microbiology, 2021
While adaptive immunity enables the recognition of a wide range of microbial antigens, immunological tolerance limits reactively toward self to reduce autoimmunity.
Shang-Chuen Wu, Alex D. Ho, Nourine A. Kamili, Jianmei Wang, Kaleb L. Murdock, Richard D. Cummings, Connie M. Arthur, Sean R. Stowell, Sean R. Stowell   +8 more
doaj   +1 more source

Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]

, 2020
In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Martínez-Bosch, Neus, Navarro Medrano, Pilar   +1 more
openaire   +3 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity

Molecules, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
Paul V. Murphy, Sabine André, Hans-Joachim Gabius   +2 more
doaj   +1 more source

An Automated Approach to Assess Relative Galectin-Glycan Affinity Following Glycan Microarray Analysis

Frontiers in Molecular Biosciences, 2022
Numerous studies have highlighted the utility of glycan microarray analysis for the elucidation of protein-glycan interactions. However, most current glycan microarray studies analyze glycan binding protein (GBP)-glycan interactions at a single protein ...
Alex D. Ho, Shang-Chuen Wu, Nourine A. Kamili, Anna V. Blenda, Richard D. Cummings, Sean R. Stowell, Connie M. Arthur   +6 more
doaj   +1 more source