Results 31 to 40 of about 35,897 (197)
Secreted filarial nematode galectins modulate host immune cells
Frontiers in Immunology, 2022 Lymphatic filariasis (LF) is a mosquito-borne disease caused by filarial nematodes including Brugia malayi. Over 860 million people worldwide are infected or at risk of infection in 72 endemic countries.
Hannah J. Loghry +3 more
doaj +1 more source
Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR) [PDF]
International Journal of Molecular Sciences, 2016 Galectins (gal) are members of the mammalian β-galactoside-binding proteins and recognize Galβ1-4GlcNAc and Galβ1-4GalNac (Thomsen-Friedenreich antigen (TF)) sequences of several cell surface oligosaccharides. In this study, gal-1, -2, -3 and -13 were investigated systematically in the trophoblast and decidua compartment of intrauterine growth ...
Stefan Hutter +7 more
openaire +3 more sources
Utilization of Galectins by Pathogens for Infection
Frontiers in Immunology, 2020 Galectins are glycan-binding proteins which are expressed by many different cell types and secreted extracellularly. These molecules are well-known regulators of immune responses and involved in a broad range of cellular and pathophysiological functions.
Diyoly Ayona +5 more
doaj +1 more source
Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases
Cells, 2021 Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease. Gal-3’s role in the central nervous system has been less studied than in the immune system.
Luana C. Soares +7 more
doaj +1 more source
Frontiers in Oncology, 2016 Aberrant glycosylation of cell membrane proteins is a universal feature of cancer cells. One of the most common glycosylation changes in epithelial cancer is the increased occurrence of the oncofetal Thomsen-Friedenreich disaccharide Galβ1-3GalNAc (T or ...
Paulina eSindrewicz +2 more
doaj +1 more source
Hematology, 2023 Background Galectin (Gal) is considered a promising immune checkpoint molecule. More and more studies have shown that high expression levels of galectins in hematologic cancer are positively correlated with poor clinical prognosis.
Haotian Liu +4 more
doaj +1 more source
Role of Galectin in Cardiovascular Conditions including Cirrhotic Cardiomyopathy
Pharmaceuticals, 2023 Abnormal cardiac function in the setting of cirrhosis and in the absence of a primary cardiac disease is known as cirrhotic cardiomyopathy. The pathogenesis of cirrhotic cardiomyopathy is multifactorial but broadly is comprised of two pathways. The first
Hongqun Liu +2 more
doaj +1 more source
Galectin-2, Galectins-5 and -9, and Galectins-4 and -6.
Trends in Glycoscience and Glycotechnology, 1997 現在、哺乳類には10種類のガレクチンがあることが示されている。この章ではそのうち5つについて、各ガレクチンの発見の経緯と特徴について述べようと思う。ガレクチン-2はガレクチン-1と同様、14kDaのサブユニットが2量体構造をした分子で、腸上皮細胞に発現している。ガレクチン-5は15kDaの単量体ガレクチンで、赤血球に発現している。最近発見されたガレクチン-9は多くの組織で発現している36kDaのタンパク質で、2つの糖認識ドメイン (CRD) からなり、このうちC-末端側のCRDがガレクチン-5と非常に高い類似性を示す。ガレクチン-4と-6は互いにきわめて似た分子で、それぞれ36kDaと34kDaの分子量を持ち、やはりともに2つのCRDからなり、両者とも消化管の上皮細胞で発現している。
Michael A. Gitt +2 more
openaire +2 more sources
Veterinary Research, 2023 Previous studies showed that Trichinella spiralis galectin (Tsgal) facilitates larval invasion of intestinal epithelium cells (IECs). However, IEC proteins binding with Tsgal were not identified, and the mechanism by which Tsgal promotes larval invasion ...
Kai Ning Ma +9 more
doaj +1 more source
A brief history of galectin evolution
Frontiers in Immunology, 2023 Galectins are a family of carbohydrate-binding proteins found in vertebrates in great abundance and diversity in terms of both structure and ligand-binding properties as well as physiological function.
Juliane Günther +1 more
doaj +1 more source