Results 31 to 40 of about 70,530 (251)

Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives

open access: yesBiomedicines, 2021
Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt to the cell’s most appropriate growth model. However, abnormal cell metabolism is correlated with the occurrence of many diseases and is accompanied by ...
Chien-Hsiu Li   +5 more
doaj   +1 more source

Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]

open access: yes, 1998
Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Bosbach, R.   +3 more
core   +1 more source

Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis [PDF]

open access: yes, 2005
Apoptosis of cytotoxic T lymphocytes by herpes simplex virus type-1 (HSV-1) has been reported to be a relevant mechanism of viral immune evasion. Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable ...
Gonzalez, Maria Ines   +5 more
core   +1 more source

Galectins in the Tumor Microenvironment: Focus on Galectin-1 [PDF]

open access: yes, 2020
In the last decades, the focus of cancer research has moved from epithelial cells to the tumor milieu, in an effort to better understand tumor development and progression, and with the important end goal of translating this knowledge into effective therapies.
Martínez-Bosch, Neus   +1 more
openaire   +3 more sources

The Third Dimension of Reading the Sugar Code by Lectins: Design of Glycoclusters with Cyclic Scaffolds as Tools with the Aim to Define Correlations between Spatial Presentation and Activity

open access: yesMolecules, 2013
Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to generate molecular messages ...
Paul V. Murphy   +2 more
doaj   +1 more source

Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis [PDF]

open access: yes, 2006
Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models ...
Bianco, German Ariel   +6 more
core   +1 more source

Full-Length Galectin-3 Is Required for High Affinity Microbial Interactions and Antimicrobial Activity

open access: yesFrontiers in Microbiology, 2021
While adaptive immunity enables the recognition of a wide range of microbial antigens, immunological tolerance limits reactively toward self to reduce autoimmunity.
Shang-Chuen Wu   +8 more
doaj   +1 more source

Effects of canagliflozin on cardiovascular biomarkers in older adults with type 2 diabetes [PDF]

open access: yes, 2017
Background: Sodium glucose co-transporter 2 (SGLT2) inhibitors may reduce cardiovascular and heart failure risk in patients with type 2 diabetes mellitus (T2DM).
Butler, Javed   +6 more
core   +1 more source

An Automated Approach to Assess Relative Galectin-Glycan Affinity Following Glycan Microarray Analysis

open access: yesFrontiers in Molecular Biosciences, 2022
Numerous studies have highlighted the utility of glycan microarray analysis for the elucidation of protein-glycan interactions. However, most current glycan microarray studies analyze glycan binding protein (GBP)-glycan interactions at a single protein ...
Alex D. Ho   +6 more
doaj   +1 more source

Biomarkers and low risk in heart failure. Data from COACH and TRIUMPH [PDF]

open access: yes, 2015
Aim Traditionally, risk stratification in heart failure (HF) emphasizes assessment of high risk. We aimed to determine if biomarkers could identify patients with HF at low risk for death or HF rehospitalization.
Anand   +46 more
core   +1 more source

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