Results 91 to 100 of about 29,735,084 (200)
Cardiorespiratory fitness and the association with galectin-1 in middle-aged individuals.
PLoS ONEGalectin-1 plays a functional role in human metabolism and the levels are altered in obesity and type 2 diabetes (T2D). This study investigates the association of cardiorespiratory fitness (CRF) with galectin-1 and the interconnection with body fatness ...
Daniel Arvidsson +6 more
doaj +1 more source
Data_Sheet_1_The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer.docx
, 2019 Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease.
Svetlana S. Sakhnevych (6559877) +18 more
core +1 more source
, 2012 Galectin-3 is a beta-galactoside-binding lectin which is involved in modulating inflammation and apoptosis. Elevated expression of galectin-3 has been demonstrated in synovium of rheumatoid arthritis (RA).
HU, CHUNG-YI;CHANG, SHENG-KAI;WU, CHIEN-SHENG;TSAI, WEI-I;HSU, PING-NING +1 more
core +1 more source
CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity
Molecular Therapy: OncologyChronic lymphocytic leukemia (CLL) growth is dependent on both B cell receptor (BCR) signaling and signals from microenvironmental T helper (Th) cells.
John F. Imbery +11 more
doaj +1 more source
The Role of Galectin-3 in Th17 Differentiation
, 2010 第十七型輔助型T細胞 (T helper 17 cells, Th17 cells)，一個最近被大量研究的輔助型T細胞分支，在病理上被認為是導致自體免疫疾病的主要原因之一。在Th17的細胞分化以及生理作用上,之前研究中已提供許多方面深入的探討。然而在Th17細胞之負向調控機制上，則相對的較缺乏清楚的了解並且仍需要更多的研究。 在此研究中我們發現，與野生控制組相比，Galectin-3基因剔除之輔助型T細胞於體外分化時較容易且大量的分化至Th17細胞，伴隨著主要分泌之細胞激素( IL-17, IL-21 )
朱安翔, Chu, An-Hsiang
core
EV71 viruses propagated from galectin-1 silenced cells do not carry galectin-1.
, 2015 (A) Galectin-1 is silenced by lentiviral vector-based shRNA. SK-N-SH cells were infected with lentiviruses encoding a galectin-1 shRNA for 48 h. The silencing of galectin-1 in SK-N-SH cells was determined by Western blotting.
Chih-Peng Chang (193745) +12 more
core +1 more source
The Evaluation of Glyceryl C3‐Azolyl‐Thiogalactosides as Galectin‐1 and Galectin‐3 Ligands
ChemMedChemAbstractGalectins are a family of galactoside‐binding proteins involved in various pathophysiological processes, which makes them attractive targets for drug discovery. The derivatization of d‐galactose at C3 and C1 positions has been shown to increase the affinity of synthetic galectin antagonists.
Vít Prouza +5 more
openaire +3 more sources
Galectin 7 leads to a relative reduction in CD4+ T cells, mediated by PD-1
Scientific ReportsThe role of glycan-binding proteins as an activator of immune regulatory receptors has gained attention recently. We report that galectin 7 reduced CD4+ T cell percentage in both in vitro culture and mouse tumor models.
Guojin Wu +4 more
doaj +1 more source