Results 101 to 110 of about 34,736 (209)

Mediating effect of vascular calcification in galectin-3-related mortality in hemodialysis patients

Scientific Reports
Galectin-3 levels have been studied as a potential biomarker for predicting cardiovascular (CV) risk and mortality in hemodialysis (HD) patients. Recently, a close relationship between galectin-3 and vascular calcification (VC) has been reported.
Ji-Hwan Kim, Hye-Mi Noh, Hong Ji Song, Sion Lee, Sung Gyun Kim, Jwa-Kyung Kim   +5 more
doaj   +1 more source

Galectin-3 and Inflammation

Glycobiology Insights, 2016
Galectins are a family of β-galactoside-binding proteins that share a consensus sequence in the carbohydrate recognition domain (CRD). Galectin-3 is the most widely studied family member and can be found in the cellular cytoplasm and nucleus, as well as extracellularly in various tissues.
openaire   +1 more source

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

C1-Galactopyranosyl Heterocycle Structure Guides Selectivity: Triazoles Prefer Galectin‑1 and Oxazoles Prefer Galectin‑3

ACS Omega, 2019
Alexander Dahlqvist, Hakon Leffler, Ulf J. Nilsson   +2 more
doaj   +1 more source

Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice

Cell & Bioscience
Background In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor ...
Fangli Shan, Jianan Ye, Xinzhong Xu, Chao Liang, Yuanzhe Zhao, Jingwen Wang, Fangru Ouyang, Jianjian Li, Jianwei Lv, Zhonghan Wu, Fei Yao, Juehua Jing, Meige Zheng   +12 more
doaj   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Solid Subtype of Papillary Thyroid Carcinoma: A Case Series Highlighting Aggressive Features

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Hematoxylin and eosin (H&E) stained section, 40×. Tumor cells with “Orphan Annie eye” nuclei arranged in solid nests. ABSTRACT Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm. Its solid/trabecular subtype (STPTC) is rare, and its aggressiveness remains controversial.
Rafael Castellanos Bueno, Gabriela Almeyda Carreño, Diana Carolina Vergara Arenas, Laura Yibeth Esteban Badillo, Ernesto García Ayala   +4 more
wiley   +1 more source

Galectin-3 in chronic kidney disease

Clinica Chimica Acta
High serum galectin-3 has been associated with adverse outcomes among dialysis patients, although its prognostic role remains unclear among individuals with earlier-stage chronic kidney disease. The present systematic review aims to evaluate the association of serum galectin-3 with survival, cardiovascular disease and kidney disease progression among ...
Bellos, Ioannis, Marinaki, Smaragdi, Lagiou, Pagona, Benetou, Vassiliki   +3 more
openaire   +3 more sources