Results 111 to 120 of about 34,736 (209)
We performed combined proteome and transcriptome analysis of human isotype‐defined B cell subsets. IgG4‐switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4‐switched B cells.
Jana Koers +6 more
wiley +1 more source
We present a novel live‐cell imaging assay for detection of extracellular vesicle (EV)‐binding, ‐uptake, and ‐fusion in time and space. Using EVs carrying the fusogen VSV‐G, we demonstrate real‐time imaging of EV‐fusion, quantification of fusion kinetics and efficiency, and subcellular localization of fusion events.
Jasper van den Ende +5 more
wiley +1 more source
Evangelos Oikonomou +2 more
openaire +1 more source
Reduced Dietary Protein Induces Changes in the Dental Proteome
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs +2 more
wiley +1 more source
Focus on Molecules: Galectin-3 [PDF]
Pablo, Argüeso, Noorjahan, Panjwani
openaire +2 more sources
In HOMAGE, 276 plasma proteins were profiled using Olink panels. Machine learning algorithms identified galectin‐9 (GAL9), thrombospondin‐2 (THBS2), and NT‐proBNP as predictors of changes in procollagen type I C‐terminal propeptide (PICP) after spironolactone treatment.
Susana Ravassa +20 more
wiley +1 more source
Galectin-3 Inhibition in COVID-19
Kiran Reddy +2 more
openaire +4 more sources
Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song +10 more
wiley +1 more source
Abstract Allosteric modulation enables precise control of protein activity but remains difficult to harness for selective inhibitor design. Traditional high‐throughput screening for allosteric modulators is still costly and time‐consuming, underscoring the need for predictive computational approaches.
N. T. Hang Pham +8 more
wiley +1 more source

