Results 131 to 140 of about 18,236,139 (292)

Galectin-3 as a prognostic biomarker for diabetic nephropathy

, 2019
Hossam Hodeib,1 Maha M Hagras,1 Dina Abdelhai,1 Mona M Watany,1 Amal Selim,2 Mohamed A Tawfik,2 Mohamed A Elsebaey,2 Samah A Elshweikh2 1Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Internal Medicine Department, Faculty of ...
Hodeib H, Tawfik MA, Elshweikh SA, Watany MM, Elsebaey MA, Hagras MM, Selim A, Abdelhai D   +7 more
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Additional file 2: of Nuclear FAM289-Galectin-1 interaction controls FAM289-mediated tumor promotion in malignant glioma

, 2019
Figure S2. Knockdown or overexpression of Galectin-1 in U251 or U87-MG cells. A. Galectin-1 was knocked down in U251 cell lines by SiRNA1–3. Galectin-1 siRNA2 and siRNA3 significantly reduced Galectin-1expression. B.
Shi Ma (217876), Yan Ding (39795), Qiu Zhang (239441), Long Dai (7356110), Xing Guo (103312), Yu Huang (15093), Mu Wu (7356107), Hao Peng (231482), Dong Li (212687), Xu Ruan (7356116), Meng Shan (7356113), Jun Tang (32983), Jue Wang (58890)   +12 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

C1-Galactopyranosyl Heterocycle Structure Guides Selectivity: Triazoles Prefer Galectin‑1 and Oxazoles Prefer Galectin‑3

ACS Omega, 2019
Alexander Dahlqvist, Hakon Leffler, Ulf J. Nilsson   +2 more
doaj   +1 more source

sGC stimulator BAY 41‐8543 improves survival and ventricular function in a rat model of doxorubicin‐induced cardiomyopathy with nephrotic syndrome

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys, Petra Škaroupková, Soňa Kikerlová, Zdeňka Vaňourková, Martina Hüttl, Olga Lenčová, Kasin Yadunandam Anandam, Svenja Stomberg, Sönke Behrends, Barbara Szeiffová Bačová, Matúš Sykora, Lisa Dietz, Peter Sandner, Luděk Červenka, Martin Štěrba   +14 more
wiley   +1 more source

Galectin-3 functions an opsonin for efferocytosis in COPD : a process mediated by phosphatidylinositol 3-kinase

, 2011
Galectin-3 functions an opsonin for efferocytosis in COPD : a process mediated by phosphatidylinositol 3 ...
M Holmes (7753346), J Bylund (13718059), S Hodge (13655791), V Mukaro (13605415), P Reynolds (9570635), G Hodge (13287702), H Jersmann (13718062)   +6 more
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Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Galectin-3 [PDF]

, 2017
O. A. Gressner, A. M. Gressner
openaire   +2 more sources

Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced mst1 signaling

, 2019
Dilated cardiomyopathy (DCM) is a major cause of heart failure without effective therapy. Fibrogenesis plays a key role in the development of DCM, but little is known of the expression of the profibrotic factor galectin-3 (Gal-3) and its role in DCM ...
Y Su (9103940), WB Zhao (15790577), Mark Ziemann (13101363), DG Donner (10669518), Z Thomas (15790574), JR McMullen (14535023), XJ Du (11181900), A El-Osta (13358853), MN Nguyen (15790571), Q Lu (9040523), J Sadoshima (13427709), H Rafehi (13462170), H Kiriazis (10669515)   +12 more
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