Results 141 to 150 of about 18,892,704 (362)

Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z

International Journal of Molecular Sciences, 2018
Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation.
S. Sciacchitano, L. Lavra, A. Morgante, Alessandra Ulivieri, F. Magi, G. P. De Francesco, C. Bellotti, L. Salehi, A. Ricci   +8 more
semanticscholar   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins [PDF]

, 1998
The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of ...
Bovin, N. V., Burchert, M., Frank, M., Gabius, Hans-Joachim, Gilleron, M., Kaltner, Herbert, Kayser, G., Kozár, T., Lieth, Claus-Wilhelm von der, Siebert, H. C., Tajkhorshid, Emad, Vliegenthart, JFG   +11 more
core   +7 more sources

Serum Galectin-3 level and recurrence of atrial fibrillation post-ablation – Systematic review and meta-analysis

Indian Pacing and Electrophysiology Journal, 2020
Background: Serum galectin-3, a circulating biomarker of fibrosis, has been associated with atrial remodelling. Recent studies investigating serum galectin-3 and AF recurrence post-ablation have shown mixed results.
Raymond Pranata, Emir Yonas, Veresa Chintya, Alexander Edo Tondas, Sunu Budhi Raharjo   +4 more
doaj   +1 more source

Extracellular and intracellular small-molecule galectin-3 inhibitors

Scientific Reports, 2019
Galectin-3 is a carbohydrate binding protein which has important roles in cancer and immunity. Potent galectin-3 inhibitors have been synthesized, for experimental purposes and potential clinical use.
J. Stegmayr, F. Zetterberg, Michael C. Carlsson, Xiao-fei Huang, Gunjan Sharma, Barbro Kahl-Knutson, H. Schambye, U. Nilsson, S. Oredsson, H. Leffler   +9 more
semanticscholar   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Galectin-3/Gelatin Electrospun Scaffolds Modulate Collagen Synthesis in Skin Healing but Do Not Improve Wound Closure Kinetics

Bioengineering
Chronic wounds remain trapped in a pro-inflammatory state, with strategies targeted at inducing re-epithelialization and the proliferative phase of healing desirable.
Karrington A. McLeod, Madeleine Di Gregorio, Dylan Tinney, Justin Carmichael, David Zuanazzi, Walter L. Siqueira, Amin Rizkalla, Douglas W. Hamilton   +7 more
doaj   +1 more source

Galectin-3 Released by Pancreatic Ductal Adenocarcinoma Suppresses γδ T Cell Proliferation but Not Their Cytotoxicity

Frontiers in Immunology, 2020
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment with a dense desmoplastic stroma. The expression of β-galactoside-binding protein galectin-3 is regarded as an intrinsic tumor escape mechanism for ...
Daniel Gonnermann, Hans-Heinrich Oberg, Marcus Lettau, Matthias Peipp, Dirk Bauerschlag, Susanne Sebens, Dieter Kabelitz, Daniela Wesch   +7 more
doaj   +1 more source

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy : TIM-3/galectin-9 interaction and its possible role during pregnancy [PDF]

, 2014
Problem: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the
Bogár, Barbara, Farkas, Bálint, Illés, Zsolt, Meggyes, Mátyás, Mikó, Éva, Polgár, Beáta, Szereday, László   +6 more
core   +1 more source

Identifying systemic lupus erythematosus from serum proteomic profiles using machine learning and genetic risk stratification

Arthritis &Rheumatology, Accepted Article.
Objectives Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Lupus patients and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H Sawalha   +2 more
wiley   +1 more source