Results 191 to 200 of about 34,736 (209)
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Galectin 3–β-galactobiose interactions
Carbohydrate Polymers, 2013Force spectroscopy has been used to investigate the interaction between the disaccharide β-galactobiose and the pro-metastatic regulatory protein galectin-3 (Gal3). The studies revealed specific interactions characterised by an off-rate dissociation constant k(off)=0.33 s(-1) and interaction distance x=0.2 nm at zero applied force. These data suggest a
A P, Gunning, C, Pin, V J, Morris
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Immunoanalytical characteristics of galectin-3
Annales de biologie clinique, 2014This paper points out the structural and physiological data of galectin-3, and emphasizes its role in cardiac fibrosis and heart failure pathophysiology. Then we summarize the optimal conditions for sampling, assays and we discuss the interpretation of results.
Cédric, Desbène, Olivier, Gaillard
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Galectin-3 Stimulates Cell Proliferation
Experimental Cell Research, 1998Galectin-3, a beta-galactoside-binding protein, has been shown to be involved in multiple biological processes through interaction with its complementary glycoconjugates. Here we provide the first evidence of galectin-3 as a mitogen. Incubation of quiescent cultures of normal human lung fibroblast IMR-90 cells with recombinant galectin-3 (rgalectin-3 ...
H, Inohara, S, Akahani, A, Raz
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Galectin-3 Interactions with Glycosphingolipids
Journal of Molecular Biology, 2014Galectins have essential roles in pathological states including cancer, inflammation, angiogenesis and microbial infections. Endogenous receptors include members of the lacto- and neolacto-series glycosphingolipids present on mammalian cells and contain the tetrasaccharides lacto-N-tetraose (LNT) and lacto-N-neotetraose (LNnT) that form their core ...
Collins, Patrick M +3 more
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Galectin-3 and cancer (Review).
International Journal of Oncology, 2004Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported.
Califice, Stéphane +2 more
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Extracellular functions of galectin-3
Glycoconjugate Journal, 2002Galectin-3 has been suspected of modulating cell to extracellular matrix interactions in a novel fashion ever since it was first described. However, the rapid accumulation of research data in just the last 8 years alone has completely changed our perspective of this multifunctional protein.
Josiah, Ochieng +2 more
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Cardiovascular Drugs and Therapy, 2014
Myocardial galectin-3 is upregulated upon cardiac stressors such as angiotensin II and pressure overload leading to cardiac remodeling and heart failure. The expression level of galectin-3 mirrors the progression and severity of heart failure and therefore, galectin-3 is being used as a biomarker for heart failure.
de Boer, Rudolf A. +7 more
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Myocardial galectin-3 is upregulated upon cardiac stressors such as angiotensin II and pressure overload leading to cardiac remodeling and heart failure. The expression level of galectin-3 mirrors the progression and severity of heart failure and therefore, galectin-3 is being used as a biomarker for heart failure.
de Boer, Rudolf A. +7 more
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Nucleocytoplasmic Shuttling of Galectin-3
2014A large number of observations on the nuclear versus cytoplasmic distribution of galectin-3 have been reported, correlating the presence or absence of the protein in a particular compartment of the cell to various parameters such as source of the cells under study, specific cell type, culture conditions, proliferation status of the cell/culture, or ...
Eric J, Arnoys +2 more
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Endogenous galectin-3 expression levels modulate immune responses in galectin-3 transgenic mice
Molecular Immunology, 2015Galectin-3 (Gal-3), a β-galactoside-binding mammalian lectin, is involved in cancer progression and metastasis. However, there is an unmet need to identify the underlying mechanisms of cancer metastasis mediated by endogenous host galectin-3. Galectin-3 is also known to be an important regulator of immune responses.
Aparna D. Chaudhari +3 more
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