Results 191 to 200 of about 18,236,139 (292)

Galectin‐4: A Novel Mediator of Human Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 3, September 2026.
Galectin‐4 correlates with intervertebral disc degeneration, independent of age, sex, or underlying pathology. Functionally, it activates NF‐κB signaling and induces pro‐inflammatory and matrix‐degrading responses, with stronger effects in nucleus pulposus cells, identifying it as a novel molecular player in disc degeneration.
Christine Strauss, Daniel Djojic, Johannes Stadlmann, Josef Georg Grohs, Jürgen Alphonsus, Sebastian Schmidt, Sabine André, Katharina Margareta Pichler, Sara Savic‐Ivanovic, Melanie Cezanne, Mario Rothbauer, Reinhard Windhager, Stefan Toegel   +12 more
wiley   +1 more source

Association between galectin-3 and echocardiographic changes in hospitalized patients with coronavirus disease 2019: A retrospective observational study. [PDF]

J Int Med Res
Egiashvili N, Kakauridze N, Kartvelishvili D, Gvajaia N, Ratiani L.   +4 more
europepmc   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Persistent long-term subclinical myocardial changes in multisystem inflammatory syndrome in children revealed by cardiac magnetic resonance and galectin-3. [PDF]

World J Clin Pediatr
Ov SK, Pilania RK, Semwal R, Sri G, Kaur T, Subramanian P, Jindal A, Naganur S, Singh S, Singhal M.   +9 more
europepmc   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

From Oxidative Stress to Fibrotic Remodeling: Integrating Redox Biology, Galectin-3, and Imaging Phenotypes in Heart Failure. [PDF]

Antioxidants (Basel)
Ardelean S, Ardelean A, Buzzi DE, Zavragiu AC, Rus D, Zimbru EL, Morariu VI, Christodorescu RM, Sturza A, Andor M.   +9 more
europepmc   +1 more source

Patent Foramen Ovale: Epidemiology, Risk Factors, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 9, September 2026.
The clinical manifestations of PFO. Although the majority of PFOs are benign and asymptomatic, they can present with a variety of clinical manifestations, or coexisting with other diseases and aggravating their symptoms, including cerebral diseases (such as CS, epilepsy, TIA, or migraine), systemic embolism (such as embolism in renal artery, coronary ...
Linlin Meng, Xiaotong Zhang, Guangrui Sun, Honggang Dai, Xiao Meng, Cheng Zhang, Yun Zhang   +6 more
wiley   +1 more source

Prostate Cancer Biomarkers with a Focus on Galectin-3: Emerging Clinical and Therapeutic Implications. [PDF]

Curr Oncol
Narvel H, Ganiyani MA, Gulam Nabi A, Goyal A, Garje R, Srinivasan S, Ahmed H, Kilari D.   +7 more
europepmc   +1 more source

High‐Content CRISPR Screening: Methods and Applications

MedComm, Volume 7, Issue 9, September 2026.
High‐content CRISPR screening represents a paradigm shift in functional genomics, moving beyond traditional survival‐based readouts to enable multidimensional mapping of genotype–phenotype relationships. This review systematically outlines the methodological evolution of this approach, detailing advances in perturbation modalities, delivery systems ...
Yike Zhang, Yimeng Zhang, Xudong Tang, Xinyu Deng, Yitian Zhou, Yanfeng Wu, Jianhua Luo   +6 more
wiley   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source