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Taloside Inhibitors of Galectin‐1 and Galectin‐3
Chemical Biology & Drug Design, 2012Galectin‐1 and galectin‐3 have roles in cancer and inflammation. Galectin‐1 has recently emerged as a significant protein produced by tumour cells to promote tumour development, angiogenesis and metastasis and consequently represents an important target to inhibit.
Collins, Patrick M +4 more
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European Journal of Heart Failure, 2009
Galectins are a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation, immunity, and cancer. Recently, a role for galectin-3 in the pathophysiology of heart failure (HF) has been suggested. Numerous studies have demonstrated the up-regulation of galectin-3 in hypertrophied hearts, its stimulatory ...
de Boer, Rudolf A. +4 more
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Galectins are a family of soluble beta-galactoside-binding lectins that play many important regulatory roles in inflammation, immunity, and cancer. Recently, a role for galectin-3 in the pathophysiology of heart failure (HF) has been suggested. Numerous studies have demonstrated the up-regulation of galectin-3 in hypertrophied hearts, its stimulatory ...
de Boer, Rudolf A. +4 more
openaire +1 more source
Therapeutic Potential of Galectin-1 and Galectin-3 in Autoimmune Diseases
Current Pharmaceutical Design, 2022:Galectins are a highly conserved protein family that binds to β-galactosides. Different members of this family play a variety of biological functions in physiological and pathological processes such as angiogenesis, regulation of immune cell activity, and cell adhesion.
Yi-Sheng, He +10 more
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Galectin-3 Interactions with Glycosphingolipids
Journal of Molecular Biology, 2014Galectins have essential roles in pathological states including cancer, inflammation, angiogenesis and microbial infections. Endogenous receptors include members of the lacto- and neolacto-series glycosphingolipids present on mammalian cells and contain the tetrasaccharides lacto-N-tetraose (LNT) and lacto-N-neotetraose (LNnT) that form their core ...
Collins, Patrick M +3 more
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Galectin-3 and cancer (Review).
International Journal of Oncology, 2004Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported.
Califice, Stéphane +2 more
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Laboratoriumsmedizin-Journal of laboratory medicine, 2013
Galectin-3 is a carbohydrate-binding protein involved in inflammatory and fibrotic processes in various tissues. In the heart, galectin-3 activation has been associated with progression of cardiac fibrosis leading to cardiac remodeling and heart failure development.
de Boer, Rudolf A. +1 more
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Galectin-3 is a carbohydrate-binding protein involved in inflammatory and fibrotic processes in various tissues. In the heart, galectin-3 activation has been associated with progression of cardiac fibrosis leading to cardiac remodeling and heart failure development.
de Boer, Rudolf A. +1 more
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Extracellular functions of galectin-3
Glycoconjugate Journal, 2002Galectin-3 has been suspected of modulating cell to extracellular matrix interactions in a novel fashion ever since it was first described. However, the rapid accumulation of research data in just the last 8 years alone has completely changed our perspective of this multifunctional protein.
Josiah, Ochieng +2 more
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Immunoanalytical characteristics of galectin-3
Annales de biologie clinique, 2014This paper points out the structural and physiological data of galectin-3, and emphasizes its role in cardiac fibrosis and heart failure pathophysiology. Then we summarize the optimal conditions for sampling, assays and we discuss the interpretation of results.
Cédric, Desbène, Olivier, Gaillard
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Nucleocytoplasmic Shuttling of Galectin-3
2014A large number of observations on the nuclear versus cytoplasmic distribution of galectin-3 have been reported, correlating the presence or absence of the protein in a particular compartment of the cell to various parameters such as source of the cells under study, specific cell type, culture conditions, proliferation status of the cell/culture, or ...
Eric J, Arnoys +2 more
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Evaluation of galectin-1 and galectin-3 as prospective biomarkers in keratoconus
British Journal of Ophthalmology, 2018AimsTo evaluate the expression of β-galactoside-binding proteins galectin (Gal)-1 and Gal-3 in patients with keratoconus (KC) and postcorneal collagen cross-linking (CXL) treatment in vitro.MethodsTear fluid, cornea samples and conjunctival impression cytology specimens from control and KC patients were used to evaluate Gal-1 and Gal-3 expressions ...
Frans Eberth Costa Andrade +7 more
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