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Galectin-3 and metastasis

Glycoconjugate Journal, 2002
Galectin-3, a 31 kDa member of the beta-galactoside-binding proteins, is an intracellular and extracellular lectin which interacts with intracellular glycoproteins, cell surface molecules and extracellular matrix proteins. Galectin-3 is expressed widely in epithelial and immune cells and its expression is correlated with cancer aggressiveness and ...
Yukinori Takenaka   +2 more
exaly   +3 more sources

The regulation of inflammation by galectin‐3

Immunological Reviews, 2009
Summary:  Galectin‐3 is a β‐galactoside‐binding animal lectin of appro‐ ximately 30 kDa and is evolutionarily highly conserved. Galectin‐3 is promiscuous, its localization within the tissue micro‐environment may be extracellular, cytoplasmic, or nuclear, and it has a concentration‐dependent ability to be monomeric or form oligomers.
Neil Henderson
exaly   +4 more sources

Galectin-3 in cancer

Clinica Chimica Acta, 2014
Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-
Lin, Song   +5 more
openaire   +2 more sources

The expression profiles of the galectin gene family in primary and metastatic papillary thyroid carcinoma with particular emphasis on galectin-1 and galectin-3 expression [PDF]

open access: yesExperimental and Molecular Pathology, 2014
Introduction Galectin family members have been demonstrated to be abnormally expressed in cancer at the protein and mRNA level. This study investigated the levels of galectin proteins and mRNA expression in a large cohort of patients with papillary ...
Vinod Gopalan   +2 more
exaly   +2 more sources

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