Results 111 to 120 of about 9,887 (270)

Galectins: Important Regulators in Normal and Pathologic Pregnancies

, 2022
Galectins (Gal) are characterized by their affinity for galactoside structures on glycoconjugates. This relationship is mediated by carbohydrate recognition domains, which are multifunctional regulators of basic cellular biological processes with high ...
Shao, Jun, Zi-Meng Zheng, Chen, Min, Li, Ming-Qing, Zheng, Zi-Meng, Min Chen, Zhi Lin, Lin, Zhi, Jia-Lu Shi, Ming-Qing Li, Jun Shao, Shi, Jia-Lu   +11 more
core   +1 more source

Platelets and galectins.

Annals of translational medicine, 2014
Fil: Schattner, Mirta Ana.
openaire   +2 more sources

The role of galectins in cancer cell invasiveness

, 2018
Galectins are family of β-galactosidase binding proteins that serve many functions in all kind of mammalian cells. In the past years galectins, namely galectin-1 and galectin-3, have been revealed to play a major role in various cancer processes ...
Remišová, Michaela
core  

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

When Explant Surprises: Management and Outcomes of Hepatocellular Carcinoma Beyond Milan Criteria Discovered Post‐Transplant‐ A Narrative Review of Literature

Journal of Surgical Oncology, EarlyView.
ABSTRACT Liver transplantation (LT) is the definitive treatment for early hepatocellular carcinoma (HCC), based on established criteria. Pre‐transplant imaging occasionally underestimates the tumor burden or biological aggressiveness, leading to explant pathology that exceeds the projection criteria, such as Milan.
Serkan Sucu, Brian Longbottom, Hassan Aziz   +2 more
wiley   +1 more source

Evolutionary analysis of galectins and identification of potential galectin-1 inhibitors: A computational approach

Bangladesh Journal of Pharmacology, 2014
Galectins are a family of structurally related carbohydrate-binding proteins and some galectins play a major role in initiation, progression and dissemination of different types of tumors.
Vipperla Bhavaniprasad, Krishnan Anbarasu, Sivaraman Jayanthi   +2 more
doaj   +2 more sources

FOXC1: A Key Transcription Factor of VSMC‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Ling‐Lin Qian, Xue‐Ling Li, Li‐Hong Wang, Wei Yang, Yu Jiang   +4 more
wiley   +1 more source

Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis

Biological Research
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes.
Elisa Perez-Moreno, Claudia Oyanadel, Adely de la Peña, Ronny Hernández, Francisca Pérez-Molina, Claudia Metz, Alfonso González, Andrea Soza   +7 more
doaj   +1 more source

Mucolipin TRP Cation Channel 1 Depletion Promotes Gastric Cancer Cell Ferroptosis Through the AKT Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mucolipin TRP cation channel 1 (MCOLN1), also called TRPML1, drives the progression of various cancers and inhibits ferroptosis in a number of diseases. This study aimed to investigate whether MCOLN1 depletion regulates ferroptosis in gastric cancer and its molecular regulatory crosstalk with the AKT pathway.
Jing Wang, Jun‐Chen Ge, Jian Ma, Xin Wang, Wen Jia, Li Zhu   +5 more
wiley   +1 more source

Examining the role of endothelial derived galectins in vascular inflammation [PDF]

This thesis explores how galectins, sugar-binding proteins, influence leukocyte trafficking during inflammation. Galectins (Gal) are known to be involved in inflammation, but specific endothelial-galectin interactions remain unclear.
Lightfoot, Abbey
core   +4 more sources