Results 131 to 140 of about 9,659 (276)

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

Phytotherapy Research, EarlyView.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo, Paola Lasso, Claudia Urueña, Susana Fiorentino   +3 more
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Galectins, (re)myelination and multiple sclerosis pathology [PDF]

, 2012
Multiple sclerosis (MS) is a chronic, progressive, degenerative disorder of the central nervous system, characterized by inflammation-mediated demyelination, followed by failure of remyelination and axonal loss.
Stancic, Mirjana,, Stancic, Mirjana
core   +2 more sources

The Evolution of Galectins in Bivalves

, 2022
Bivalves are currently under threat of disease; these species aren't able to adapt and respond to diseases in the same way that vertebrates do because they don't have an adaptive immune system.
Willow Dreger (14770189)
core  

Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures

Allergy, EarlyView.
This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally, Takeshi Yoshida, Shan Gao, Xueya Cai, Donald Y. M. Leung, Lisa A. Beck, Anna De Benedetto   +6 more
wiley   +1 more source

Galectins 1, 3 and 9 in patients with systemic lupus erythematosus: is there an association with disease activity or clinical manifestations?

Современная ревматология
Objective. To compare serum concentrations of galectins 1, 3 and 9 in women with systemic lupus erythematosus (SLE) and healthy donors; to assess the relationship of these biomarkers with disease activity and specific clinical manifestations.Material and
L. V. Kondrateva, T. A. Panafidina, Yu. N. Gorbunova, T. V. Popkova, M. E. Diatroptov, A. S. Avdeeva   +5 more
doaj   +1 more source

Increased expression of distinct galectins in multiple sclerosis lesions

, 2011
Aims: Multiple sclerosis (MS) is a chronic progressive degenerative disorder of the central nervous system, characterized by inflammation, demyelination, ultimate failure of remyelination and axonal loss.
Thijssen, V.L., Thijssen, V. L., W. Baron, D. Hoekstra, P. van der Valk, van Horssen, J., Valk, P. van der, Baron, W.; id_orcid, Horssen, J. van, Baron, W., J. van Horssen, Stantic, M., Gabius, H.J., Hoekstra, D., M. Stancic, van der Valk, P., Stancic, M., V. L. Thijssen, H.-J. Gabius, Gabius, H. -J.   +19 more
core   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

Analysis of cancer-associated glycosyltransferases reveals novel targets of non-small cell lung cancer pathogenesis

Frontiers in Oncology
BackgroundAberrant glycosylation is associated with cancer progression and patient survival, of which the driving genes could act as biomarkers.
Chang Liu, Chang Liu, Chang Liu, Chang Liu, Thomas van Ee, Thomas van Ee, Thomas van Ee, Jurriaan Janssen, Jurriaan Janssen, Ernesto Rodríguez, Ernesto Rodríguez, Ernesto Rodríguez, Yongsoo Kim, Yongsoo Kim, Teodora Radonic, Victor W. van Beusechem, Victor W. van Beusechem, Victor W. van Beusechem, Marieke F. Fransen, Marieke F. Fransen, Marieke F. Fransen, Idris Bahce, Yvette van Kooyk   +22 more
doaj   +1 more source