Results 131 to 140 of about 9,887 (270)
, 2014 Galectins are a family of galactoside-specific lectins that are involved in a myriad of metabolic and disease processes. Due to roles in cancer, inflammatory and heart diseases, galectins are attractive targets for drug development.
Hugo, Matthew W +2 more
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Small, EarlyView.Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan +14 more
wiley +1 more source
The Role of Galectins in Asthma Pathophysiology: A Comprehensive Review
Current Issues in Molecular BiologyGalectins are a group of β-galactoside-binding proteins with several roles in immune response, cellular adhesion, and inflammation development. Current evidence suggest that these proteins could play a crucial role in many respiratory diseases such as ...
Andrea Portacci +6 more
doaj +1 more source
Integrative Zoology, EarlyView.High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang +6 more
wiley +1 more source
Galectins in tumor angiogenesis.
Annals of translational medicine, 2014 The expansion of solid tumors depends on the continuous ingrowth of new blood vessels out of pre-existing capillaries. Consequently, tumor neovascularization or tumor angiogenesis is considered a hallmark of cancer and an attractive target for cancer therapy. Tumor angiogenesis is mainly carried out by endothelial cells (EC), i.e., the cells lining the
Griffioen, A.W., Thijssen, V.L.J.L.
openaire +4 more sources
Serum‐Proteomic Profiling Reveals Distinct Atopic Dermatitis Severity‐Linked Signatures
Allergy, EarlyView.This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial enriched severity footprint linked to LDH‐associated tissue injury and Th2/Th22 inflammation.
Jag S. Lally +6 more
wiley +1 more source
The intricate relationship between cytokines and galectins in immune modulation
The human immune system is a complex defense mechanism that protects the body against external and internal threats. Disruption of an effective immune response can lead to detrimental effects, such as autoimmune diseases or cancer.
Koenen, Rory R.; id_orcid +2 more
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Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma
Allergy, EarlyView.This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez +14 more
wiley +1 more source
, 2018 Galectins are members of the animal lectin family that bind to the β-galactoside-containing carbohydrate moieties of glycoconjugates. They seem to have an important role in the pathophysiology of several diseases, including arthritis. Osteoarthritis (OA)
Milena Fini +7 more
core +1 more source
Single‐Cell Omics Profiling Reveals Enhanced Heterogeneity of Cord Blood Basophils at Birth
Allergy, EarlyView.Cord basophils exhibit greater heterogeneity and diverse functional states relative to maternal basophils. Maternal and cord blood basophils have different transcriptomics and functional profiles. Cord basophil exhibits earlier pseudotime than maternal basophil, potentially indicating a more naïve state.
Jing Hui Low +15 more
wiley +1 more source