Results 151 to 160 of about 13,626 (296)

Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation

Glia, Volume 74, Issue 5, May 2026.
– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemel   +4 more
wiley   +1 more source

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Unusual Cytology Features of A DICER1‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Cytopathology, Volume 37, Issue 3, Page 300-303, May 2026.
This article describes the unusual cytology features of a DICER1‐mutated thyroid nodule. Fine needle aspiration revealed predominantly cell debris/degenerated cells and rare viable follicular cells with mild cytologic atypia. Surgical resection revealed a nodule with nearly complete infarction, which is one specific feature of DICER1‐mutated thyroid ...
Wenli Dai, Eduardo V. Zambrano, Sabri Yilmaz, Qian Wang   +3 more
wiley   +1 more source

Clinical Outcomes and Non‐Invasive Testing in Metabolic Dysfunction‐Associated Steatohepatitis With Cirrhosis: A Systematic Review

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH) with cirrhosis lacks definitive treatments and poses an increasing healthcare burden globally. We undertook a systematic literature review (SLR) to better understand the disease burden in cirrhosis due to MASH.
Hannes Hagström, Chris Hellmund, Jeffrey V. Lazarus, Riku Ota, Mary E. Rinella, Giada Sebastiani, Fotis Tefos, Zobair M. Younossi, Mazen Noureddin   +8 more
wiley   +1 more source

Abnormal Galectin Signaling in the Pathomechanisms of Placental Dysfunction in Gestational Diabetes Mellitus. [PDF]

Int J Mol Sci
Szukiewicz D.
europepmc   +1 more source

Baseline Alkaline Phosphatase Impacts Response Rates in Primary Biliary Cholangitis: Exploring Response to Elafibranor in ELATIVE

Liver International, Volume 46, Issue 5, May 2026.
ABSTRACT Background & Aims Baseline alkaline phosphatase (ALP) levels can influence the likelihood of achieving dichotomous biochemical response criteria in primary biliary cholangitis (PBC). This concept was explored using Week 52 data from the phase III ELATIVE trial (NCT04526665), which assessed elafibranor, a peroxisome proliferator‐activated ...
Cynthia Levy, Christopher L. Bowlus, Eric Lawitz, Nuno Antunes, Benjamin Miller, Jianfen Shu, Claudia O. Zein, Kris V. Kowdley   +7 more
wiley   +1 more source

Galectin-8 binds HIV envelope glycoproteins with high affinity and promotes viral infectivity. [PDF]

Front Cell Infect Microbiol
Sheik-Khalil E, Kahl-Knutson B, Johansson E, Karlson S, Nilsson UJ, Leffler H, Jansson M.   +6 more
europepmc   +1 more source

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal–Fetal Tolerance

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao, Li Zou, Yao Yao, Changling Liu   +3 more
wiley   +1 more source

Disorder of the immune and inflammatory response involving galectin-1, -3 and -7 in women with invasive breast cancer - potential importance in diagnosis and monitoring the course of the disease. [PDF]

Front Oncol
Królewska-Daszczyńska P, Kabut J, Kruszniewska-Rajs C, Gola JM, Paul-Samojedny M, Mielczarek-Palacz A.   +5 more
europepmc   +1 more source